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Results for “HIF-2α”

18 trials

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Showing 18 of 18 results

Large-scale testing (Phase 3)Active Not RecruitingNCT05239728
What this trial is testing

Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 1,800
Early research (Phase 1)Active Not RecruitingNCT04846920
What this trial is testing

Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carcinoma (MK-6482-018)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 52
Large-scale testing (Phase 3)Active Not RecruitingNCT04195750
What this trial is testing

Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 755
Not applicableActive Not RecruitingNCT07332923
What this trial is testing

Predicting HIF-2α Levels in Clear Cell Kidney Cancer Using Machine Learning

Who this might be right for
Renal Clear Cell CarcinomaHIF-2αRadiomics+1 more
First Affiliated Hospital of Fujian Medical University 500
Testing effectiveness (Phase 2)Active Not RecruitingNCT05468697
What this trial is testing

Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

Who this might be right for
Renal Cell Carcinoma
Merck Sharp & Dohme LLC 60
Testing effectiveness (Phase 2)Looking for participantsNCT07167329
What this trial is testing

Real-World Effectiveness and Pharmacogenetics of Belzutifan in VHL Syndrome: The BELIEVE-VHL Trial

Who this might be right for
Von Hippel LindauVon Hippel Lindau DiseaseVon Hippel Lindau-Deficient Clear Cell Renal Cell Carcinoma+5 more
José Claudio Casali da Rocha 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT03634540
What this trial is testing

A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)

Who this might be right for
Renal Cell Carcinoma (RCC)Clear Cell Renal Cell Carcinoma (ccRCC)Kidney Cancer+6 more
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 118
Early research (Phase 1)Active Not RecruitingNCT02293980
What this trial is testing

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)

Who this might be right for
ccRCCRCCKidney Cancer+2 more
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 110
Testing effectiveness (Phase 2)Looking for participantsNCT04924075
What this trial is testing

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Who this might be right for
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau Disease+2 more
Merck Sharp & Dohme LLC
Testing effectiveness (Phase 2)Active Not RecruitingNCT04489771
What this trial is testing

Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

Who this might be right for
Carcinoma, Renal Cell
Merck Sharp & Dohme LLC 154
Early research (Phase 1)Active Not RecruitingNCT02974738
What this trial is testing

A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)

Who this might be right for
Advanced Solid TumorsSolid TumorSolid Carcinoma+13 more
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 120
Early research (Phase 1)Active Not RecruitingNCT04895748
What this trial is testing

DFF332 as a Single Agent and in Combination With Everolimus & Immuno-Oncology Agents in Advanced/Relapsed Renal Cancer & Other Malignancies

Who this might be right for
Carcinoma, Renal Cell
Novartis Pharmaceuticals 40
Early research (Phase 1)Active Not RecruitingNCT05030506
What this trial is testing

Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)

Who this might be right for
Renal Cell Carcinoma
Merck Sharp & Dohme LLC 45
Testing effectiveness (Phase 2)Looking for participantsNCT07049926
What this trial is testing

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

Who this might be right for
Renal Cell Carcinoma
Merck Sharp & Dohme LLC 140
Large-scale testing (Phase 3)Active Not RecruitingNCT07000149
What this trial is testing

Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCC

Who this might be right for
Advanced Clear Cell Renal Cell Carcinoma
AstraZeneca 1,116
Testing effectiveness (Phase 2)Ended earlyNCT05119335
What this trial is testing

NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

Who this might be right for
ccRCCClear Cell Renal Cell CarcinomaKidney Cancer+14 more
NiKang Therapeutics, Inc. 120
Early research (Phase 1)Study completedNCT05117554
What this trial is testing

Study to Investigate the Safety, Tolerability, and Pharmacokinetic Profile With Oral AB521 in Healthy Volunteers

Who this might be right for
Healthy Participants
Arcus Biosciences, Inc. 70
Early research (Phase 1)Study completedNCT06919991
What this trial is testing

Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)

Who this might be right for
Healthy Participants
Arcus Biosciences, Inc. 14
322