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Results for “HRR Deficiency”

89 trials

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Showing 20 of 89 results

Testing effectiveness (Phase 2)UnknownNCT05461690
What this trial is testing

Phase II Study of Niraparib in Metastatic TNBC Patients With Homologous Recombination Deficiency

Who this might be right for
Homologous Recombination DeficiencyTriple Negative Breast Cancer
Zhejiang Cancer Hospital 50
Testing effectiveness (Phase 2)Ended earlyNCT05689021
What this trial is testing

CJNJ-67652000 and Prednisone for Treatment of Metastatic Castration-Resistant Prostate Cancer and SPOP Gene Mutations

Who this might be right for
Castration-Resistant Prostate CarcinomaMetastatic Prostate AdenocarcinomaStage IVB Prostate Cancer AJCC v8
Mayo Clinic 8
Large-scale testing (Phase 3)Looking for participantsNCT06095141
What this trial is testing

Cisplatin to Patients With Pancreatic Cancer and Homologous Recombination Deficiency

Who this might be right for
Pancreatic AdenocarcinomaHomologous Recombination Deficiency
Fudan University 30
Testing effectiveness (Phase 2)Looking for participantsNCT07033819
What this trial is testing

Neoadjuvant Treatment of Ovarian Cancer With Fuzuloparib in Combination With Apatinib

Who this might be right for
Ovarian Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 48
Testing effectiveness (Phase 2)Looking for participantsNCT04503265
What this trial is testing

A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

Who this might be right for
Advanced Malignant NeoplasmBreast CancerOvarian Cancer+3 more
AtlasMedx, Incorporated 122
Testing effectiveness (Phase 2)Study completedNCT00753545
What this trial is testing

Assessment of Efficacy of AZD2281 in Platinum Sensitive Relapsed Serous Ovarian Cancer

Who this might be right for
Ovarian Cancer
AstraZeneca 265
Testing effectiveness (Phase 2)Ended earlyNCT03367689
What this trial is testing

A Two-stage Simon Design Phase II Study for Non-BRCA MBC Patients With HRD Treated With Olaparib Single Agent

Who this might be right for
Breast Cancer
MedSIR 7
Not applicableUnknownNCT04190667
What this trial is testing

Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

Who this might be right for
Epithelial Ovarian CancerChineseHomologous Recombination Deficiency+3 more
Lei Li 1,300
Testing effectiveness (Phase 2)UnknownNCT04499118
What this trial is testing

AT Versus TP as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer

Who this might be right for
HER2-negative Breast Cancer
Sichuan Provincial People's Hospital 100
Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Early research (Phase 1)Ended earlyNCT03209401
What this trial is testing

Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

Who this might be right for
Solid Tumor, AdultHomologous Recombination Deficiency
Georgetown University 23
Not applicableLooking for participantsNCT05965557
What this trial is testing

Exploration of Predictive Markers of Neoadjuvant Immunotherapy in Non-Small Cell Lung Cancer

Who this might be right for
Lung Cancer
Geneplus-Beijing Co. Ltd. 100
Early research (Phase 1)Not Yet RecruitingNCT07088588
What this trial is testing

Study of SYN608 for the Treatment of Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced Solid CancerMetastatic Solid TumorOvarian Cancer+3 more
Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd 105
Not applicableUnknownNCT05255861
What this trial is testing

An Exploratory Study of HRD Score in Chinese Ovarian Cancer Patients Benefiting From PARP Inhibitor Targeted Therapy

Who this might be right for
Ovarian Cancer
Xin Wu 300
Testing effectiveness (Phase 2)Ended earlyNCT03442556
What this trial is testing

Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency

Who this might be right for
ATM Gene MutationBRCA1 Gene MutationBRCA2 Gene Mutation+7 more
University of Washington 18
Testing effectiveness (Phase 2)Looking for participantsNCT04515836
What this trial is testing

Olaparib in Patients With HRD Malignant Mesothelioma

Who this might be right for
MesotheliomaHomologous Recombination Deficiency
University of Chicago 56
Large-scale testing (Phase 3)Study completedNCT01968213
What this trial is testing

Phase 3 Study of Rucaparib as Switch Maintenance After Platinum in Relapsed High Grade Serous or Endometrioid Ovarian Cancer (ARIEL3)

Who this might be right for
Ovarian CancerFallopian Tube CancerPeritoneal Cancer
pharmaand GmbH 564
Not applicableActive Not RecruitingNCT07303218
What this trial is testing

The HER Project: HRD in EGFR-mutated NSCLC

Who this might be right for
EGFRNon Small Cell Lung CancerHomologous Recombination Deficiency+1 more
IRCCS San Raffaele 100
Testing effectiveness (Phase 2)UnknownNCT03337087
What this trial is testing

Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

Who this might be right for
Metastatic Biliary Tract CarcinomaMetastatic Colorectal CarcinomaMetastatic Gastroesophageal Junction Adenocarcinoma+6 more
Academic and Community Cancer Research United 18
Testing effectiveness (Phase 2)Looking for participantsNCT07446855
What this trial is testing

Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours

Who this might be right for
Solid Tumours
AstraZeneca 180
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