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Results for “Hereditary Emphysema (Alpha 1-antitrypsin Deficiency)”

137 trials

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Showing 20 of 137 results

Early research (Phase 1)Study completedNCT06186492
What this trial is testing

Research Study to Evaluate Safety, Tolerability, and Pharmacokinetics of WVE-006 in Healthy Participants With Wild-type AAT Expression (RestorAATion-1)

Who this might be right for
Alpha-1 Antitrypsin Deficiency (AATD)
Wave Life Sciences USA, Inc. 47
Large-scale testing (Phase 3)Study completedNCT00301366
What this trial is testing

The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Grifols Therapeutics LLC 38
Not applicableStudy completedNCT02922751
What this trial is testing

FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)

Who this might be right for
Biliary AtresiaAlagille SyndromeAlpha1 Anti-Trypsin Deficiency+3 more
Arbor Research Collaborative for Health 552
Testing effectiveness (Phase 2)Study completedNCT03679598
What this trial is testing

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency

Who this might be right for
Alpha-1 Antitrypsin Deficiency (AATD)Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I MutationsEmphysema or COPD
University of Alabama at Birmingham 63
Not applicableEnded earlyNCT01357460
What this trial is testing

Endoscopic Lung Volume Reduction in Patients With Advanced Emphysema Due to alpha1 Antitrypsin Deficiency

Who this might be right for
Hereditary Emphysema (Alpha 1-antitrypsin Deficiency)
Heidelberg University 18
Early research (Phase 1)Study completedNCT01319331
What this trial is testing

The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes

Who this might be right for
DiabetesType 1 Diabetes
University of Colorado, Denver 12
Large-scale testing (Phase 3)Looking for participantsNCT07555483
What this trial is testing

A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)

Who this might be right for
Alpha 1 Antitrypsin Deficiency
Grifols Therapeutics LLC 40
Not applicableNot Yet RecruitingNCT06029543
What this trial is testing

Permian Health Women's Lung Health Study

Who this might be right for
COPDLung Function DecreasedAlpha 1-Antitrypsin
Permian Health Lung Institute 350
Testing effectiveness (Phase 2)Study completedNCT02947087
What this trial is testing

Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis

Who this might be right for
Chronic Pancreatitis
Medical University of South Carolina 48
Not applicableUnknownNCT05622838
What this trial is testing

Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women

Who this might be right for
alpha1 Anti-trypsinPre-EclampsiaIntrauterine Growth Restriction
Assiut University 160
Not applicableStudy completedNCT01615484
What this trial is testing

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

Who this might be right for
EmphysemaChronic Obstructive Pulmonary Disease (COPD)Cystic Fibrosis+5 more
University of North Carolina, Chapel Hill 24
Not applicableUnknownNCT03455686
What this trial is testing

Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

Who this might be right for
AsthmaChronic Obstructive Pulmonary DiseaseBronchiectasis+5 more
McMaster University 60
Not applicableEnrolling By InvitationNCT06892236
What this trial is testing

Preparation of IPSC for Cell Gene Editing for the Treatment of AATD

Who this might be right for
Alpha1-antitrypsin Deficiency
Fondazione IRCCS Policlinico San Matteo di Pavia 3
Not applicableEnded earlyNCT02502201
What this trial is testing

Environment Effect on Six-Minute Walk Test Performance

Who this might be right for
Chronic Obstructive Pulmonary DiseaseAlpha-1 Antitrypsin Deficiency
University of Florida 27
Testing effectiveness (Phase 2)Looking for participantsNCT07227207
What this trial is testing

TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)

Who this might be right for
Alpha-1 Antitrypsin Deficiency (AATD)
Tessera Therapeutics, Inc. 72
Testing effectiveness (Phase 2)UnknownNCT02191839
What this trial is testing

Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery

Who this might be right for
Post Cardiac Surgery Systemic Inflammatory Response
Soroka University Medical Center 20
Not applicableNo Longer AvailableNCT03172455
What this trial is testing

Early Access Program Using Alpha 1 Antitrypsin Infusion for Patients With Steroid Refractory Acute GvHD After Hematopoietic Stem Cell Transplantation (HSCT)

Who this might be right for
Acute-graft-versus-host DiseaseSteroid Refractory Acute Graft Versus Host DiseaseGraft-versus-host-disease+5 more
Impatients N.V. trading as myTomorrows
Not applicableStudy completedNCT00001462
What this trial is testing

Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals

Who this might be right for
EmphysemaLung Diseases, ObstructiveAlpha 1-Antitrypsin Deficiency
National Heart, Lung, and Blood Institute (NHLBI) 60
Testing effectiveness (Phase 2)WithdrawnNCT03385395
What this trial is testing

Study Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin Deficiency

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Octapharma
Testing effectiveness (Phase 2)Study completedNCT03008915
What this trial is testing

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency

Who this might be right for
Alpha-1 Antitrypsin DeficiencyEmphysemaChronic Obstructive Pulmonary Disease
Columbia University 15
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