Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Hereditary Spastic Paraparesis”

48 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 48 results

Not applicableEnded earlyNCT02859428
What this trial is testing

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Who this might be right for
Hereditary Spastic Paraplegia
National Institute of Neurological Disorders and Stroke (NINDS) 51
Not applicableLooking for participantsNCT06572046
What this trial is testing

STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies

Who this might be right for
Hereditary Spastic Paraplegia
IRCCS Fondazione Stella Maris 500
Not applicableStudy completedNCT05613114
What this trial is testing

Effect of Dalfampridine in Patients With Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
European University of Lefke 8
Not applicableActive Not RecruitingNCT06573866
What this trial is testing

Enhancement of Quality of Work And Life

Who this might be right for
Parkinson DiseaseHereditary Spastic ParaparesisCerebellar Ataxia+2 more
Radboud University Medical Center 124
Not applicableStudy completedNCT04912609
What this trial is testing

Trehalose Administration in Subjects With Spastic Paraplegia 11 (3AL-SPG11)

Who this might be right for
Hereditary Spastic ParaplegiaSpastic Paraplegia Type 11
IRCCS Fondazione Stella Maris 13
Not applicableLooking for participantsNCT06844734
What this trial is testing

A Prospective Cohort Study of ITB Treatment for HSP

Who this might be right for
Hereditary Spastic Paraplegia
Shanghai 6th People's Hospital 50
Not applicableStudy completedNCT04180098
What this trial is testing

Improving Gait Adaptability in Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic ParaplegiaStrumpell Disease
Radboud University Medical Center 36
Not applicableStudy completedNCT00023075
What this trial is testing

Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis

Who this might be right for
Primary Lateral SclerosisHereditary Spastic ParaplegiaAmyotrophic Lateral Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS) 55
Not applicableActive Not RecruitingNCT02327845
What this trial is testing

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Who this might be right for
Amyotrophic Lateral SclerosisFrontotemporal DementiaPrimary Lateral Sclerosis+3 more
University of Miami 708
Not applicableLooking for participantsNCT06742697
What this trial is testing

Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
IRCCS Eugenio Medea 20
Not applicableLooking for participantsNCT07798674
What this trial is testing

TreatHSP Platform: Adaptive Natural History Platform for Ataxias, HSPs, and Spastic Ataxias

Who this might be right for
Hereditary Spastic ParaplegiaSpastic Ataxia
Heidelberg University 4,000
Not applicableStudy completedNCT03204773
What this trial is testing

Studying Non-motor Symptoms in HSP

Who this might be right for
SPG4
University Hospital Tuebingen 236
Not applicableLooking for participantsNCT05354622
What this trial is testing

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Who this might be right for
Hereditary Spastic ParaplegiaNeurodegenerative DiseasesPediatric Disorder+3 more
Boston Children's Hospital 200
Not applicableLooking for participantsNCT07090057
What this trial is testing

The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children

Who this might be right for
Idiopathic Toe WalkingCerebral PalsyHereditary Spastic Paraparesis+5 more
University of Alberta 42
Not applicableStudy completedNCT05767268
What this trial is testing

Assessment of the Psychophysical State During Rehabilitation Treatment With Lokomat

Who this might be right for
Cerebral PalsyAcquired Brain InjuryHereditary Spastic Paraplegia
IRCCS Eugenio Medea 48
Not applicableStudy completedNCT07799233
What this trial is testing

Dental-Oral and Craniofacial Characteristics of Hereditary Spastic Paraplegia: A Preliminary Study

Who this might be right for
Hereditary Spastic Paraplegia
University of Barcelona 50
Early research (Phase 1)Study completedNCT06117020
What this trial is testing

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Who this might be right for
Muscle SpasticityHypertonia, MuscleCerebral Palsy+5 more
Motric Bio 89
Not applicableLooking for participantsNCT05848271
What this trial is testing

Natural History Study of Patients with HPDL Mutations

Who this might be right for
Mitochondrial EncephalomyopathiesHereditary Spastic ParaplegiaSpastic Paraplegia+4 more
University of California, San Diego 50
Large-scale testing (Phase 3)Study completedNCT02604186
What this trial is testing

Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
University of Campinas, Brazil 55
Not applicableLooking for participantsNCT07136844
What this trial is testing

Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

Who this might be right for
Neuromuscular DiseasesObesity (Disorder)Myotonic Dystrophy 1+9 more
Centre Hospitalier Universitaire de Liege 300
Next Page