Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Hereditary Spastic Paraplegia”

52 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 52 results

Not applicableStudy completedNCT04256681
What this trial is testing

SNAP: Measurement of the Subjective Perception of the Symptom in Hereditary Spastic Paraparesis (HSP)

Who this might be right for
Hereditary Spastic Paraparesis
IRCCS Eugenio Medea 80
Not applicableLooking for participantsNCT05848271
What this trial is testing

Natural History Study of Patients with HPDL Mutations

Who this might be right for
Mitochondrial EncephalomyopathiesHereditary Spastic ParaplegiaSpastic Paraplegia+4 more
University of California, San Diego 50
Not applicableStudy completedNCT00023075
What this trial is testing

Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis

Who this might be right for
Primary Lateral SclerosisHereditary Spastic ParaplegiaAmyotrophic Lateral Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS) 55
Testing effectiveness (Phase 2)Study completedNCT02314208
What this trial is testing

Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5

Who this might be right for
Spastic Paraplegia, Hereditary
Institut National de la Santé Et de la Recherche Médicale, France 12
Not applicableLooking for participantsNCT06092346
What this trial is testing

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Who this might be right for
AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more
National Human Genome Research Institute (NHGRI)
Large-scale testing (Phase 3)Study completedNCT02604186
What this trial is testing

Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
University of Campinas, Brazil 55
Not applicableLooking for participantsNCT01568658
What this trial is testing

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Who this might be right for
Muscular DystrophiesMuscle MyopathiesHereditary Spastic Paraplegias+2 more
National Institute of Neurological Disorders and Stroke (NINDS) 9,300
Not applicableStudy completedNCT00136630
What this trial is testing

Natural History, Genetic Bases and Phenotype-genotype Correlations in Autosomal Dominant Spinocerebellar Degenerations

Who this might be right for
Spinocerebellar AtaxiasSpastic Paraplegias
Institut National de la Santé Et de la Recherche Médicale, France 175
Early research (Phase 1)Study completedNCT06117020
What this trial is testing

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Who this might be right for
Muscle SpasticityHypertonia, MuscleCerebral Palsy+5 more
Motric Bio 89
Testing effectiveness (Phase 2)UnknownNCT04101643
What this trial is testing

PCSK9 Inhibitor Treatment for Patients With SPG5

Who this might be right for
Hereditary Spastic Paraplegia Type 5
First Affiliated Hospital of Fujian Medical University 30
Not applicableLooking for participantsNCT05354622
What this trial is testing

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Who this might be right for
Hereditary Spastic ParaplegiaNeurodegenerative DiseasesPediatric Disorder+3 more
Boston Children's Hospital 200
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06948019
What this trial is testing

Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)

Who this might be right for
HSPHereditary Spastic ParaplegiaHereditary Spastic Paraparesis+10 more
BlackfinBio Ltd 5
Testing effectiveness (Phase 2)Study completedNCT03961906
What this trial is testing

Physiotherapy in Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
University Hospital Tuebingen 53
Not applicableLooking for participantsNCT04712812
What this trial is testing

Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic ParaplegiaSPG47SPG50+8 more
Boston Children's Hospital 700
Not applicableStudy completedNCT05373082
What this trial is testing

Identification of Modifying Factors in Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
Assistance Publique - Hôpitaux de Paris 311
Not applicableLooking for participantsNCT06229626
What this trial is testing

Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast

Who this might be right for
Hereditary Spastic Paraparesis
Assistance Publique - Hôpitaux de Paris 50
Not applicableLooking for participantsNCT06553976
What this trial is testing

Spastic Paraplegia - Centers of Excellence Research Network

Who this might be right for
Hereditary Spastic ParaplegiaPrimary Lateral SclerosisSPG4+6 more
Boston Children's Hospital 100
Not applicableEnded earlyNCT02859428
What this trial is testing

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Who this might be right for
Hereditary Spastic Paraplegia
National Institute of Neurological Disorders and Stroke (NINDS) 51
Not applicableStudy completedNCT03627416
What this trial is testing

Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy

Who this might be right for
Hereditary Spastic ParaplegiaAdrenomyeloneuropathy
Jakub Antczak 15
Not applicableLooking for participantsNCT06742697
What this trial is testing

Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
IRCCS Eugenio Medea 20
Load More Results
999