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Results for “Hereditary Spastic Paraplegias”

58 trials

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Showing 20 of 58 results

Large-scale testing (Phase 3)Study completedNCT02604186
What this trial is testing

Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
University of Campinas, Brazil 55
Testing effectiveness (Phase 2)Study completedNCT03961906
What this trial is testing

Physiotherapy in Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
University Hospital Tuebingen 53
Not applicableLooking for participantsNCT07417943
What this trial is testing

Neuromodulation to Enhance Motor Function in HSP

Who this might be right for
Hereditary Spastic Paraplegia
Rahul Sachdeva 15
Not applicableStudy completedNCT00677768
What this trial is testing

Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)

Who this might be right for
Amyotrophic Lateral SclerosisLou Gehrig's DiseasePrimary Lateral Sclerosis+2 more
Massachusetts General Hospital 475
Not applicableLooking for participantsNCT03206190
What this trial is testing

The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

Who this might be right for
Hereditary Spastic ParaplegiaHereditary, Spastic Paraplegia, Autosomal Dominant
University Hospital Tuebingen 200
Testing effectiveness (Phase 2)Study completedNCT04768166
What this trial is testing

Testing Miglustat Administration in Subjects With Spastic Paraplegia 11

Who this might be right for
Hereditary Spastic Paraparesis
IRCCS Fondazione Stella Maris 10
Not applicableStudy completedNCT07799233
What this trial is testing

Dental-Oral and Craniofacial Characteristics of Hereditary Spastic Paraplegia: A Preliminary Study

Who this might be right for
Hereditary Spastic Paraplegia
University of Barcelona 50
Not applicableLooking for participantsNCT03981276
What this trial is testing

Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders

Who this might be right for
Hereditary Spastic Paraplegia
Dr. Rebecca Schule 2,000
Large-scale testing (Phase 3)Looking for participantsNCT06692712
What this trial is testing

Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls.

Who this might be right for
Hereditary Spastic Paraplegia Type 50
Elpida Therapeutics SPC 24
Not applicableStudy completedNCT06740006
What this trial is testing

Retrospective Study on the WalkOn AFO in Children or Teenagers With Neurological Pathologies

Who this might be right for
Cerebral Palsy (CP)Spastic ParaplegiaSpinal Cord Injuries (SCI)+2 more
Otto Bock France SNC 65
Not applicableLooking for participantsNCT06572046
What this trial is testing

STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies

Who this might be right for
Hereditary Spastic Paraplegia
IRCCS Fondazione Stella Maris 500
Not applicableLooking for participantsNCT06092346
What this trial is testing

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Who this might be right for
AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more
National Human Genome Research Institute (NHGRI)
Not applicableLooking for participantsNCT04712812
What this trial is testing

Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic ParaplegiaSPG47SPG50+8 more
Boston Children's Hospital 700
Not applicableLooking for participantsNCT05354622
What this trial is testing

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Who this might be right for
Hereditary Spastic ParaplegiaNeurodegenerative DiseasesPediatric Disorder+3 more
Boston Children's Hospital 200
Not applicableStudy completedNCT05174403
What this trial is testing

Imaging Biomarkers in Spastic Paraplegia Type 5

Who this might be right for
Spastic Paraplegia Type 5A, Recessive
Assistance Publique - Hôpitaux de Paris 10
Testing effectiveness (Phase 2)UnknownNCT04101643
What this trial is testing

PCSK9 Inhibitor Treatment for Patients With SPG5

Who this might be right for
Hereditary Spastic Paraplegia Type 5
First Affiliated Hospital of Fujian Medical University 30
Not applicableStudy completedNCT03204773
What this trial is testing

Studying Non-motor Symptoms in HSP

Who this might be right for
SPG4
University Hospital Tuebingen 236
Not applicableLooking for participantsNCT07136844
What this trial is testing

Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

Who this might be right for
Neuromuscular DiseasesObesity (Disorder)Myotonic Dystrophy 1+9 more
Centre Hospitalier Universitaire de Liege 300
Not applicableLooking for participantsNCT06553976
What this trial is testing

Spastic Paraplegia - Centers of Excellence Research Network

Who this might be right for
Hereditary Spastic ParaplegiaPrimary Lateral SclerosisSPG4+6 more
Boston Children's Hospital 100
Not applicableLooking for participantsNCT07478172
What this trial is testing

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Who this might be right for
Neuromuscular Diseases (NMD)Amyotrophic Lateral SclerosisMyasthenia Gravis+15 more
University of Missouri-Columbia 50
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