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Results for “Hereditary Transthyretin Amyloid Neuropathy”

146 trials

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Showing 20 of 146 results

Testing effectiveness (Phase 2)Study completedNCT02595983
What this trial is testing

The Study of an Investigational Drug, Revusiran (ALN-TTRSC), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Whose Disease Has Continued to Worsen Following Liver Transplant

Who this might be right for
Transthyretin (TTR)-Mediated AmyloidosisFamilial Amyloidotic Polyneuropathy (FAP)ATTR Amyloidosis+1 more
Alnylam Pharmaceuticals 12
Large-scale testing (Phase 3)Looking for participantsNCT06672237
What this trial is testing

NTLA-2001 in ATTRv-PN

Who this might be right for
Neuromuscular DiseaseNeuromuscular Diseases (NMD)Neurodegenerative Disease+17 more
Intellia Therapeutics 60
Not applicableStudy completedNCT03190577
What this trial is testing

Assessment of the Prevalence of TTR Amyloid Neuropathy in a Population of Patients With Neuropathy of Unknown Aetiology

Who this might be right for
Familial Amyloid NeuropathyTransthyretin Amyloidosis
Nantes University Hospital 400
Very early researchStudy completedNCT03591757
What this trial is testing

Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (ATTR)

Who this might be right for
Transthyretin AmyloidosisAmyloidosis, Leptomeningeal, Transthyretin-Related
Boston University 10
Early research (Phase 1)Study completedNCT05201911
What this trial is testing

Characterize the Biodistribution of 124I-Labeled AT-03 in Patients With Systemic Amyloidosis

Who this might be right for
Amyloidosis; Systemic
Attralus, Inc. 13
Large-scale testing (Phase 3)Study completedNCT02791230
What this trial is testing

Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy

Who this might be right for
Transthyretin (TTR) Amyloid Cardiomyopathy
Pfizer 1,733
Large-scale testing (Phase 3)Study completedNCT03860935
What this trial is testing

Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy

Who this might be right for
AmyloidosisAmyloid CardiomyopathyTransthyretin Amyloidosis+2 more
Eidos Therapeutics, a BridgeBio company 632
Not applicableUnknownNCT04563286
What this trial is testing

Patient-Reported Outcome Measures in Wild-Type and Variant Cardiac Transthyretin Amyloidosis

Who this might be right for
Transthyretin Amyloidosis
University of Messina 250
Large-scale testing (Phase 3)Study completedNCT04136184
What this trial is testing

NEURO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

Who this might be right for
Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Ionis Pharmaceuticals, Inc. 168
Post-approval studies (Phase 4)Study completedNCT04828993
What this trial is testing

The Effect Of Tafamidis Meglumine In Transthyretin Amyloid Polyneuropathy Patients

Who this might be right for
Transthyretin Amyloid Polyneuropathy (ATTR-PN)
Pfizer 15
Not applicableLooking for participantsNCT07213297
What this trial is testing

Comprehensive Program for Hereditary Transthyretin Amyloidosis

Who this might be right for
Amyloidosis in Transthyretin (TTR)Amyloidosis, Familial
Hospital de Alta Complejidad en Red 20
Not applicableLooking for participantsNCT06034405
What this trial is testing

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

Who this might be right for
Lumbar Spinal StenosisCardiac AmyloidosisATTR Amyloidosis Wild Type+3 more
Columbia University 1,663
Not applicableApproved For MarketingNCT02939820
What this trial is testing

Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)

Who this might be right for
TTR-mediated AmyloidosisAmyloidosis, HereditaryAmyloid Neuropathies, Familial+3 more
Alnylam Pharmaceuticals
Not applicableLooking for participantsNCT04535349
What this trial is testing

Quantitative Analysis of Myocardial Uptake of Bone Radiopharmaceuticals in Patients With Cardiac ATTR Amyloidosis

Who this might be right for
Amyloidosis Transthyretin
University Hospital, Caen 35
Not applicableActive Not RecruitingNCT06360289
What this trial is testing

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Who this might be right for
Hereditary Amyloidosis, Transthyretin-RelatedAsymptomatic Carrier State
Alnylam Pharmaceuticals 346
Large-scale testing (Phase 3)Enrolling By InvitationNCT06679946
What this trial is testing

Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Alnylam Pharmaceuticals 700
Not applicableLooking for participantsNCT06291805
What this trial is testing

Phenotyping and Characterization of wtATTR-CM (TRACE 1)

Who this might be right for
Transthyretin AmyloidosisTransthyretin Amyloid CardiomyopathyWild-Type Transthyretin-Related (ATTR)Amyloidosis+1 more
Steen Hvitfeldt Poulsen 120
Large-scale testing (Phase 3)Not Yet RecruitingNCT07116473
What this trial is testing

To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)

Who this might be right for
Amyloidosis in Transthyretin (TTR)Amyloidosis, FamilialAmyloid Cardiomyopathy+7 more
Eidos Therapeutics, a BridgeBio company 250
Not applicableUnknownNCT05087953
What this trial is testing

Autonomic Evaluation of Patients With Hereditary Amyloidotic Cardiomyopathy: Hereditary Amyloidotic Heart Disease

Who this might be right for
Autonomic Nervous System DiseaseAmyloid Neuropathies
University of Sao Paulo General Hospital 60
Not applicableStudy completedNCT01705626
What this trial is testing

Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP)

Who this might be right for
Polyneuropathy, AmyloidNeuropathic PainCardiac Failure+2 more
CENTOGENE GmbH Rostock 500
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