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Results for “High-Frequency Microsatellite Instability”

205 trials

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Showing 20 of 205 results

Testing effectiveness (Phase 2)Looking for participantsNCT07140679
What this trial is testing

Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer

Who this might be right for
Localized Colon CarcinomaStage IIB Colon Cancer AJCC v8Stage IIC Colon Cancer AJCC v8+1 more
Emory University 40
Not applicableNot Yet RecruitingNCT07645742
What this trial is testing

Pilot Study of Intermittent Fasting With Immune Checkpoint Inhibitors

Who this might be right for
Cancer (Advanced Stage)
West Virginia University 90
Testing effectiveness (Phase 2)Looking for participantsNCT03667170
What this trial is testing

KN035 for dMMR/MSI-H Advanced Solid Tumors

Who this might be right for
Solid Tumor
3D Medicines (Sichuan) Co., Ltd. 200
Testing effectiveness (Phase 2)UnknownNCT04411524
What this trial is testing

The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSI-H Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer
Fudan University 50
Early research (Phase 1)Study completedNCT04242199
What this trial is testing

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorMSI-H/dMMR TumorsCutaneous Squamous Cell Carcinoma+9 more
Incyte Corporation 182
Testing effectiveness (Phase 2)WithdrawnNCT04001101
What this trial is testing

Anti-PD-1 +/- RT for MSI-H Solid Tumors

Who this might be right for
Microsatellite Instability HighMismatch Repair DeficiencyColorectal Cancer
University of Colorado, Denver
Testing effectiveness (Phase 2)Active Not RecruitingNCT07523763
What this trial is testing

Neoadjuvant Low-dose Immunotherapy in Locally Advanced MMR-deficient Colorectal Cancer

Who this might be right for
Colorectal Cancer (MSI-H)Colorectal Cancer (CRC)
Blokhin's Russian Cancer Research Center 30
Testing effectiveness (Phase 2)UnknownNCT04118933
What this trial is testing

PD-1 Antibody JS001 in MSI-H Advanced or Recurrent Colorectal Cancer

Who this might be right for
Colorectal Cancer
Xu jianmin 40
Testing effectiveness (Phase 2)UnknownNCT04866862
What this trial is testing

Fruquitinib Combined With Camrelizumab in Non MSI-H/dMMR Refractory Colorectal Cancer

Who this might be right for
Colorectal Neoplasm
The First Affiliated Hospital with Nanjing Medical University 32
Not applicableNot Yet RecruitingNCT07274657
What this trial is testing

Superb Microvascular Imaging (SMI) and Two-Dimensional Endoscopic Ultrasound Guided Shear Wave Elastography (2D-SWE-EUS) in Differential Diagnosis of Pancreatic Adenocarcinoma (PA) From Other Pancreatic Solid Lesions (PSLs) and Pancreatic neuroendocrinE Tumors (pNETs) Malignancy

Who this might be right for
Pancreas Adenocarcinoma (MSI-H)Pancreatic Neuroendocrine Tumors (pNET)
GCS Ramsay Santé pour l'Enseignement et la Recherche 150
Testing effectiveness (Phase 2)Looking for participantsNCT04114136
What this trial is testing

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Who this might be right for
MelanomaNSCLCHepatocellular Carcinoma+5 more
Dan Zandberg 72
Early research (Phase 1)Ended earlyNCT05909995
What this trial is testing

Interventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid Tumors

Who this might be right for
MelanomaHepatocellular Carcinoma (HCC)Renal Cell Carcinoma (RCC)+3 more
Incyte Corporation 8
Testing effectiveness (Phase 2)Looking for participantsNCT06002789
What this trial is testing

Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC

Who this might be right for
Multiple CancerColorectal Cancer
Sixth Affiliated Hospital, Sun Yat-sen University 17
Large-scale testing (Phase 3)Active Not RecruitingNCT05890742
What this trial is testing

A Clinical Trial Evaluating the Efficacy and Safety of IBI310 in Combination With Sintilimab, for Neoadjuvant Treatment of MSI-H/dMMR Resectable Colon Cancer

Who this might be right for
MSI-H
Innovent Biologics (Suzhou) Co. Ltd. 453
Testing effectiveness (Phase 2)Active Not RecruitingNCT05879822
What this trial is testing

Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive

Who this might be right for
Advanced Solid Tumor
Incyte Corporation 73
Large-scale testing (Phase 3)Active Not RecruitingNCT02997228
What this trial is testing

Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT Study

Who this might be right for
Metastatic Colorectal AdenocarcinomaStage IV Colorectal Cancer AJCC v7
National Cancer Institute (NCI) 120
Large-scale testing (Phase 3)Looking for participantsNCT06686576
What this trial is testing

Neoadjuvant QL1706 in Participants With Untreated dMMR/MSI-H Resectable Colon Cancer

Who this might be right for
Colon Cancer
Qilu Pharmaceutical Co., Ltd. 363
Not applicableStudy completedNCT05162248
What this trial is testing

Microsatellite Instability in Colorectal Cancers

Who this might be right for
Colorectal CancerColorectal CarcinomaMicrosatellite Instability High+2 more
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey 231
Testing effectiveness (Phase 2)Active Not RecruitingNCT07160647
What this trial is testing

The Efficacy and Safety of Neoadjuvant Therapy With Iparomlimab and Tuvonralimab in Locally Advanced MSI-H/dMMR Colorectal Cancer: An Prospective, Single-Arm Study (Neo-IT)

Who this might be right for
dMMR/MSI-H-type Rectal Adenocarcinoma
Sir Run Run Shaw Hospital 29
Early research (Phase 1)Study completedNCT04440943
What this trial is testing

The PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies

Who this might be right for
Non-small Cell Lung CancerBreast CancerGastric Cancer+11 more
Celldex Therapeutics 27
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