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Results for “High-Risk Myelodysplastic Syndromes”

581 trials

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Showing 20 of 581 results

Testing effectiveness (Phase 2)Ended earlyNCT01748240
What this trial is testing

Addition of Vorinostat to Azacitidine in Higher Risk MDS a Phase II add-on Study in Patients With Azacitidine Failure

Who this might be right for
Myelodysplastic Syndrome
Groupe Francophone des Myelodysplasies 21
Early research (Phase 1)Study completedNCT01149915
What this trial is testing

Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias

Who this might be right for
Acute Myelogenous LeukemiaAcute Lymphoblastic LeukemiaChronic Myelogenous Leukemia+3 more
Threshold Pharmaceuticals 40
Testing effectiveness (Phase 2)Study completedNCT00863148
What this trial is testing

Allogeneic Stem Cell Transplant With Clofarabine, Busulfan and Antithymocyte Globulin (ATG) for Adult Patients With High-risk Acute Myeloid Leukemia/Myelodysplastic Syndromes (AML/MDS) or Acute Lymphoblastic Leukemia (ALL)

Who this might be right for
MDSAMLALL+1 more
Nantes University Hospital 30
Testing effectiveness (Phase 2)Study completedNCT00003335
What this trial is testing

Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer

Who this might be right for
Graft Versus Host DiseaseLeukemiaLymphoma+2 more
Case Comprehensive Cancer Center 44
Testing effectiveness (Phase 2)WithdrawnNCT00003984
What this trial is testing

Monoclonal Antibody Therapy in Treating Patients With Primary Myelodysplastic Syndrome

Who this might be right for
Myelodysplastic Syndromes
European Organisation for Research and Treatment of Cancer - EORTC
Large-scale testing (Phase 3)Ended earlyNCT02158936
What this trial is testing

Eltrombopag or Placebo in Combination With Azacitidine in Subjects With International Prognostic Scoring System (IPSS) Intermediate-1, Intermediate-2 or High-risk Myelodysplastic Syndromes (MDS)

Who this might be right for
Thrombocytopaenia
Novartis Pharmaceuticals 356
Testing effectiveness (Phase 2)WithdrawnNCT04044209
What this trial is testing

The IDH1 Inhibitor AG-120 in Combination With the Checkpoint Blockade Inhibitor, Nivolumab, for Patients With IDH1 Mutated Relapsed/Refractory AML and High Risk MDS

Who this might be right for
Myelodysplastic SyndromesAcute Myeloid Leukemia
Yale University
Testing effectiveness (Phase 2)Study completedNCT00065143
What this trial is testing

Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome

Who this might be right for
Leukemia, MyeloidMyelodysplastic Syndromes
M.D. Anderson Cancer Center 60
Testing effectiveness (Phase 2)Active Not RecruitingNCT01885689
What this trial is testing

Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia

Who this might be right for
Adult Acute Lymphoblastic Leukemia in RemissionAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAdult Acute Myeloid Leukemia in Remission+4 more
City of Hope Medical Center
Early research (Phase 1)Study completedNCT02485535
What this trial is testing

Selinexor in Treating Patients With Intermediate- and High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome After Transplant

Who this might be right for
Acute Myeloid Leukemiade Novo Myelodysplastic SyndromeMyelodysplastic Syndrome+2 more
University of Chicago 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT04900350
What this trial is testing

A Trial of AK117 (Anti-CD47) in Patients With Myelodysplastic Syndrome

Who this might be right for
Myelodysplastic Syndrome
Akeso 136
Testing effectiveness (Phase 2)Study completedNCT00475150
What this trial is testing

Cediranib Maleate in Treating Patients With Relapsed, Refractory, or Untreated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Who this might be right for
Adult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)+8 more
National Cancer Institute (NCI) 39
Testing effectiveness (Phase 2)Study completedNCT02169791
What this trial is testing

Nonmyeloablative Haploidentical Transplant Followed by MLN9708

Who this might be right for
Acute LeukemiaChronic LeukemiaMyelodysplastic Syndrome+2 more
Northside Hospital, Inc. 29
Early research (Phase 1)WithdrawnNCT03057990
What this trial is testing

Pyrimethamine for Intermediate/High-risk Myelodysplastic Syndromes (MDS)

Who this might be right for
Myelodysplastic Syndromes
Montefiore Medical Center
Early research (Phase 1)Ended earlyNCT00376519
What this trial is testing

Umbilical Cord Blood T-Regulatory Cell Infusion Followed by Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Leukemia or Other Hematologic Diseases

Who this might be right for
Graft Versus Host DiseaseLeukemiaLymphoma+3 more
Masonic Cancer Center, University of Minnesota 3
Not applicableStudy completedNCT00296023
What this trial is testing

Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer

Who this might be right for
Chronic Myeloproliferative DisordersLeukemiaLymphoma+2 more
University of California, San Francisco 25
Testing effectiveness (Phase 2)Study completedNCT00774046
What this trial is testing

High-dose Cytarabine/Mitoxantrone Followed by Autotransplantation for t-MDS/t-AML

Who this might be right for
Myelodysplastic SyndromeAcute Myeloid Leukemia
University of Chicago 32
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07672769
What this trial is testing

Bexmarilimab + Azacitidine Versus Placebo + Azacitidine in Participants With Treatment-naïve Higher-risk Myelodysplastic Syndromes

Who this might be right for
Higher Risk Myelodysplastic Syndromes
Faron Pharmaceuticals Ltd 90
Testing effectiveness (Phase 2)Study completedNCT00045396
What this trial is testing

A Phase II Study Of The Farnesyltransferase Inhibitor ZANESTRA (R115777, NSC #702818, IND #58,359) In Complete Remission Following Induction And/Or Consolidation Chemotherapy In Adults With Poor-Risk Acute Myelogenous Leukemia (AML) And High-Risk Myelodysplasia (MDS)

Who this might be right for
Adult Acute Myeloid Leukemia in RemissionAdult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Del(5q)+6 more
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)Study completedNCT02044796
What this trial is testing

Filgrastim, Cladribine, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Newly Diagnosed or Relapsed/Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

Who this might be right for
Acute Biphenotypic Leukemiade Novo Myelodysplastic SyndromePreviously Treated Myelodysplastic Syndrome+3 more
Fred Hutchinson Cancer Center 199
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