Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “High-grade Gliomas (HGG)”

78 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 78 results

Very early researchActive Not RecruitingNCT03893487
What this trial is testing

Fimepinostat in Treating Brain Tumors in Children and Young Adults

Who this might be right for
Diffuse Intrinsic Pontine GliomaRecurrent Anaplastic AstrocytomaRecurrent Glioblastoma+2 more
Sabine Mueller, MD, PhD 30
Testing effectiveness (Phase 2)Study completedNCT03879512
What this trial is testing

Autologous Dendritic Cells, Metronomic Cyclophosphamide and Checkpoint Blockade in Children With Relapsed HGG

Who this might be right for
Childhood Glioblastoma
Wuerzburg University Hospital 24
Testing effectiveness (Phase 2)Active Not RecruitingNCT03919071
What this trial is testing

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

Who this might be right for
Anaplastic AstrocytomaAnaplastic Astrocytoma, Not Otherwise SpecifiedAnaplastic Ganglioglioma+5 more
National Cancer Institute (NCI) 58
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07751744
What this trial is testing

Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma

Who this might be right for
Brain Metastases From Solid TumorsLeptomeningeal DiseaseHigh Grade Glioma (HGG)+1 more
Jubilant Therapeutics Inc. 113
Early research (Phase 1)Looking for participantsNCT07179328
What this trial is testing

Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

Who this might be right for
GBMGlioblastoma Multiforme (GBM)Glioblastoma Multiforme of Brain+5 more
Sunnybrook Health Sciences Centre 10
Early research (Phase 1)Active Not RecruitingNCT04323046
What this trial is testing

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

Who this might be right for
GlioblastomaMalignant GliomaRecurrent Glioblastoma+3 more
Sabine Mueller, MD, PhD 9
Testing effectiveness (Phase 2)Ended earlyNCT03973918
What this trial is testing

Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG

Who this might be right for
High Grade GliomaBRAF V600EBRAF V600K+4 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 5
Testing effectiveness (Phase 2)Looking for participantsNCT05099003
What this trial is testing

The Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Who this might be right for
Malignant Glioma
National Cancer Institute (NCI) 132
Testing effectiveness (Phase 2)Ended earlyNCT02607124
What this trial is testing

A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy

Who this might be right for
High Grade GliomaDiffuse Intrinsic Pontine GliomaBithalamic High Grade Glioma
Children's Hospital Medical Center, Cincinnati 11
Early research (Phase 1)Looking for participantsNCT06305910
What this trial is testing

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantRecurrent High Grade Glioma
OX2 Therapeutics 24
Early research (Phase 1)Study completedNCT03355794
What this trial is testing

Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

Who this might be right for
Diffuse Intrinsic Pontine GliomaMalignant Glioma of BrainHigh Grade Glioma+4 more
Children's Hospital Medical Center, Cincinnati 19
Early research (Phase 1)Study completedNCT05362409
What this trial is testing

Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma

Who this might be right for
High Grade Glioma
Alpheus Medical, Inc. 22
Early research (Phase 1)Looking for participantsNCT07544992
What this trial is testing

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma, IDH-Wildtype
City of Hope Medical Center 24
Large-scale testing (Phase 3)UnknownNCT03243461
What this trial is testing

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)

Who this might be right for
Glioblastoma WHO Grade IVDiffuse Midline Glioma Histone 3 K27M WHO Grade IVAnaplastic Astrocytoma WHO Grade III+2 more
University of Göttingen 167
Not applicableStudy completedNCT00561873
What this trial is testing

Nimotuzumab in Children With HGG

Who this might be right for
High Grade Glioma
Oncoscience AG 45
Testing effectiveness (Phase 2)Active Not RecruitingNCT04201457
What this trial is testing

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Who this might be right for
Low Grade Glioma (LGG) of Brain With BRAF AberrationHigh Grade Glioma (HGG) of the Brain With BRAF AberrationLow Grade Glioma of Brain With Neurofibromatosis Type 1
Pediatric Brain Tumor Consortium 57
Not applicableActive Not RecruitingNCT07042620
What this trial is testing

Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

Who this might be right for
Brain Tumor AdultLow Grade Glioma (LGG), High Grade Glioma (HGG)Glioblastoma
SonoClear AS 15
Early research (Phase 1)Study completedNCT02473380
What this trial is testing

Fluorescence Spectroscopy Guided Surgery

Who this might be right for
Low Grade Glioma (LGG)High Grade Glioma (HGG)
Hospices Civils de Lyon 11
Testing effectiveness (Phase 2)Enrolling By InvitationNCT07126990
What this trial is testing

Clinical Study of a Novel Oncolytic Virus Ad-TD-nsIL12 in the Treatment of Primary High-grade Glioma

Who this might be right for
Glioma
Xiaorong Wu 40
Not applicableStudy completedNCT00840554
What this trial is testing

The Effects of Adding a Home Exercise Program to a Clinical Physical Therapy Program on Cancer-Related Fatigue

Who this might be right for
Fatigue
University of Florida 20
Next Page