Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “High-risk Locally Advanced Colorectal Cancer”

57 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 57 results

Testing effectiveness (Phase 2)Looking for participantsNCT06903858
What this trial is testing

Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer

Who this might be right for
Colorectal CancerMicrosatellite Instability HighMismatch Repair Deficiency
Sun Yat-sen University 105
Testing effectiveness (Phase 2)Looking for participantsNCT07176182
What this trial is testing

Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression

Who this might be right for
Rectal Cancer PatientsRectal Cancer Stage IIRectal Cancer Stage III
Sixth Affiliated Hospital, Sun Yat-sen University 236
Testing effectiveness (Phase 2)Looking for participantsNCT06923345
What this trial is testing

Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)

Who this might be right for
Rectal CancerNeoadjuvant TherapiesImmune Checkpoint Therapy+1 more
Sixth Affiliated Hospital, Sun Yat-sen University 80
Testing effectiveness (Phase 2)UnknownNCT04838496
What this trial is testing

Induction Chemotherapy for Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Catharina Ziekenhuis Eindhoven 128
Large-scale testing (Phase 3)Active Not RecruitingNCT00569127
What this trial is testing

Octreotide Acetate and Recombinant Interferon Alfa-2b or Bevacizumab in Treating Patients With Metastatic or Locally Advanced, High-Risk Neuroendocrine Tumor

Who this might be right for
Colorectal Neuroendocrine Tumor G1Gastric Neuroendocrine Tumor G1Neuroendocrine Neoplasm+2 more
National Cancer Institute (NCI) 427
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06599827
What this trial is testing

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC

Who this might be right for
Rectal Cancer
Shanghai Zhongshan Hospital 54
Testing effectiveness (Phase 2)Looking for participantsNCT07410494
What this trial is testing

Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors

Who this might be right for
CancerBreast CancerNon-Small Cell Lung Cancer (NSCLC)+10 more
Essen Biotech 85
Testing effectiveness (Phase 2)Study completedNCT02340949
What this trial is testing

Induction FOLFOX With or Without Aflibercept Followed by Chemoradiation in High Risk Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Grupo Espanol Multidisciplinario del Cancer Digestivo 180
Testing effectiveness (Phase 2)Looking for participantsNCT07279077
What this trial is testing

Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial

Who this might be right for
Colon CancerNeoadjuvant TherapiesImmune Checkpoint Therapy+1 more
Sixth Affiliated Hospital, Sun Yat-sen University 38
Large-scale testing (Phase 3)Not Yet RecruitingNCT07740720
What this trial is testing

The Duration of Dostarlimab in Untreated Mismatch Repair Deficient (dMMR)/ Microsatellite Instability-high (MSI-H) Locally Advanced Rectal Cancer

Who this might be right for
Neoplasms, Rectal
GlaxoSmithKline 90
Testing effectiveness (Phase 2)Looking for participantsNCT03926338
What this trial is testing

Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer

Who this might be right for
Colorectal CancerMismatch Repair-deficient (dMMR)Microsatellite Instability-high (MSI-H)+1 more
Sun Yat-sen University 270
Testing effectiveness (Phase 2)Study completedNCT01892527
What this trial is testing

Study of Tivantinib (ARQ 197) Plus Cetuximab in EGFR Inhibitor-Resistant MET High Subjects

Who this might be right for
Colorectal Cancer MetastaticC-met Overexpression
Armando Santoro, MD 43
Testing effectiveness (Phase 2)Study completedNCT02569645
What this trial is testing

Rosuvastatin in the Treatment of Rectal Cancer

Who this might be right for
Rectal Cancer
AHS Cancer Control Alberta 45
Not applicableLooking for participantsNCT07474103
What this trial is testing

SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC

Who this might be right for
Rectal Cancer, Adenocarcinoma
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 49
Large-scale testing (Phase 3)Not Yet RecruitingNCT06443671
What this trial is testing

Neoadjuvant Fruquintinib Plus Tislelizumab Combined With mCapeOX Versus CapeOX for Mid-high pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Peking University Cancer Hospital & Institute 132
Testing effectiveness (Phase 2)Ended earlyNCT04258111
What this trial is testing

IBI310 in Combination with Sintilimab in Patients with DNA Mismatch Repair Deficient (dMMR)/microsatellite Instability High (MSI-H) Locally-advanced or Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Innovent Biologics (Suzhou) Co. Ltd. 4
Testing effectiveness (Phase 2)Ended earlyNCT03170115
What this trial is testing

Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer

Who this might be right for
Rectal Cancer, AdenocarcinomaLocally Advanced Malignant NeoplasmChemoradiation
Instituto Nacional de Cancer, Brazil 25
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07580339
What this trial is testing

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 30
Large-scale testing (Phase 3)UnknownNCT03177382
What this trial is testing

Total Neoadjuvant Treatment vs. Chemoradiotherapy in Local Advanced Rectal Cancer With High Risk Factors

Who this might be right for
Total Neoadjuvant TreatmentChemoradiotherapyLocal Advanced Rectal Cancer+1 more
West China Hospital 458
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07527520
What this trial is testing

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial

Who this might be right for
Rectal CancerModerately Hypofractionated RadiotherapySerplulimab+1 more
Fudan University 165
Next Page