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Results for “High-risk Myeloproliferative Neoplasm (MPN)”

13 trials

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Showing 13 of 13 results

Early research (Phase 1)Not Yet RecruitingNCT07565220
What this trial is testing

Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic Malignancies

Who this might be right for
Acute Lymphocytic Leukemia (ALL)Acute Myeloid Leukemia (AML)Acute Leukemia+2 more
Sawa Ito, MD 48
Large-scale testing (Phase 3)Study completedNCT03952039
What this trial is testing

An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

Who this might be right for
Primary MyelofibrosisPost-Polycythemia VeraMyelofibrosis
Celgene 202
Testing effectiveness (Phase 2)Study completedNCT02125318
What this trial is testing

Anagrelide Controlled Release (GALE-401) in Patients With High Platelet Counts Due to Bone Marrow Disorders

Who this might be right for
ThrombocytosisMyeloproliferative Neoplasms
Galena Biopharma, Inc. 18
Large-scale testing (Phase 3)Looking for participantsNCT06740916
What this trial is testing

Long-term Efficacy of Once Daily Versus Twice Daily Aspirin in High-risk MPN Patients With Aspirin Resistance

Who this might be right for
Myeloproliferative Neoplasms (MPN)
Siriraj Hospital 240
Testing effectiveness (Phase 2)Looking for participantsNCT05817955
What this trial is testing

Clinical Study of Azacitidine Combined With Ruxolitinib in the Treatment of Higher-risk MDS/MPN

Who this might be right for
MDS/MPN
The First Affiliated Hospital with Nanjing Medical University 50
Not applicableStudy completedNCT02953704
What this trial is testing

Myelofibrosis and Essential Thrombocythemia Observational Study (MOST)

Who this might be right for
MPN (Myeloproliferative Neoplasms)
Incyte Corporation 1,469
Early research (Phase 1)Looking for participantsNCT07469891
What this trial is testing

PRT12396 in Participants With Select Myeloproliferative Neoplasms

Who this might be right for
Polycythemia Vera (PV)Myelofibrosis (MF)Myeloproliferative Neoplasms (MPNs)+3 more
Prelude Therapeutics 100
Large-scale testing (Phase 3)Ended earlyNCT03755518
What this trial is testing

A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

Who this might be right for
Primary MyelofibrosisPost-Polycythemia Vera MyelofibrosisMyelofibrosis+1 more
Celgene 38
Early research (Phase 1)WithdrawnNCT02564536
What this trial is testing

Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)

Who this might be right for
Chronic Myelomonocytic LeukemiaJuvenile Myelomonocytic LeukemiaAtypical Chronic Myeloid Leukemia+3 more
Washington University School of Medicine
Early research (Phase 1)Active Not RecruitingNCT03613532
What this trial is testing

Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+2 more
Jacqueline Garcia, MD 102
Not applicableLooking for participantsNCT07362225
What this trial is testing

MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)

Who this might be right for
Polycythemia VeraET (Essential Thrombocythemia)Polycythemia Vera (PV)+52 more
MPN Research Foundation 5,000
Testing effectiveness (Phase 2)Looking for participantsNCT04996875
What this trial is testing

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

Who this might be right for
Advanced Systemic Mastocytosis (AdvSM)SM With an Associated Hematologic Neoplasm (SM-AHN)Mast Cell Leukemia (MCL)+1 more
Cogent Biosciences, Inc. 140
Testing effectiveness (Phase 2)Looking for participantsNCT06523556
What this trial is testing

Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia

Who this might be right for
Atypical Chronic Myeloid LeukemiaChronic Myelomonocytic LeukemiaMyelodysplastic/Myeloproliferative Neoplasm+5 more
Uma Borate 52