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Results for “Homologous Recombination Genes”

38 trials

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Showing 20 of 38 results

Testing effectiveness (Phase 2)Study completedNCT02952534
What this trial is testing

Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

Who this might be right for
Metastatic Castration Resistant Prostate Cancer
pharmaand GmbH 277
Not applicableStudy completedNCT04651920
What this trial is testing

A Study on Association Between HR Genes and the HRD Status in Chinese Epithelial Ovarian Cancer

Who this might be right for
Epithelial Ovarian CancerChineseHomologous Recombination Deficiency+4 more
Lei Li 240
Not applicableStudy completedNCT04962880
What this trial is testing

HRR Prevalence in LatAm PROSPECT Study

Who this might be right for
Castration-resistant Prostate Cancer
AstraZeneca 388
Not applicableStudy completedNCT05775549
What this trial is testing

Characterize the Outcomes of Olaparib Maintenance Monotherapy in Newly Diagnosed BRCAwt Ovarian Cancer

Who this might be right for
Advanced Ovarian Cancer
AstraZeneca 24
Not applicableStudy completedNCT04425200
What this trial is testing

Prevalence of HRR-related Genes Mutations and Prognosis in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients in Real World Setting

Who this might be right for
Prostatic Neoplasms
AstraZeneca 205
Not applicableNot Yet RecruitingNCT05901025
What this trial is testing

Homologous Recombination Repair Pathway Gene Mutation Spectrum in Chinese Breast Cancer Patients

Who this might be right for
Breast Cancer
Shanghai Jiao Tong University School of Medicine 5,000
Testing effectiveness (Phase 2)WithdrawnNCT03432676
What this trial is testing

Epacadostat and Pembrolizumab in Treating Participants With Advanced Pancreatic Cancer

Who this might be right for
ATM Gene MutationDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+7 more
M.D. Anderson Cancer Center
Not applicableStudy completedNCT05415787
What this trial is testing

Evaluation of the Technical Feasibility of Testing ct DNA for Homologous Recombination Gene Variants in Metastatic Prostate Cancer.

Who this might be right for
Circulating Tumor DNAMetastatic Prostate Cancer
University Hospital, Tours 40
Testing effectiveness (Phase 2)UnknownNCT04822961
What this trial is testing

Senaparib in mCRPC Patients With Homologous Recombination Repair Gene Alterations After Docetaxel Treatment

Who this might be right for
mCRPC
Impact Therapeutics, Inc. 285
Large-scale testing (Phase 3)UnknownNCT04473339
What this trial is testing

Prospective Trail of HIPEC in Recurrent Ovarian Cancer Patients With HRR Mutation

Who this might be right for
Ovarian CancerEpithelial Ovarian CancerOvarian Cancer, Epithelial+2 more
CAI Hongbing 280
Large-scale testing (Phase 3)Study completedNCT02975934
What this trial is testing

Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

Who this might be right for
Metastatic Castration Resistant Prostate Cancer
pharmaand GmbH 405
Large-scale testing (Phase 3)UnknownNCT04337632
What this trial is testing

Evaluation of the Sensitivity to Different Chemotherapy Regimens in Platinum-Partial Sensitive Recurrent Ovarian Cancer

Who this might be right for
Ovarian Cancer
Hunan Cancer Hospital 338
Testing effectiveness (Phase 2)Study completedNCT03377556
What this trial is testing

Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer

Who this might be right for
ATM Gene MutationATR Gene MutationBARD1 Gene Mutation+18 more
SWOG Cancer Research Network 51
Testing effectiveness (Phase 2)Study completedNCT03652493
What this trial is testing

Trial Evaluating the Efficacy of CARBOPLATIN in Metastatic Prostate Cancer With Gene Alterations in the Homologous Recombination Pathway

Who this might be right for
Castration-resistant Prostate CancerMetastasis
Centre Francois Baclesse 16
Not applicableStudy completedNCT04716374
What this trial is testing

Pathogenic Variants in Homologous Recombination Repair Genes in Patients With Epithelial Ovarian Cancer

Who this might be right for
Epithelial Ovarian Cancer
Hellenic Cooperative Oncology Group 550
Testing effectiveness (Phase 2)Active Not RecruitingNCT05689021
What this trial is testing

CJNJ-67652000 and Prednisone for Treatment of Metastatic Castration-Resistant Prostate Cancer and SPOP Gene Mutations

Who this might be right for
Castration-Resistant Prostate CarcinomaMetastatic Prostate AdenocarcinomaStage IVB Prostate Cancer AJCC v8
Mayo Clinic 8
Not applicableLooking for participantsNCT05466786
What this trial is testing

Distribution of the Homologous Recombination-related (HRR) Genesmutationsand HRD in Breast Cancer

Who this might be right for
Breast CancerHER2-low Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University 255
Testing effectiveness (Phase 2)WithdrawnNCT06392841
What this trial is testing

Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations

Who this might be right for
Metastatic Hormone-sensitive Prostate Cancer (mHSPC)Deleterious HRR Gene MutationBRCA1 Gene Mutation+7 more
Qian Qin
Large-scale testing (Phase 3)Active Not RecruitingNCT04497844
What this trial is testing

Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Who this might be right for
Metastatic Castration-sensitive Prostate Cancer
Janssen Research & Development, LLC 696
Early research (Phase 1)Looking for participantsNCT06177171
What this trial is testing

Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

Who this might be right for
BRCA1 MutationBRCA2 MutationBRCA Mutation+3 more
Pamela Munster 18
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