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Results for “IDH Mutation”

56 trials

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Showing 20 of 56 results

Not applicableLooking for participantsNCT03684109
What this trial is testing

Non-invasive Glioma Characterization Through Molecular Imaging

Who this might be right for
GliomaBrain TumorPrimary Brain Tumor+2 more
University of Miami 30
Large-scale testing (Phase 3)Looking for participantsNCT06387069
What this trial is testing

Evaluate HMPL-306 in Patients With IDH1or IDH2-mutated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia
Hutchmed 316
Testing effectiveness (Phase 2)Active Not RecruitingNCT02677922
What this trial is testing

Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Who this might be right for
Leukemia, Myeloid, Acute
Celgene 130
Testing effectiveness (Phase 2)Active Not RecruitingNCT06478212
What this trial is testing

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

Who this might be right for
IDH1-mutant GliomaIDH2-mutant Glioma
Institut de Recherches Internationales Servier 51
Large-scale testing (Phase 3)Active Not RecruitingNCT06780930
What this trial is testing

Phase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 orIDH2 Mutation

Who this might be right for
Residual or Recurrent Grade 2 IDH Mutant Glioma
Servier 57
Not applicableStudy completedNCT01385150
What this trial is testing

Biomarkers in Blood Samples From Patients With Acute Myeloid Leukemia

Who this might be right for
Leukemia
Eastern Cooperative Oncology Group 220
Not applicableNot Yet RecruitingNCT07439302
What this trial is testing

Monitoring of Neurological Symptoms, Treatment Tolerance, and Quality of Life Using the Resilience PRO Electronic Patient-reported Outcome Application in Patients With IDH-mutated Glioma

Who this might be right for
OncologyGlioma
Assistance Publique - Hôpitaux de Paris 80
Very early researchLooking for participantsNCT05851378
What this trial is testing

Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma

Who this might be right for
Adult Gliomas, Mixed
Robert Bok, MD, PhD 40
Early research (Phase 1)Looking for participantsNCT02074839
What this trial is testing

Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

Who this might be right for
Relapsed or Refractory Acute Myeloid Leukemia (AML)Untreated AMLOther IDH1-mutated Positive Hematologic Malignancies+1 more
Institut de Recherches Internationales Servier 291
Not applicableLooking for participantsNCT06180434
What this trial is testing

Short Term Outcomes After PRoton and PhotoN RadiOtherapy for IDH Mutated Grade 2 and 3 Gliomas

Who this might be right for
GliomaRadiotherapy; Complications
Erasmus Medical Center 320
Testing effectiveness (Phase 2)Study completedNCT02719574
What this trial is testing

Open-label Study of FT-2102 With or Without Azacitidine or Cytarabine in Patients With AML or MDS With an IDH1 Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Myelogenous LeukemiaMyelodysplastic Syndrome
Forma Therapeutics, Inc. 336
Not applicableUnknownNCT04369287
What this trial is testing

Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaIDH1 Gene MutationIDH2 Gene Mutation
Istituto Clinico Humanitas 654
Testing effectiveness (Phase 2)Looking for participantsNCT03991832
What this trial is testing

Study of Olaparib and Durvalumab in IDH-Mutated Solid Tumors

Who this might be right for
GliomaCholangiocarcinomaSolid Tumor+1 more
University Health Network, Toronto 58
Testing effectiveness (Phase 2)Active Not RecruitingNCT03953898
What this trial is testing

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAcute Myeloid Leukemia Post Cytotoxic Therapy+4 more
National Cancer Institute (NCI) 14
Large-scale testing (Phase 3)Ended earlyNCT03763422
What this trial is testing

Trial in Low Grade Glioma Patients: Wait or Treat

Who this might be right for
Low-grade GliomaTemozolomidePhase III+1 more
European Organisation for Research and Treatment of Cancer - EORTC 19
Early research (Phase 1)Active Not RecruitingNCT02381886
What this trial is testing

IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

Who this might be right for
Advanced Malignancies That Harbor IDHR132 Mutations
Novartis Pharmaceuticals 166
Not applicableLooking for participantsNCT07405372
What this trial is testing

Construction and Application of an IDH Mutation-Targeted PET/MRI Imaging Framework for Precision Diagnosis of Gliomas

Who this might be right for
Glioma
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 10
Early research (Phase 1)Active Not RecruitingNCT03528642
What this trial is testing

Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Who this might be right for
Astrocytoma, IDH-Mutant, Grade 2Astrocytoma, IDH-Mutant, Grade 3
National Cancer Institute (NCI) 40
Early research (Phase 1)Active Not RecruitingNCT04603001
What this trial is testing

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+1 more
Eli Lilly and Company 260
Not applicableActive Not RecruitingNCT06481345
What this trial is testing

Characterization of Myeloproliferative Neoplasia With a Mutated IDH, SRSF2 or SF3B1 Allele (CARPEDIEM)

Who this might be right for
Myeloproliferative Disorders
University Hospital, Brest 300
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