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Results for “IDH Mutation”

53 trials

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Showing 20 of 53 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT06478212
What this trial is testing

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

Who this might be right for
IDH1-mutant GliomaIDH2-mutant Glioma
Institut de Recherches Internationales Servier 51
Testing effectiveness (Phase 2)UnknownNCT02209428
What this trial is testing

A Prospective Cohort to Study the Effect of Temozolomide on IDH Mutational Low Grade Gliomas

Who this might be right for
AstrocytomaOligodendrogliomaOligoastrocytoma
Huashan Hospital 54
Early research (Phase 1)Active Not RecruitingNCT03528642
What this trial is testing

Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Who this might be right for
Astrocytoma, IDH-Mutant, Grade 2Astrocytoma, IDH-Mutant, Grade 3
National Cancer Institute (NCI) 40
Not applicableActive Not RecruitingNCT06481345
What this trial is testing

Characterization of Myeloproliferative Neoplasia With a Mutated IDH, SRSF2 or SF3B1 Allele (CARPEDIEM)

Who this might be right for
Myeloproliferative Disorders
University Hospital, Brest 300
Early research (Phase 1)Ended earlyNCT04762602
What this trial is testing

HMPL-306 in Advanced Solid Tumors With IDH Mutations

Who this might be right for
Isocitrate Dehydrogenase Gene Mutation
Hutchmed 42
Not applicableStudy completedNCT01385150
What this trial is testing

Biomarkers in Blood Samples From Patients With Acute Myeloid Leukemia

Who this might be right for
Leukemia
Eastern Cooperative Oncology Group 220
Very early researchLooking for participantsNCT05851378
What this trial is testing

Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma

Who this might be right for
Adult Gliomas, Mixed
Robert Bok, MD, PhD 40
Large-scale testing (Phase 3)Not Yet RecruitingNCT07215910
What this trial is testing

Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

Who this might be right for
Astrocytoma, IDH-Mutant, Grade 3
Alliance for Clinical Trials in Oncology 408
Very early researchWithdrawnNCT05061251
What this trial is testing

Surgical Window of Opportunity Study of Orally Administered BAY 2402234 in Recurrent Glioma

Who this might be right for
GliomaIDH Mutation
University of Texas Southwestern Medical Center
Testing effectiveness (Phase 2)Looking for participantsNCT05345002
What this trial is testing

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

Who this might be right for
GliomaIDH MutationAstrocytoma+1 more
Stephen Bagley, MD, MSCE 55
Very early researchLooking for participantsNCT06636162
What this trial is testing

Window of Opportunity Study of DSP-0390 in Gliomas

Who this might be right for
Glioma, MalignantGrade II GliomaIDH Mutation
Washington University School of Medicine 20
Early research (Phase 1)Active Not RecruitingNCT02632708
What this trial is testing

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

Who this might be right for
Newly Diagnosed Acute Myeloid Leukemia (AML)Untreated AMLAML Arising From Myelodysplastic Syndrome (MDS)+2 more
Institut de Recherches Internationales Servier 153
Testing effectiveness (Phase 2)Study completedNCT04740190
What this trial is testing

Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd

Who this might be right for
Recurrent GliomaRecurrent GlioblastomaPoly ADP Ribose Polymerase (PARP) Inhibitor+2 more
The University of Hong Kong 33
Early research (Phase 1)Active Not RecruitingNCT05441514
What this trial is testing

Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Who this might be right for
Recurrent Acute Myeloid LeukemiaRefractory Acute Myeloid Leukemia
City of Hope Medical Center 3
Not applicableNot Yet RecruitingNCT07017790
What this trial is testing

Amino Acid PET to Assess the Efficacy of IDH Inhibitor Treatments for IDH Mutated Gliomas

Who this might be right for
Glioma
Central Hospital, Nancy, France 22
Testing effectiveness (Phase 2)Active Not RecruitingNCT04458272
What this trial is testing

DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma

Who this might be right for
WHO Grade II Glioma
Daiichi Sankyo Co., Ltd. 25
Large-scale testing (Phase 3)Looking for participantsNCT06387069
What this trial is testing

Evaluate HMPL-306 in Patients With IDH1or IDH2-mutated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia
Hutchmed 316
Not applicableUnknownNCT04369287
What this trial is testing

Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaIDH1 Gene MutationIDH2 Gene Mutation
Istituto Clinico Humanitas 654
Testing effectiveness (Phase 2)WithdrawnNCT02977689
What this trial is testing

Trial of IDH305 in IDH1 Mutant Grade II or III Glioma

Who this might be right for
Glioma
NYU Langone Health
Not applicableUnknownNCT04908267
What this trial is testing

How the Precise Habitats Can Predict the IDH Mutation Status and Prognosis of the Patients With High-grade Gliomas

Who this might be right for
High-grade Glioma
Weiguo Zhang 100
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