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Results for “IDH-mutant Gliomas”

51 trials

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Showing 20 of 51 results

Testing effectiveness (Phase 2)Looking for participantsNCT05765812
What this trial is testing

Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA 116
Early research (Phase 1)Looking for participantsNCT06860594
What this trial is testing

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

Who this might be right for
Astrocytoma, IDH-Mutant, Grade 2Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-MutantRecurrent Adult Diffuse Midline Glioma, H3 K27-Mutant+4 more
National Cancer Institute (NCI) 30
Not applicableLooking for participantsNCT06623565
What this trial is testing

Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques

Who this might be right for
GlioblastomaAstrocytoma, IDH-Mutant, Grade 4
Amsterdam UMC, location VUmc 30
Not applicableLooking for participantsNCT04975139
What this trial is testing

Cognitive Changes of IDH-mutant and IDH-wildtype Glioma Patients After Chemoradiotherapy With Radiation Dose to the Resting State Networks

Who this might be right for
Glioma
Washington University School of Medicine 96
Early research (Phase 1)Active Not RecruitingNCT03749187
What this trial is testing

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Who this might be right for
GlioblastomaIDH1 Gene MutationIDH2 Gene Mutation+7 more
University of California, San Francisco 78
Testing effectiveness (Phase 2)Active Not RecruitingNCT03718767
What this trial is testing

Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

Who this might be right for
GliomaGlioblastomaHigh Grade Glioma+2 more
National Cancer Institute (NCI) 62
Testing effectiveness (Phase 2)Active Not RecruitingNCT04458272
What this trial is testing

DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma

Who this might be right for
WHO Grade II Glioma
Daiichi Sankyo Co., Ltd. 25
Large-scale testing (Phase 3)Active Not RecruitingNCT06105619
What this trial is testing

PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).

Who this might be right for
Glioblastoma
Beijing Pearl Biotechnology Limited Liability Company 84
Not applicableLooking for participantsNCT07374692
What this trial is testing

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

Who this might be right for
Recurrent CNS TumorsBrain CancerGliomas+3 more
National Cancer Institute (NCI) 80
Early research (Phase 1)Looking for participantsNCT05879367
What this trial is testing

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Who this might be right for
Glioblastoma, IDH-wildtypeGlioblastomaGlioblastoma Multiforme+4 more
Orbus Therapeutics, Inc. 66
Not applicableLooking for participantsNCT05190172
What this trial is testing

PRO-GLIO: PROton Versus Photon Therapy in IDH-mutated Diffuse Grade II and III GLIOmas

Who this might be right for
OligodendrogliomaOligodendroglioma, AnaplasticDiffuse Astrocytoma, IDH-Mutant
Oslo University Hospital 225
Large-scale testing (Phase 3)Active Not RecruitingNCT06780930
What this trial is testing

Phase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 orIDH2 Mutation

Who this might be right for
Residual or Recurrent Grade 2 IDH Mutant Glioma
Servier 57
Early research (Phase 1)Looking for participantsNCT06815029
What this trial is testing

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 3Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma
City of Hope Medical Center 27
Testing effectiveness (Phase 2)Looking for participantsNCT06047379
What this trial is testing

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Who this might be right for
Diffuse Astrocytoma, IDH-MutantGlioblastoma, IDH-wildtypeBrain Metastases, Adult+18 more
Neonc Technologies, Inc. 134
Early research (Phase 1)Looking for participantsNCT05789394
What this trial is testing

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

Who this might be right for
Recurrent Glioblastoma, IDH-WildtypeRecurrent Astrocytoma, IDH-Mutant, Grade 4Astrocytoma, Grade IV
Mayo Clinic 20
Early research (Phase 1)Looking for participantsNCT05609994
What this trial is testing

ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

Who this might be right for
Low Grade Glioma of Brain
Katy Peters, MD, PhD 48
Testing effectiveness (Phase 2)Ended earlyNCT05267106
What this trial is testing

Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations

Who this might be right for
GlioblastomaAdult-type Diffuse Gliomas
Incyte Corporation 83
Testing effectiveness (Phase 2)Active Not RecruitingNCT03180502
What this trial is testing

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Who this might be right for
Anaplastic AstrocytomaAnaplastic OligoastrocytomaAnaplastic Oligodendroglioma+5 more
NRG Oncology 120
Not applicableLooking for participantsNCT07240662
What this trial is testing

Vorasidenib in CNS WHO Grade 2 IDH-mutant Diffuse Glioma

Who this might be right for
Glioma
iOMEDICO AG 150
Early research (Phase 1)Study completedNCT04908176
What this trial is testing

A Drug-drug Interaction Study of Avapritinib and Midazolam

Who this might be right for
Gastrointestinal Stromal TumorsGISTNon-resectable Advanced Solid Tumors+1 more
Blueprint Medicines Corporation 10
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