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Results for “IDH-mutant Gliomas”

57 trials

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Showing 20 of 57 results

Testing effectiveness (Phase 2)Looking for participantsNCT05345002
What this trial is testing

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

Who this might be right for
GliomaIDH MutationAstrocytoma+1 more
Stephen Bagley, MD, MSCE 55
Early research (Phase 1)Looking for participantsNCT07544992
What this trial is testing

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma, IDH-Wildtype
City of Hope Medical Center 24
Early research (Phase 1)Looking for participantsNCT05609994
What this trial is testing

ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

Who this might be right for
Low Grade Glioma of Brain
Katy Peters, MD, PhD 48
Large-scale testing (Phase 3)Looking for participantsNCT06809322
What this trial is testing

Vorasidenib Maintenance for IDH Mutant Astrocytoma

Who this might be right for
IDH-mutant Grade 2 or 3 Astrocytoma
European Organisation for Research and Treatment of Cancer - EORTC 468
Early research (Phase 1)Looking for participantsNCT06815029
What this trial is testing

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

Who this might be right for
Recurrent Astrocytoma, IDH-Mutant, Grade 3Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma
City of Hope Medical Center 27
Testing effectiveness (Phase 2)Looking for participantsNCT07301268
What this trial is testing

GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

Who this might be right for
Glioblastoma, IDH-WildtypeProgressive Astrocytoma, IDH-Mutant, Grade 4Progressive Glioblastoma+6 more
Mayo Clinic 36
Very early researchLooking for participantsNCT06636162
What this trial is testing

Window of Opportunity Study of DSP-0390 in Gliomas

Who this might be right for
Glioma, MalignantIDH Mutation
Washington University School of Medicine 20
Not applicableLooking for participantsNCT07374692
What this trial is testing

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

Who this might be right for
Recurrent CNS TumorsBrain CancerGliomas+3 more
National Cancer Institute (NCI) 80
Not applicableLooking for participantsNCT06623565
What this trial is testing

Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques

Who this might be right for
GlioblastomaAstrocytoma, IDH-Mutant, Grade 4
Amsterdam UMC, location VUmc 30
Testing effectiveness (Phase 2)Looking for participantsNCT05765812
What this trial is testing

Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA 116
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Not applicableLooking for participantsNCT05190172
What this trial is testing

PRO-GLIO: PROton Versus Photon Therapy in IDH-mutated Diffuse Grade II and III GLIOmas

Who this might be right for
OligodendrogliomaOligodendroglioma, AnaplasticDiffuse Astrocytoma, IDH-Mutant
Oslo University Hospital 225
Early research (Phase 1)Enrolling By InvitationNCT06896110
What this trial is testing

Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma

Who this might be right for
Glioblastoma (GBM)Diffuse Midline Glioma (DMG)Astrocytoma, IDH-Mutant, Grade 4+2 more
Andrew P. Groves 34
Not applicableActive Not RecruitingNCT04975139
What this trial is testing

Cognitive Changes of IDH-mutant and IDH-wildtype Glioma Patients After Chemoradiotherapy With Radiation Dose to the Resting State Networks

Who this might be right for
Glioma
Washington University School of Medicine 71
Early research (Phase 1)Study completedNCT04908176
What this trial is testing

A Drug-drug Interaction Study of Avapritinib and Midazolam

Who this might be right for
Gastrointestinal Stromal TumorsGISTNon-resectable Advanced Solid Tumors+1 more
Blueprint Medicines Corporation 10
Not applicableStudy completedNCT05375318
What this trial is testing

BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels

Who this might be right for
Astrocytoma, Grade IVGlioblastomaGlioblastoma Multiforme+5 more
Juan M Garcia-Gomez 50
Not applicableNot Yet RecruitingNCT07469735
What this trial is testing

Vorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma

Who this might be right for
GliomaDiffuse GliomaRecurrent Gliomas
Huashan Hospital 10
Early research (Phase 1)Not Yet RecruitingNCT07629089
What this trial is testing

VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 Mutations

Who this might be right for
Brain Cancer
Megan Mantica 24
Testing effectiveness (Phase 2)Temporarily pausedNCT03952598
What this trial is testing

Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

Who this might be right for
GliomaGliomasHigh Grade Glioma+2 more
National Cancer Institute (NCI) 42
Testing effectiveness (Phase 2)Active Not RecruitingNCT03180502
What this trial is testing

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Who this might be right for
Anaplastic AstrocytomaAnaplastic OligoastrocytomaAnaplastic Oligodendroglioma+5 more
NRG Oncology 120
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