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Results for “IDH1 Mutation”

95 trials

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Showing 20 of 95 results

Large-scale testing (Phase 3)Active Not RecruitingNCT03173248
What this trial is testing

Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation

Who this might be right for
Newly Diagnosed Acute Myeloid Leukemia (AML)Untreated AMLAML Arising From Myelodysplastic Syndrome (MDS)+1 more
Institut de Recherches Internationales Servier 146
Testing effectiveness (Phase 2)Active Not RecruitingNCT06478212
What this trial is testing

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

Who this might be right for
IDH1-mutant GliomaIDH2-mutant Glioma
Institut de Recherches Internationales Servier 51
Testing effectiveness (Phase 2)Looking for participantsNCT04493164
What this trial is testing

CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Who this might be right for
Acute Myeloid Leukemia With Gene MutationsMyelodysplastic SyndromeMyeloproliferative Neoplasm+2 more
M.D. Anderson Cancer Center 30
Not applicableLooking for participantsNCT06607302
What this trial is testing

Ivosidenib in Locally Advanced or Metastatic Cholangiocarcinoma With IDH1 R132 Mutation After at Least One Prior Systemic Treatment - an Observational Study

Who this might be right for
Cholangiocarcinoma
iOMEDICO AG 100
Testing effectiveness (Phase 2)Study completedNCT03914742
What this trial is testing

BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations

Who this might be right for
IDH1 MutationIDH2 MutationRecurrent Glioblastoma+2 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 67
Testing effectiveness (Phase 2)Looking for participantsNCT06597734
What this trial is testing

Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm

Who this might be right for
Chronic Myelomonocytic LeukemiaAdvanced Myeloproliferative NeoplasmsIDH1-mutated Higher-Risk Myelodysplastic Syndromes
M.D. Anderson Cancer Center 45
Early research (Phase 1)Study completedNCT02073994
What this trial is testing

Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation

Who this might be right for
CholangiocarcinomaChondrosarcomaGlioma+1 more
Institut de Recherches Internationales Servier 174
Testing effectiveness (Phase 2)Ended earlyNCT03303950
What this trial is testing

Allogeneic Stem Cell Transplantation for Multiple Myeloma and Myelofibrosis

Who this might be right for
AnemiaASXL1 Gene MutationEZH2 Gene Mutation+7 more
University of Utah 6
Early research (Phase 1)Active Not RecruitingNCT03030066
What this trial is testing

Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas

Who this might be right for
Glioma
Daiichi Sankyo 47
Testing effectiveness (Phase 2)Active Not RecruitingNCT03212274
What this trial is testing

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

Who this might be right for
Advanced Malignant Solid NeoplasmGlioblastomaRecurrent Cholangiocarcinoma+4 more
National Cancer Institute (NCI) 89
Testing effectiveness (Phase 2)Looking for participantsNCT07282262
What this trial is testing

An Exploratory Study on the Use of Ivosidenib for the Precise Treatment of Advanced Biliary Tract Malignancies With IDH1 Mutations in the Later Line of Therapy.

Who this might be right for
Biliary Tract Cancer
Peking Union Medical College Hospital 300
Not applicableNot Yet RecruitingNCT07142226
What this trial is testing

Role of ctDNA in Genetic Profiling & Outcomes for Advanced BTC

Who this might be right for
Biliary Tract Cancer
CHA University 200
Early research (Phase 1)Looking for participantsNCT06543381
What this trial is testing

Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant

Who this might be right for
Acute Myeloid LeukemiaChronic Myelomonocytic LeukemiaMyelodysplastic Syndrome
City of Hope Medical Center 15
Early research (Phase 1)Looking for participantsNCT07025018
What this trial is testing

Phase I Study of HMPL-306 for the Treatment of Gliomas With IDH1 and/or IDH2 Mutations

Who this might be right for
Gliomas Harboring IDH1 and/or IDH2 Mutations
Hutchmed 52
Early research (Phase 1)Ended earlyNCT05814536
What this trial is testing

IDH1 Inhibitor AB-218 in Patients With Advanced IDH1 Mutant Cholangiocarcinoma and Other Solid Tumor

Who this might be right for
Cholangiocarcinoma With IDH1 MutationSolid Tumors With IDH1 Mutation
AnHeart Therapeutics Inc. 9
Early research (Phase 1)Active Not RecruitingNCT02632708
What this trial is testing

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

Who this might be right for
Newly Diagnosed Acute Myeloid Leukemia (AML)Untreated AMLAML Arising From Myelodysplastic Syndrome (MDS)+2 more
Institut de Recherches Internationales Servier 153
Large-scale testing (Phase 3)Looking for participantsNCT07075016
What this trial is testing

Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy

Who this might be right for
Acute Myeloid Leukemia
Stichting Hemato-Oncologie voor Volwassenen Nederland 227
Testing effectiveness (Phase 2)Looking for participantsNCT06707493
What this trial is testing

Ivosidenib as Post-HSCT Maintenance for AML

Who this might be right for
IDH1 MutationAcute Myeloid Leukemia (AML)Hematopoietic Stem Cell Transplant (HSCT)
Massachusetts General Hospital 75
Testing effectiveness (Phase 2)Looking for participantsNCT02704858
What this trial is testing

Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma

Who this might be right for
Glioblastoma Multiforme
Neonc Technologies, Inc. 49
Testing effectiveness (Phase 2)Looking for participantsNCT06668584
What this trial is testing

A Phase II Open-label Study of Olutasidenib Post-transplant Maintenance Therapy for Patients With IDH1-mutated Myeloid Malignancies

Who this might be right for
Myeloid Malignancies
M.D. Anderson Cancer Center 31
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