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Results for “Imetelstat”

40 trials

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Showing 20 of 40 results

Testing effectiveness (Phase 2)WithdrawnNCT02011126
What this trial is testing

Imetelstat Sodium in Treating Younger Patients With Relapsed or Refractory Solid Tumors

Who this might be right for
HepatoblastomaPreviously Treated Childhood RhabdomyosarcomaRecurrent Childhood Liver Cancer+5 more
Children's Oncology Group
Early research (Phase 1)Study completedNCT00861419
What this trial is testing

To Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 386 When Used in Combination With AMG 706, Bevacizumab, Sorafenib, or Sunitinib.

Who this might be right for
Advanced Solid Tumors
Amgen 88
Testing effectiveness (Phase 2)Ended earlyNCT00574951
What this trial is testing

AMG 706 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Who this might be right for
Fallopian Tube CancerOvarian CancerPrimary Peritoneal Cavity Cancer
Gynecologic Oncology Group 23
Testing effectiveness (Phase 2)Ended earlyNCT00356681
What this trial is testing

AMG 706 or Bevacizumab, in Combination With Paclitaxel Chemotherapy, as Treatment for Breast Cancer

Who this might be right for
Breast NeoplasmsBreast TumorsBreast Cancer+1 more
Amgen 282
Testing effectiveness (Phase 2)Ended earlyNCT01836549
What this trial is testing

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAstrocytoma, Grade II+6 more
Pediatric Brain Tumor Consortium 43
Early research (Phase 1)Active Not RecruitingNCT05371964
What this trial is testing

Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis

Who this might be right for
Myelofibrosis
Geron Corporation 30
Early research (Phase 1)Study completedNCT00322400
What this trial is testing

Phase1b to Evaluate Safety of AMG706 in Combination With Paclitaxel or Docetaxel for Breast Cancer

Who this might be right for
Locally Recurrent and Metastatic Breast Cancer
Amgen 46
Not applicableApproved For MarketingNCT05937568
What this trial is testing

Expanded Access for Treatment With Imetelstat

Who this might be right for
Myelodysplastic Syndromes
Geron Corporation
Early research (Phase 1)Ended earlyNCT00101907
What this trial is testing

Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of Patients With Advanced Cancer

Who this might be right for
Lung CancerPancreatic CancerEsophageal Cancer
Amgen 41
Testing effectiveness (Phase 2)WithdrawnNCT01349088
What this trial is testing

Investigational Drug in Combination With Two Chemotherapy Drugs in Women With Locally Recurrent or Metastatic Breast Cancer

Who this might be right for
Breast CancerMetastatic Breast CancerStage IV Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Early research (Phase 1)WithdrawnNCT01568632
What this trial is testing

Imetelstat for Children With Refractory or Recurrent Solid Tumors and Lymphoma

Who this might be right for
Solid TumorsLymphoma
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)Study completedNCT00089960
What this trial is testing

Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs)

Who this might be right for
Gastrointestinal Cancer
Amgen 138
Testing effectiveness (Phase 2)Study completedNCT00254267
What this trial is testing

Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors

Who this might be right for
Advanced Gastrointestinal Stromal Tumor
Amgen 35
Early research (Phase 1)Study completedNCT01386866
What this trial is testing

Single Dose Study of [14C]-Labelled AMG 706 in Patients With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Amgen 4
Testing effectiveness (Phase 2)Study completedNCT01137968
What this trial is testing

Imetelstat as Maintenance Therapy After Initial Induction Chemotherapy in Non-small Cell Lung Cancer (NSCLC)

Who this might be right for
Non-small Cell Lung Cancer
Geron Corporation 116
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07549451
What this trial is testing

Phase 2 Study Of Imetelstat for Patient With Myelodysplastic/Myeloproliferative Neoplasms

Who this might be right for
Phase IIImetelstatMyelodysplastic (MDS) / Myeloproliferative (MPN) Diseases
M.D. Anderson Cancer Center 30
Testing effectiveness (Phase 2)Study completedNCT01731951
What this trial is testing

Imetelstat Sodium in Treating Participants With Primary or Secondary Myelofibrosis

Who this might be right for
Primary MyelofibrosisSecondary MyelofibrosisMyeloid Malignancies
Geron Corporation 80
Early research (Phase 1)Study completedNCT00101894
What this trial is testing

Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer

Who this might be right for
Rectal CancerColon Cancer
Amgen 119
Testing effectiveness (Phase 2)Active Not RecruitingNCT05583552
What this trial is testing

Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy

Who this might be right for
Myelodysplastic SyndromesAcute Myeloid Leukemia
GCP-Service International West GmbH 46
Early research (Phase 1)Study completedNCT01235416
What this trial is testing

A Phase 1b, Open-label, Dose-finding Study of AMG 706 in Combination With Gemcitabine and Erlotinib to Treat Subjects With Solid Tumors

Who this might be right for
Histologically or Cytologically Documented Solid Tumors
Amgen 57
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