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Results for “Immune Checkpoint Blockade”

155 trials

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Showing 20 of 155 results

Testing effectiveness (Phase 2)Study completedNCT03548467
What this trial is testing

Evaluate Safety and Efficacy of Multiple Dosing With VB10.NEO and Bempegaldesleukin (NKTR-214) Immunotherapy in Patients With Locally Advanced or Metastatic Cancer

Who this might be right for
Locally Advanced or Metastatic Solid Tumours
Nykode Therapeutics ASA 41
Testing effectiveness (Phase 2)Looking for participantsNCT06630611
What this trial is testing

Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer (PragmaTIL)

Who this might be right for
MelanomaNon Small Cell Lung CancerCervical Cancer
Vall d'Hebron Institute of Oncology 40
Early research (Phase 1)WithdrawnNCT06290622
What this trial is testing

PD-1, LAG-3 and TIM-3 Checkpoint Blockade in DLBCL

Who this might be right for
Diffuse Large B Cell LymphomaLymphoma, B-CellLymphoma, Follicular
University of Alabama at Birmingham
Testing effectiveness (Phase 2)Study completedNCT03988036
What this trial is testing

A Study With Pembrolizumab in Combination With Dual Anti-HER2 Blockade With Trastuzumab and Pertuzumab in Early Breast Cancer Patients With Molecular HER2-enriched Intrinsic Subtype (Keyriched-1)

Who this might be right for
Breast Cancer
Women's Cancer Study Group GmbH 46
Testing effectiveness (Phase 2)WithdrawnNCT05456165
What this trial is testing

Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer

Who this might be right for
Colonic NeoplasmsColorectal Neoplasms
Gritstone bio, Inc.
Testing effectiveness (Phase 2)Active Not RecruitingNCT06250335
What this trial is testing

Impact of a Prebiotic Food-enriched Diet (PreFED) in Combination With Ipilimumab/Nivolumab Combination Immune Checkpoint Blockade (ICB) in ICB-refractory Melanoma Patients

Who this might be right for
ICB-refractory Melanoma
M.D. Anderson Cancer Center 4
Testing effectiveness (Phase 2)Ended earlyNCT06006923
What this trial is testing

Regorafenib in Combination With Pembrolizumab or Pembrolizumab for MSI-H Colorectal Cancer

Who this might be right for
MSI-H Colorectal Cancer
Anwaar Saeed 1
Testing effectiveness (Phase 2)Study completedNCT02821754
What this trial is testing

A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)

Who this might be right for
Biliary Tract NeoplasmsLiver CancerHepatocellular Carcinoma+2 more
National Cancer Institute (NCI) 54
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07011823
What this trial is testing

Immune-checkpoint Blockade After Partial Breast Irradiation by Pembrolizumab in Early TNBC

Who this might be right for
Triple-Negative Breast Neoplasm
Gangnam Severance Hospital 20
Testing effectiveness (Phase 2)WithdrawnNCT04648826
What this trial is testing

Aerosolized Azacytidine as Epigenetic Priming for Bintrafusp Alfa-Mediated Immune Checkpoint Blockade in Patients With Unresectable Pulmonary Metastases From Sarcomas, Germ Cell Tumors, or Epithelial Malignancies

Who this might be right for
SarcomasMelanomasGerm Cell Tumors+2 more
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)Looking for participantsNCT04273061
What this trial is testing

Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity

Who this might be right for
Breast CancerLung CancerGastrointestinal Cancer+6 more
British Columbia Cancer Agency 50
Large-scale testing (Phase 3)Active Not RecruitingNCT04907370
What this trial is testing

PD-1 Blockade Combined With De-intensified Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma

Who this might be right for
Nasopharyngeal Carcinoma
Sun Yat-sen University 532
Testing effectiveness (Phase 2)Study completedNCT04225390
What this trial is testing

Preconditioning of Tumor, Tumor Microenvironment and the Immune System to Immunotherapy

Who this might be right for
Immunotherapy
University of Erlangen-Nürnberg Medical School 38
Testing effectiveness (Phase 2)Study completedNCT04577807
What this trial is testing

LUMINOS-102: Lerapolturev With or Without Immune Checkpoint Blockade in Advanced PD-1 Refractory Melanoma

Who this might be right for
Melanoma
Istari Oncology, Inc. 27
Testing effectiveness (Phase 2)Ended earlyNCT04638582
What this trial is testing

Pembrolizumab as Neoadjuvant Therapy for Resectable Stage IA3 to IIA Non-Small Cell Lung Cancer (NSCLC)

Who this might be right for
Lung Cancer, Nonsmall Cell
McGill University Health Centre/Research Institute of the McGill University Health Centre 6
Testing effectiveness (Phase 2)Study completedNCT02601014
What this trial is testing

Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7

Who this might be right for
Prostate CancerRecurrent Prostate CarcinomaStage IV Prostate Adenocarcinoma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 32
Not applicableUnknownNCT04507750
What this trial is testing

Camrelizumab Combined With Apatinib in the Treatment of Epithelial Ovarian Cancer

Who this might be right for
Immune Checkpoint Inhibition
Qianfoshan Hospital 40
Testing effectiveness (Phase 2)Ended earlyNCT03233724
What this trial is testing

Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas

Who this might be right for
Carcinoma, Non-Small-Cell LungLung CancerNon-Small Cell Lung Cancer+2 more
National Cancer Institute (NCI) 9
Testing effectiveness (Phase 2)Looking for participantsNCT05533697
What this trial is testing

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
ModernaTX, Inc. 361
Testing effectiveness (Phase 2)Study completedNCT04045613
What this trial is testing

Derazantinib and Atezolizumab in Patients With Urothelial Cancer

Who this might be right for
Urothelial Carcinoma
Basilea Pharmaceutica 95
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