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Results for “Isocitrate Dehydrogenase”

53 trials

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Showing 20 of 53 results

Early research (Phase 1)Looking for participantsNCT07755397
What this trial is testing

First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands Tumor

Who this might be right for
NSCLC Patients With EGFR Activating MutationAdenoid Cystic Carcinoma MetastaticAdenoid Cystic Carcinoma of the Head and Neck
Jubilant Therapeutics India Limited 30
Testing effectiveness (Phase 2)Study completedNCT01915498
What this trial is testing

Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutation

Who this might be right for
Hematologic Neoplasms
Celgene 345
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07703436
What this trial is testing

Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease

Who this might be right for
Grade 2 IDH1-mutant GliomaGrade 3 IDH1-mutant GliomaGlioma+5 more
Nuvation Bio Inc. 40
Early research (Phase 1)Active Not RecruitingNCT03749187
What this trial is testing

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Who this might be right for
GlioblastomaIDH1 Gene MutationIDH2 Gene Mutation+7 more
University of California, San Francisco 78
Not applicableActive Not RecruitingNCT06969352
What this trial is testing

A Multicentre, Retrospective-prospective Real-world Study: to Evaluate the Effectiveness and Safety of Vorasidenib in Patients With Isocitrate Dehydrogenase IDH1/2 Mutant Grade 2 Astrocytoma or Oligodendroglioma (VICTORIA Study)

Who this might be right for
Gliomas
Servier (Tianjin) Pharmaceutical Co. LTD. 62
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06258018
What this trial is testing

Niraparib and Temozolomide in Patients Glioblastoma

Who this might be right for
Glioma, Malignant
Armando Santoro, MD 86
Early research (Phase 1)Study completedNCT02071862
What this trial is testing

Study of the Glutaminase Inhibitor CB-839 in Solid Tumors

Who this might be right for
Solid TumorsTriple-Negative Breast CancerNon Small Cell Lung Cancer+7 more
Calithera Biosciences, Inc 210
Not applicableLooking for participantsNCT07111195
What this trial is testing

Feasibility of ONCOhabitats for Surgical and Treatment Planning in IDH-Wildtype Glioblastoma (SINUE)

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
Juan M Garcia-Gomez 140
Early research (Phase 1)Ended earlyNCT04762602
What this trial is testing

HMPL-306 in Advanced Solid Tumors With IDH Mutations

Who this might be right for
Isocitrate Dehydrogenase Gene Mutation
Hutchmed 42
Testing effectiveness (Phase 2)Active Not RecruitingNCT03878095
What this trial is testing

Testing Olaparib and AZD6738 in IDH1 and IDH2 Mutant Tumors

Who this might be right for
Malignant Solid NeoplasmRefractory CholangiocarcinomaRefractory Malignant Solid Neoplasm
National Cancer Institute (NCI) 24
Testing effectiveness (Phase 2)Study completedNCT03779230
What this trial is testing

Safety and Efficacy of L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse

Who this might be right for
Glioma of Brain
Philogen S.p.A. 20
Early research (Phase 1)Study completedNCT02283190
What this trial is testing

1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML)

Who this might be right for
Acute Myeloid Leukemia
Ashkan Emadi 5
Early research (Phase 1)Study completedNCT06671873
What this trial is testing

Study on Mass Balance of [14C]HMPL-306（Isocitrate Dehydrogenase Inhibitor） in Healthy Chinese Adult Male Subjects

Who this might be right for
Mass Balance Study
Hutchmed 6
Not applicableLooking for participantsNCT07159607
What this trial is testing

Amino Acid PET-based Response Assessment in IDH-mutant Gliomas (APPEAR)

Who this might be right for
IDH-mutant Glioma (Oligodendroglioma, Astrocytoma)
LMU Klinikum 100
Testing effectiveness (Phase 2)Looking for participantsNCT07185880
What this trial is testing

The Safety and Tolerability of MT-125 in GBM Patients

Who this might be right for
Glioblastoma (GBM)
Myosin Therapeutics Inc. 36
Testing effectiveness (Phase 2)Active Not RecruitingNCT03953898
What this trial is testing

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAcute Myeloid Leukemia Post Cytotoxic Therapy+4 more
National Cancer Institute (NCI) 14
Testing effectiveness (Phase 2)Looking for participantsNCT05765812
What this trial is testing

Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA 116
Early research (Phase 1)Looking for participantsNCT05879367
What this trial is testing

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Who this might be right for
Glioblastoma, IDH-wildtypeGlioblastomaGlioblastoma Multiforme+4 more
Orbus Therapeutics, Inc. 66
Not applicableLooking for participantsNCT05700071
What this trial is testing

MRS of Glioma Genomics

Who this might be right for
Glioma
Institut National de la Santé Et de la Recherche Médicale, France 110
Not applicableNot Yet RecruitingNCT07788430
What this trial is testing

Impact of Pesticide Exposure on Survival and Tumor Aggressiveness in Patients With Glioblastoma: A Prospective Clinical Study

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
Institut Claudius Regaud 120
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