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Results for “Isocitrate Dehydrogenase”

43 trials

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Showing 20 of 43 results

Testing effectiveness (Phase 2)Looking for participantsNCT05765812
What this trial is testing

Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA 116
Early research (Phase 1)Active Not RecruitingNCT04603001
What this trial is testing

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+1 more
Eli Lilly and Company 260
Testing effectiveness (Phase 2)Active Not RecruitingNCT02677922
What this trial is testing

Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Who this might be right for
Leukemia, Myeloid, Acute
Celgene 130
Early research (Phase 1)Active Not RecruitingNCT03749187
What this trial is testing

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Who this might be right for
GlioblastomaIDH1 Gene MutationIDH2 Gene Mutation+7 more
University of California, San Francisco 78
Large-scale testing (Phase 3)Not Yet RecruitingNCT05987358
What this trial is testing

A Clinical Study of TQB3454 Tablets in the Treatment of Advanced Biliary Carcinoma.

Who this might be right for
Biliary Carcinoma
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 165
Early research (Phase 1)Looking for participantsNCT05879367
What this trial is testing

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Who this might be right for
Glioblastoma, IDH-wildtypeGlioblastomaGlioblastoma Multiforme+4 more
Orbus Therapeutics, Inc. 66
Not applicableActive Not RecruitingNCT05969691
What this trial is testing

Radiomics-Based Visualization and Quantitative Validation of IDH1 Heterogeneity in Gliomas

Who this might be right for
Glioma, MalignantComputer-Assisted
Mingge LLC 18
Early research (Phase 1)Study completedNCT06671873
What this trial is testing

Study on Mass Balance of [14C]HMPL-306（Isocitrate Dehydrogenase Inhibitor） in Healthy Chinese Adult Male Subjects

Who this might be right for
Mass Balance Study
Hutchmed 6
Testing effectiveness (Phase 2)Active Not RecruitingNCT03953898
What this trial is testing

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAcute Myeloid Leukemia Post Cytotoxic Therapy+4 more
National Cancer Institute (NCI) 14
Testing effectiveness (Phase 2)WithdrawnNCT04737174
What this trial is testing

ES-481 for Uncontrolled Glioma-Associated Epilepsy and Assessment for Potential Anti-Tumorigenic Effect in Patients With Isocitrate Dehydrogenase 1 (IDH1) Mutant Tumors

Who this might be right for
Epilepsy; Seizure
ES Therapeutics Australia Pty Ltd
Not applicableNot Yet RecruitingNCT06969352
What this trial is testing

A Multicentre, Retrospective-prospective Real-world Study: to Evaluate the Effectiveness and Safety of Vorasidenib in Patients With Isocitrate Dehydrogenase IDH1/2 Mutant Grade 2 Astrocytoma or Oligodendroglioma (VICTORIA Study)

Who this might be right for
Gliomas
Servier (Tianjin) Pharmaceutical Co. LTD. 60
Not applicableLooking for participantsNCT05700071
What this trial is testing

MRS of Glioma Genomics

Who this might be right for
Glioma
Institut National de la Santé Et de la Recherche Médicale, France 80
Testing effectiveness (Phase 2)Ended earlyNCT05267106
What this trial is testing

Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations

Who this might be right for
GlioblastomaAdult-type Diffuse Gliomas
Incyte Corporation 83
Large-scale testing (Phase 3)Study completedNCT02577406
What this trial is testing

An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation

Who this might be right for
Leukemia, MyeloidIsocitrate Dehydrogenase
Celgene 319
Early research (Phase 1)Study completedNCT02283190
What this trial is testing

1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML)

Who this might be right for
Acute Myeloid Leukemia
Ashkan Emadi 5
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07386002
What this trial is testing

The GLIOMAX Study: MT027 Allogeneic CAR-T for Recurrent Glioma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
T-MAXIMUM Pharmaceutical Inc 40
Not applicableUnknownNCT03102112
What this trial is testing

Noninvasively Predicting Gene Status of Glioma

Who this might be right for
Glioma of Brain
Tang-Du Hospital 50
Not applicableLooking for participantsNCT07111195
What this trial is testing

Feasibility of ONCOhabitats for Surgical and Treatment Planning in IDH-Wildtype Glioblastoma (SINUE)

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
Juan M Garcia-Gomez 140
Very early researchLooking for participantsNCT06552260
What this trial is testing

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

Who this might be right for
GlioblastomaRecurrent GlioblastomaBrain Tumor
Ugonma Chukwueke 27
Not applicableStudy completedNCT05375318
What this trial is testing

BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels

Who this might be right for
Astrocytoma, Grade IVGlioblastomaGlioblastoma Multiforme+5 more
Juan M Garcia-Gomez 50
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