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Results for “Isocitrate Dehydrogenase”

48 trials

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Showing 20 of 48 results

Early research (Phase 1)Study completedNCT06671873
What this trial is testing

Study on Mass Balance of [14C]HMPL-306（Isocitrate Dehydrogenase Inhibitor） in Healthy Chinese Adult Male Subjects

Who this might be right for
Mass Balance Study
Hutchmed 6
Testing effectiveness (Phase 2)WithdrawnNCT04737174
What this trial is testing

ES-481 for Uncontrolled Glioma-Associated Epilepsy and Assessment for Potential Anti-Tumorigenic Effect in Patients With Isocitrate Dehydrogenase 1 (IDH1) Mutant Tumors

Who this might be right for
Epilepsy; Seizure
ES Therapeutics Australia Pty Ltd
Testing effectiveness (Phase 2)Looking for participantsNCT05864534
What this trial is testing

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Who this might be right for
Newly Diagnosed GlioblastomaGlioblastoma, Isocitric Dehydrogenase (IDH)-WildtypeGliosarcoma+1 more
Northwestern University 25
Early research (Phase 1)Ended earlyNCT04782609
What this trial is testing

Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma

Who this might be right for
Recurrent Glioblastoma Multiforme (GBM)Grade 3 Isocitrate Dehydrogenase (IDH) Wildtype AstrocytomaGrade 3 or 4 Astrocytoma+1 more
Samus Therapeutics, Inc. 7
Testing effectiveness (Phase 2)Temporarily pausedNCT04677049
What this trial is testing

Study of Niacin in Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
AHS Cancer Control Alberta 59
Testing effectiveness (Phase 2)Looking for participantsNCT07185880
What this trial is testing

The Safety and Tolerability of MT-125 in GBM Patients

Who this might be right for
Glioblastoma (GBM)
Myosin Therapeutics Inc. 36
Testing effectiveness (Phase 2)Study completedNCT03779230
What this trial is testing

Safety and Efficacy of L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse

Who this might be right for
Glioma of Brain
Philogen S.p.A. 20
Testing effectiveness (Phase 2)Looking for participantsNCT06717958
What this trial is testing

Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation

Who this might be right for
AMLMDS
Technische Universität Dresden 76
Very early researchEnrolling By InvitationNCT07520214
What this trial is testing

Clinical Study on the Safety and Immunogenicity of Specific Cancer Vaccines in Preventing Recurrence of Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeGlioblastom WHO Grade 4
Beijing Neurosurgical Institute 9
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07604285
What this trial is testing

Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated Glioblastoma

Who this might be right for
Glioblastoma
Myosin Therapeutics Inc. 36
Testing effectiveness (Phase 2)Looking for participantsNCT05765812
What this trial is testing

Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA 116
Large-scale testing (Phase 3)Study completedNCT02577406
What this trial is testing

An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation

Who this might be right for
Leukemia, MyeloidIsocitrate Dehydrogenase
Celgene 319
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07620548
What this trial is testing

Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent Glioblastomas

Who this might be right for
GlioblastomaGlioblastoma, IDH-wildtypeGlioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
Washington University School of Medicine 99
Not applicableLooking for participantsNCT06430424
What this trial is testing

Study of Metabolic, Transcriptomic and Proteomic Characteristics in Relapsed Glioblastoma

Who this might be right for
Relapsed CancerGlioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
University Hospital, Bordeaux 40
Not applicableLooking for participantsNCT07111195
What this trial is testing

Feasibility of ONCOhabitats for Surgical and Treatment Planning in IDH-Wildtype Glioblastoma (SINUE)

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype
Juan M Garcia-Gomez 140
Not applicableLooking for participantsNCT05700071
What this trial is testing

MRS of Glioma Genomics

Who this might be right for
Glioma
Institut National de la Santé Et de la Recherche Médicale, France 80
Very early researchLooking for participantsNCT06552260
What this trial is testing

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

Who this might be right for
GlioblastomaRecurrent GlioblastomaBrain Tumor
Ugonma Chukwueke 27
Not applicableStudy completedNCT05375318
What this trial is testing

BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels

Who this might be right for
Astrocytoma, Grade IVGlioblastomaGlioblastoma Multiforme+5 more
Juan M Garcia-Gomez 50
Early research (Phase 1)Not Yet RecruitingNCT07629089
What this trial is testing

VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 Mutations

Who this might be right for
Brain Cancer
Megan Mantica 24
Early research (Phase 1)Active Not RecruitingNCT04603001
What this trial is testing

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+1 more
Eli Lilly and Company 260
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