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Results for “Isocitrate Dehydrogenase Gene Mutation”

16 trials

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Showing 16 of 16 results

Early research (Phase 1)Ended earlyNCT04764474
What this trial is testing

HMPL-306 in Advanced Hematological Malignancies With mIDH

Who this might be right for
Isocitrate Dehydrogenase Gene Mutation
Hutchmed 46
Large-scale testing (Phase 3)Active Not RecruitingNCT05987358
What this trial is testing

A Clinical Study of TQB3454 Tablets in the Treatment of Advanced Biliary Carcinoma.

Who this might be right for
Biliary Carcinoma
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 165
Testing effectiveness (Phase 2)Active Not RecruitingNCT03953898
What this trial is testing

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAcute Myeloid Leukemia Post Cytotoxic Therapy+4 more
National Cancer Institute (NCI) 14
Testing effectiveness (Phase 2)Looking for participantsNCT05588141
What this trial is testing

A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Who this might be right for
Brain TumorCancer
National Cancer Institute (NCI) 96
Early research (Phase 1)Looking for participantsNCT07755397
What this trial is testing

First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands Tumor

Who this might be right for
NSCLC Patients With EGFR Activating MutationAdenoid Cystic Carcinoma MetastaticAdenoid Cystic Carcinoma of the Head and Neck
Jubilant Therapeutics India Limited 30
Large-scale testing (Phase 3)Study completedNCT02577406
What this trial is testing

An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation

Who this might be right for
Leukemia, MyeloidIsocitrate Dehydrogenase
Celgene 319
Testing effectiveness (Phase 2)Study completedNCT02496741
What this trial is testing

Metformin And Chloroquine in IDH1/2-mutated Solid Tumors

Who this might be right for
GliomaCholangiocarcinomaChondrosarcoma
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 15
Early research (Phase 1)Ended earlyNCT04762602
What this trial is testing

HMPL-306 in Advanced Solid Tumors With IDH Mutations

Who this might be right for
Isocitrate Dehydrogenase Gene Mutation
Hutchmed 42
Early research (Phase 1)Study completedNCT02071862
What this trial is testing

Study of the Glutaminase Inhibitor CB-839 in Solid Tumors

Who this might be right for
Solid TumorsTriple-Negative Breast CancerNon Small Cell Lung Cancer+7 more
Calithera Biosciences, Inc 210
Testing effectiveness (Phase 2)Active Not RecruitingNCT02677922
What this trial is testing

Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Who this might be right for
Leukemia, Myeloid, Acute
Celgene 130
Testing effectiveness (Phase 2)Looking for participantsNCT06717958
What this trial is testing

Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation

Who this might be right for
AMLMDS
Technische Universität Dresden 76
Testing effectiveness (Phase 2)Study completedNCT01915498
What this trial is testing

Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutation

Who this might be right for
Hematologic Neoplasms
Celgene 345
Very early researchStudy completedNCT05851378
What this trial is testing

Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma

Who this might be right for
Adult Gliomas, Mixed
Robert Bok, MD, PhD 13
Early research (Phase 1)Active Not RecruitingNCT03749187
What this trial is testing

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Who this might be right for
GlioblastomaIDH1 Gene MutationIDH2 Gene Mutation+7 more
University of California, San Francisco 78
Testing effectiveness (Phase 2)WithdrawnNCT02977689
What this trial is testing

Trial of IDH305 in IDH1 Mutant Grade II or III Glioma

Who this might be right for
Glioma
NYU Langone Health
Large-scale testing (Phase 3)Not Yet RecruitingNCT07712757
What this trial is testing

Safety and Efficacy Study of Safusidenib in Participants With Grade 2 IDH1-Mutant Glioma

Who this might be right for
Grade 2 Glioma (Astrocytoma or Oligodendroglioma) With an IDH1 MutationAstrocytoma IDH Mutant Grade 2Oligodendroglioma+2 more
Nuvation Bio Inc. 140