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Results for “Ivosidenib”

52 trials

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Showing 20 of 52 results

Large-scale testing (Phase 3)Active Not RecruitingNCT03839771
What this trial is testing

Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic Syndrome With Excess Blasts-2
Stichting Hemato-Oncologie voor Volwassenen Nederland 968
Testing effectiveness (Phase 2)Looking for participantsNCT07007949
What this trial is testing

A New Treatment of Newly Diagnosed IDH1 Mutation Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaIDH1 Gene MutationIvosidenib
The First Affiliated Hospital of Soochow University 42
Early research (Phase 1)Active Not RecruitingNCT04603001
What this trial is testing

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+1 more
Eli Lilly and Company 260
Testing effectiveness (Phase 2)Active Not RecruitingNCT05030441
What this trial is testing

Ivosidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH1

Who this might be right for
Clonal Cytopenia of Undetermined Significance
Washington University School of Medicine 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT02677922
What this trial is testing

Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Who this might be right for
Leukemia, Myeloid, Acute
Celgene 130
Early research (Phase 1)Looking for participantsNCT05010772
What this trial is testing

Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or Ivosidenib as Maintenance Therapy for the Treatment of Acute Myeloid Leukemia in Remission

Who this might be right for
Acute Myeloid Leukemia
M.D. Anderson Cancer Center 125
Large-scale testing (Phase 3)Looking for participantsNCT06465953
What this trial is testing

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

Who this might be right for
Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)Myelodysplastic Syndromes (MDS)
Institut de Recherches Internationales Servier 48
Testing effectiveness (Phase 2)Active Not RecruitingNCT04195555
What this trial is testing

Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

Who this might be right for
Recurrent EpendymomaRecurrent Ewing SarcomaRecurrent Hepatoblastoma+30 more
National Cancer Institute (NCI) 3
Not applicableLooking for participantsNCT06377579
What this trial is testing

OBServatory of Compassionate Use of IVOsidenib in France for Patients With Acute Myeloid Leukemia

Who this might be right for
AML, Adult
French Innovative Leukemia Organisation 250
Early research (Phase 1)Study completedNCT03343197
What this trial is testing

Study of AG-120 and AG-881 in Subjects With Low Grade Glioma

Who this might be right for
Glioma
Institut de Recherches Internationales Servier 49
Testing effectiveness (Phase 2)Looking for participantsNCT03471260
What this trial is testing

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

Who this might be right for
Acute Myeloid LeukemiaHematopoietic and Lymphoid System NeoplasmMyelodysplastic Syndrome+3 more
M.D. Anderson Cancer Center 96
Not applicableApproved For MarketingNCT03245424
What this trial is testing

Ivosidenib Expanded Access Program in Relapsed/Refractory AML With an IDH1 Mutation

Who this might be right for
Acute Myeloid LeukemiaRelapsed Adult AMLRelapsed Pediatric AML
Agios Pharmaceuticals, Inc.
Early research (Phase 1)Study completedNCT02073994
What this trial is testing

Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation

Who this might be right for
CholangiocarcinomaChondrosarcomaGlioma+1 more
Institut de Recherches Internationales Servier 174
Testing effectiveness (Phase 2)Ended earlyNCT05921760
What this trial is testing

Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma

Who this might be right for
IDH1-mutant Cholangiocarcinoma
Servier Bio-Innovation LLC 7
Early research (Phase 1)Study completedNCT02831972
What this trial is testing

Drug-Drug Interaction Study of AG120 in Healthy Subjects

Who this might be right for
Healthy
Agios Pharmaceuticals, Inc. 22
Testing effectiveness (Phase 2)Active Not RecruitingNCT06081829
What this trial is testing

Ivosidenib in Previously Treated Japanese Subjects With Nonresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Who this might be right for
Cholangiocarcinoma Non-resectableCholangiocarcinoma Metastatic
Servier 12
Early research (Phase 1)Study completedNCT03282513
What this trial is testing

AG-120 (Ivosidenib) in Subjects With Mild or Moderate Hepatic Impairment or Normal Hepatic Function

Who this might be right for
Hepatic Impairment
Agios Pharmaceuticals, Inc. 33
Early research (Phase 1)Active Not RecruitingNCT04250051
What this trial is testing

Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or Refractory Acute Myeloid Leukemia

Who this might be right for
Recurrent Acute Myeloid LeukemiaRecurrent Myelodysplastic SyndromeRecurrent Myeloproliferative Neoplasm+2 more
Northwestern University 2
Testing effectiveness (Phase 2)Looking for participantsNCT07260175
What this trial is testing

Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma

Who this might be right for
CholangiocarcinomaIDH Mutation
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest 40
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06593548
What this trial is testing

Lvosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer

Who this might be right for
CRCMSSMetastatic Cancer
Fudan University 36
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