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Results for “KRAS G12C”

180 trials

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Showing 20 of 180 results

Not applicableLooking for participantsNCT06645236
What this trial is testing

DHF-20-1839-2: Clinical Performance Study Protocol for Therascreen® KRAS RGQ PCR Kit

Who this might be right for
Metastatic Colorectal Cancer (mCRC)
QIAGEN Gaithersburg, Inc 600
Testing effectiveness (Phase 2)Active Not RecruitingNCT05638295
What this trial is testing

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid Neoplasm
National Cancer Institute (NCI) 105
Testing effectiveness (Phase 2)Ended earlyNCT04933695
What this trial is testing

Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment

Who this might be right for
Non-small Cell Lung Cancer
Amgen 42
Early research (Phase 1)Ended earlyNCT05480865
What this trial is testing

SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation

Who this might be right for
Solid Tumor, AdultMetastatic Solid TumorMetastatic NSCLC+1 more
Navire Pharma Inc., a BridgeBio company 28
Early research (Phase 1)Looking for participantsNCT06720987
What this trial is testing

Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

Who this might be right for
KRAS G12C MutationKRAS G12S MutationSolid Tumor Malignancies+1 more
Kumquat Biosciences Inc. 140
Early research (Phase 1)Ended earlyNCT05497336
What this trial is testing

IBI351 in Combination With Cetuximab in Subjects With KRAS G12C Mutated Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Innovent Biologics (Suzhou) Co. Ltd. 8
Early research (Phase 1)Active Not RecruitingNCT04973163
What this trial is testing

Test Different Doses of BI 1823911 Alone and Combined With Other Medicines in People With Different Types of Advanced Cancer With KRAS Mutation

Who this might be right for
Solid Tumors, KRAS Mutation
Boehringer Ingelheim 30
Testing effectiveness (Phase 2)Study completedNCT05054725
What this trial is testing

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Who this might be right for
Non-Small Cell Lung Cancer
Revolution Medicines, Inc. 47
Not applicableApproved For MarketingNCT05162443
What this trial is testing

Expanded Access of Adagrasib (MRTX849) in Patients With Advanced Solid Tumors Who Have a KRAS G12C Mutation

Who this might be right for
Advanced CancerMetastatic CancerMalignant Neoplasm
Bristol-Myers Squibb
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07472478
What this trial is testing

Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12C-Mutant NSCLC (GIVEN Study)

Who this might be right for
Lung Cancer (NSCLC)KRAS G12C Lung Cancer
Guangdong Provincial People's Hospital 32
Large-scale testing (Phase 3)Looking for participantsNCT07190248
What this trial is testing

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 675
Early research (Phase 1)Looking for participantsNCT06804824
What this trial is testing

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Vividion Therapeutics, Inc. 220
Testing effectiveness (Phase 2)Looking for participantsNCT07012031
What this trial is testing

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Who this might be right for
Locally Advanced Lung Non-Small Cell CarcinomaMetastatic Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8+1 more
National Cancer Institute (NCI) 37
Early research (Phase 1)Looking for participantsNCT06659341
What this trial is testing

A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have Advanced Solid Cancers With Specific Genetic Changes Called KRASG12C Mutation

Who this might be right for
Advanced Solid Tumors Harboring KRAS G12C Mutation
Bayer 104
Testing effectiveness (Phase 2)Active Not RecruitingNCT05118854
What this trial is testing

A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation

Who this might be right for
Lung Cancer
M.D. Anderson Cancer Center 13
Large-scale testing (Phase 3)Active Not RecruitingNCT04793958
What this trial is testing

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Who this might be right for
Advanced Colorectal CancerMetastatic Colorectal Cancer
Mirati Therapeutics Inc. 461
Testing effectiveness (Phase 2)Looking for participantsNCT07164170
What this trial is testing

Clinical Study of Combination Therapy With ABSK043 and Glecirasib

Who this might be right for
Non-Small Cell Lung Cancer
Abbisko Therapeutics Co, Ltd 86
Early research (Phase 1)Not Yet RecruitingNCT07542704
What this trial is testing

Investigate the Safety and Efficacy of KQB368 as Monotherapy in Participants With Advanced Solid Malignancies

Who this might be right for
Advanced Solid TumorsColorectal Cancer (CRC)Non-Small Cell Lung Cancer+3 more
Kumquat Biosciences Inc. 48
Early research (Phase 1)Study completedNCT04959981
What this trial is testing

Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC

Who this might be right for
Advanced Non-squamous Non-small-cell Lung Cancer
Erasca, Inc. 24
Early research (Phase 1)Active Not RecruitingNCT05631899
What this trial is testing

CAR-DC Vaccine and ICIs in Local Advanced/Metastatic Solid Tumors

Who this might be right for
Solid Tumor, AdultEphA2 OverexpressionKRAS G12V+2 more
Chinese PLA General Hospital 9
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