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Results for “KRAS G12C Lung Cancer”

104 trials

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Showing 20 of 104 results

Testing effectiveness (Phase 2)UnknownNCT05451056
What this trial is testing

An Open-label, Phase 2trial of Sotorasib in KRAS G12C-mutant Non-small-cell Lung Cancer(NSCLC) Patients and a Translational Study to Find Acquired Resistance Mechanism to Sotorasib

Who this might be right for
Non Small Cell Lung Cancer
Yonsei University 37
Testing effectiveness (Phase 2)Study completedNCT04933695
What this trial is testing

Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment

Who this might be right for
Non-small Cell Lung Cancer
Amgen 42
Testing effectiveness (Phase 2)Looking for participantsNCT07252739
What this trial is testing

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

Who this might be right for
Malignant Neoplasm
Merck Sharp & Dohme LLC 130
Testing effectiveness (Phase 2)WithdrawnNCT05999357
What this trial is testing

JDQ443 for KRAS G12C NSCLC Brain Metastases

Who this might be right for
Non Small Cell Lung Cancer MetastaticBrain Metastases, AdultKRAS G12C
Maastricht University Medical Center
Not applicableNo Longer AvailableNCT04667234
What this trial is testing

Expanded Access of Sotorasib

Who this might be right for
Non Small-cell Lung CancerLocally Advanced Unresectable NSCLCLocally Advanced Metastatic NSCLC
Amgen
Testing effectiveness (Phase 2)Active Not RecruitingNCT04699188
What this trial is testing

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Who this might be right for
KRAS G12C Mutant Solid TumorsCarcinoma, Non-Small-Cell LungCarcinoma, Colorectal+7 more
Novartis Pharmaceuticals 344
Early research (Phase 1)Active Not RecruitingNCT06403436
What this trial is testing

A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorAdult Solid TumorAdult Disease+5 more
TOLREMO therapeutics AG 50
Early research (Phase 1)Looking for participantsNCT06026410
What this trial is testing

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

Who this might be right for
Solid Tumors With HRAS AlterationsNon Small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)+4 more
Kura Oncology, Inc. 300
Testing effectiveness (Phase 2)Looking for participantsNCT06582771
What this trial is testing

Sotorasib in People With Non-Small Cell Lung Cancer

Who this might be right for
Non Small Lung Cancer
Memorial Sloan Kettering Cancer Center 39
Testing effectiveness (Phase 2)Looking for participantsNCT07198841
What this trial is testing

IBI351 Plus Cetuximab β in Untreated Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

Who this might be right for
Lung Cancer (Non-Small Cell)
Guangdong Association of Clinical Trials 48
Large-scale testing (Phase 3)Looking for participantsNCT06890598
What this trial is testing

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company 700
Testing effectiveness (Phase 2)Looking for participantsNCT05786924
What this trial is testing

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Who this might be right for
Non-small Cell Lung CancerHistiocytic NeoplasmHistiocytosis+29 more
Institut de Recherches Internationales Servier 554
Early research (Phase 1)Ended earlyNCT06130254
What this trial is testing

Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers

Who this might be right for
Advanced Solid TumorNon-small Cell Lung Cancers
M.D. Anderson Cancer Center 1
Early research (Phase 1)Not Yet RecruitingNCT07542704
What this trial is testing

Investigate the Safety and Efficacy of KQB368 as Monotherapy in Participants With Advanced Solid Malignancies

Who this might be right for
Advanced Solid TumorsColorectal Cancer (CRC)Non-Small Cell Lung Cancer+3 more
Kumquat Biosciences Inc. 48
Early research (Phase 1)UnknownNCT06127940
What this trial is testing

K-SAB Trial - Sotorasib Followed by SBRT to 1-3 Lesions in Advanced NSCLC With KRASG12C Mutation

Who this might be right for
Non-small Cell Lung Cancer Metastatic
Karolinska University Hospital 20
Testing effectiveness (Phase 2)Study completedNCT06333678
What this trial is testing

A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC)

Who this might be right for
Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center 10
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07468071
What this trial is testing

Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

Who this might be right for
Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung CancerAdvanced Solid Tumors Harboring the KRAS G12C Mutation
Novartis Pharmaceuticals 40
Early research (Phase 1)Looking for participantsNCT06917079
What this trial is testing

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

Who this might be right for
Non-Small Cell Lung CancerNSCLCPDAC - Pancreatic Ductal Adenocarcinoma+11 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) 387
Early research (Phase 1)Active Not RecruitingNCT04449874
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Who this might be right for
Non-Small Cell Lung CancerColorectal CancerAdvanced Solid Tumors
Genentech, Inc. 498
Testing effectiveness (Phase 2)Ended earlyNCT05313009
What this trial is testing

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

Who this might be right for
Non-Small Cell Lung Cancer
Medical University of South Carolina 5
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