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Results for “KRAS G12C Mutations”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT05074810
What this trial is testing

Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients

Who this might be right for
Non Small Cell Lung CancerKRAS Activating Mutation
Verastem, Inc. 153
Testing effectiveness (Phase 2)Looking for participantsNCT07629960
What this trial is testing

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

Who this might be right for
Advanced Solid TumorNon-Small Cell Lung CancerColorectal Neoplasms+1 more
Blueprint Medicines Corporation 265
Testing effectiveness (Phase 2)Looking for participantsNCT06959615
What this trial is testing

A Phase I/IIa Study of JAB-23E73 in Patients With Advanced Solid Tumors Harboring KRAS Gene Alteration

Who this might be right for
Advanced Solid Tumor
Jacobio Pharmaceuticals Co., Ltd. 334
Testing effectiveness (Phase 2)UnknownNCT05993455
What this trial is testing

Basket Trial in Which Patients With Advanced Solid Tumors Carrying the KRAS G12C mUtation Receive Treatment With a Combination of Sotorasib and Panitumumab

Who this might be right for
Efficacy
Korea University Anam Hospital 24
Testing effectiveness (Phase 2)Looking for participantsNCT05276726
What this trial is testing

JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1

Who this might be right for
Non-small Cell Lung Cancer
Allist Pharmaceuticals, Inc. 104
Early research (Phase 1)Looking for participantsNCT05504278
What this trial is testing

Efficacy and Safety of IBI351 in Combination With Chemotherapy in Advanced Non-squamous Non-small Cell Lung Cancer Subjects With KRAS G12C Mutation

Who this might be right for
Advanced Non-Small Cell Lung Cancer
Innovent Biologics (Suzhou) Co. Ltd. 144
Testing effectiveness (Phase 2)Active Not RecruitingNCT04956640
What this trial is testing

Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)

Who this might be right for
Carcinoma, Non-Small-Cell LungColorectal NeoplasmsEndometrial Neoplasms+3 more
Eli Lilly and Company 540
Early research (Phase 1)Not Yet RecruitingNCT06594874
What this trial is testing

A Phase Ib Study of HS-10370 in Addition to Other Anti-cancer Therapies in Participants with KRAS G12C Mutation Advanced Solid Tumors

Who this might be right for
Non-Small Cell Lung CancerAdvanced Solid Tumors
Jiangsu Hansoh Pharmaceutical Co., Ltd. 350
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07814417
What this trial is testing

Olomorasib (LY3537982) in Participants With Advanced Colorectal Cancer and a KRAS G12C Mutation

Who this might be right for
Colorectal Neoplasms
Eli Lilly and Company 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT05194995
What this trial is testing

JAB-21822 in Combination With Cetuximab in Patients With Advanced CRC and Other Solid Tumors With KRAS G12C Mutation

Who this might be right for
Advanced Colorectal CancerSmall Intestinal CancerAppendiceal Cancer
Allist Pharmaceuticals, Inc. 48
Early research (Phase 1)Study completedNCT04967079
What this trial is testing

Trametinib Plus Anlotinib in Non-G12C KRAS-Mutant NSCLC Patients

Who this might be right for
Non Small Cell Lung Cancer
Shanghai Chest Hospital 33
Early research (Phase 1)Looking for participantsNCT06892054
What this trial is testing

Sotorasib Combined With First-line Chemotherapy for Advanced Pancreatic Adenocarcinoma

Who this might be right for
Pancreatic Adenocarcinoma
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) 15
Testing effectiveness (Phase 2)Looking for participantsNCT07492342
What this trial is testing

Fulzerasib Sequential Sintilimab Plus Platinum-Doublet Neoadjuvant Therapy for Resectable KRAS G12C-Mutant NSCLC

Who this might be right for
Resectable NSCLCKRAS G12C MutationStage IB-IIIA NSCLC+1 more
Jianxing He 30
Early research (Phase 1)Ended earlyNCT05840510
What this trial is testing

Adagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)

Who this might be right for
Solid Tumor, AdultNSCLCAdvanced Cancer+2 more
Mirati Therapeutics Inc. 6
Testing effectiveness (Phase 2)Enrolling By InvitationNCT06959589
What this trial is testing

The Efficacy and Safety of IBI351, Cetuximab β Combined With FOLFIRI as First-line /IBI351, Cetuximab β as Second-line in the Treatment of KRAS G12C-mutated Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticKRAS G12C Mutation
Second Affiliated Hospital, Zhejiang University, School of Medicine 50
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06936644
What this trial is testing

A Multicenter, Single-arm Phase II Study to Evaluate the Efficacy and Safety of Fulzerasib (IBI351) in Combination With Ivonescimab (AK-112) in First-line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer Patients With KRAS G12C Mutation

Who this might be right for
KRAS G12C Lung Cancer
Shanghai Chest Hospital 39
Testing effectiveness (Phase 2)Looking for participantsNCT06412198
What this trial is testing

Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations

Who this might be right for
Metastatic Colorectal CancerKRAS G12C Mutations
M.D. Anderson Cancer Center 31
Early research (Phase 1)WithdrawnNCT05848843
What this trial is testing

A Phase I Study of Adagrasib and Durvalumab for Treatment of Advanced Non-small Cell Lung Cancers and Gastro-intestinal Cancers Harboring KRAS G12C Mutations

Who this might be right for
Lung CancerGastro-intestinal Cancer
M.D. Anderson Cancer Center
Early research (Phase 1)Study completedNCT05178888
What this trial is testing

Adagrasib in Combination With Palbociclib in Patients With Advanced Solid Tumors (KRYSTAL-16)

Who this might be right for
Advanced Solid Tumor
Mirati Therapeutics Inc. 11
Large-scale testing (Phase 3)Active Not RecruitingNCT06497556
What this trial is testing

A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung CancerKRAS G12C Lung Cancer
Hoffmann-La Roche 338
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