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Results for “KRAS G12D”

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Testing effectiveness (Phase 2)Looking for participantsNCT07020221
What this trial is testing

VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Who this might be right for
Pancreatic Ductal AdenocarcinomaNon Small Cell Lung CancerColorectal Cancer+2 more
Verastem, Inc. 295
Early research (Phase 1)Looking for participantsNCT06040541
What this trial is testing

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)Pancreatic Ductal Adenocarcinoma (PDAC)+1 more
Revolution Medicines, Inc. 604
Testing effectiveness (Phase 2)WithdrawnNCT06690281
What this trial is testing

A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

Who this might be right for
Gastrointestinal CarcinomaPancreatic CancerHepatocellular Cancer+5 more
National Cancer Institute (NCI)
Large-scale testing (Phase 3)Looking for participantsNCT07566052
What this trial is testing

Compare Setidegrasib (ASP3082) With Docetaxel, in People With Non-small Cell Lung Cancer With a KRAS G12D Mutation

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)
Astellas Pharma Global Development, Inc. 356
Large-scale testing (Phase 3)Looking for participantsNCT07777822
What this trial is testing

Study of Pembrolizumab + Pemetrexed + Platinum Chemotherapy With or Without Zoldonrasib as First Line Treatment in Metastatic Non-squamous RAS G12D-Mutated NSCLC

Who this might be right for
NSCLCNon-small Cell Lung CancerNon-Small Cell Lung Cancer NSCLC+4 more
Revolution Medicines, Inc. 430
Testing effectiveness (Phase 2)Study completedNCT01833143
What this trial is testing

Bortezomib in KRAS-Mutant Non-Small Cell Lung Cancer in Never Smokers or Those With KRAS G12D

Who this might be right for
Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center 17
Large-scale testing (Phase 3)Looking for participantsNCT07232875
What this trial is testing

HRS 4642 Injection Combined With AG Versus Placebo Combined With AG Therapy in First-Line Advanced or Metastatic Pancreatic Cancer

Who this might be right for
KRAS G12D-Mutant Advanced or Metastatic Pancreatic Cancer in the First-line Setting
Jiangsu HengRui Medicine Co., Ltd. 588
Large-scale testing (Phase 3)Looking for participantsNCT07805954
What this trial is testing

Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma

Who this might be right for
Pancreatic CancerPancreatic Cancer MetastaticPDAC+5 more
Revolution Medicines, Inc. 400
Testing effectiveness (Phase 2)Looking for participantsNCT07629960
What this trial is testing

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

Who this might be right for
Advanced Solid TumorNon-Small Cell Lung CancerColorectal Neoplasms+1 more
Blueprint Medicines Corporation 265
Testing effectiveness (Phase 2)WithdrawnNCT07026916
What this trial is testing

A Phase II Study to Evaluate GFH375 in Patients With KRAS G12D Mutant Metastatic Pancreatic Cancer

Who this might be right for
Metastatic Pancreatic Cancer
Genfleet Therapeutics (Shanghai) Inc.
Early research (Phase 1)Looking for participantsNCT07094204
What this trial is testing

Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Who this might be right for
Solid TumorNon-Small-Cell Lung CancerPancreatic Ductal Adenocarcinoma+1 more
Astellas Pharma Inc 364
Large-scale testing (Phase 3)Looking for participantsNCT07621718
What this trial is testing

Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )

Who this might be right for
Pancreatic CancerPancreatic Cancer MetastaticPDAC+5 more
Revolution Medicines, Inc. 670
Early research (Phase 1)Looking for participantsNCT07535112
What this trial is testing

Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation

Who this might be right for
Advanced/Metastatic Colorectal Adenocarcinoma
Bayer 130
Early research (Phase 1)Study completedNCT04853017
What this trial is testing

ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors

Who this might be right for
Minimal Residual DiseaseKRAS G12DKRAS G12R+9 more
Elicio Therapeutics 25
Early research (Phase 1)Not Yet RecruitingNCT06963398
What this trial is testing

HS-10529 in KRAS G12D Patients With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Jiangsu Hansoh Pharmaceutical Co., Ltd. 520
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06949761
What this trial is testing

A Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of QLC1101 in Combination With Other Therapies in the Treatment of Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation

Who this might be right for
Solid Tumor
Qilu Pharmaceutical Co., Ltd. 240
Large-scale testing (Phase 3)Looking for participantsNCT07522073
What this trial is testing

Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

Who this might be right for
Solid Tumors
Incyte Corporation 588
Early research (Phase 1)Ended earlyNCT05737706
What this trial is testing

Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation

Who this might be right for
Solid TumorAdvanced Solid TumorNon-small Cell Lung Cancer+2 more
Mirati Therapeutics Inc. 63
Testing effectiveness (Phase 2)Looking for participantsNCT06445062
What this trial is testing

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Who this might be right for
Colorectal CancerCRCPancreatic Ductal Adenocarcinoma+3 more
Revolution Medicines, Inc. 1,130
Early research (Phase 1)Looking for participantsNCT07207707
What this trial is testing

Investigate the Safety and Efficacy of KQB548 in Participants With Advanced Solid Malignancies

Who this might be right for
Solid Tumor Malignancies
Kumquat Biosciences Inc. 78
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