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Results for “KRAS Mutant Non-Small Cell Lung Cancer”

79 trials

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Showing 20 of 79 results

Early research (Phase 1)Looking for participantsNCT07594067
What this trial is testing

TCR1188-ABC Cells in KRAS-mutated Cancers

Who this might be right for
CholangiocarcinomaColorectal CancerNon-Small Cell Lung Cancer+1 more
University of Pennsylvania 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06456138
What this trial is testing

Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC

Who this might be right for
KRAS Mutation-Related TumorsAdvanced Lung CancerRefractory Tumor
Shanghai Chest Hospital 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07472478
What this trial is testing

Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12C-Mutant NSCLC (GIVEN Study)

Who this might be right for
Lung Cancer (NSCLC)KRAS G12C Lung Cancer
Guangdong Provincial People's Hospital 32
Large-scale testing (Phase 3)Looking for participantsNCT07190248
What this trial is testing

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 675
Testing effectiveness (Phase 2)Ended earlyNCT03095612
What this trial is testing

Phase 1/2 Trial of Selinexor (KPT-330) With Docetaxel for Non-small Cell Lung Cancer (NSCLC)

Who this might be right for
Non-small Cell Lung Cancer
University of Texas Southwestern Medical Center 41
Early research (Phase 1)Looking for participantsNCT06040541
What this trial is testing

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)Pancreatic Ductal Adenocarcinoma (PDAC)+1 more
Revolution Medicines, Inc. 604
Early research (Phase 1)Ended earlyNCT04892017
What this trial is testing

Study of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid Tumors

Who this might be right for
Non-Small Cell Lung CancerAdvanced Solid TumorMetastatic Solid Tumor
Deciphera Pharmaceuticals, LLC 91
Testing effectiveness (Phase 2)Study completedNCT05002270
What this trial is testing

JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation

Who this might be right for
Advanced Solid TumorNSCLCCRC
Jacobio Pharmaceuticals Co., Ltd. 29
Testing effectiveness (Phase 2)Active Not RecruitingNCT04699188
What this trial is testing

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Who this might be right for
KRAS G12C Mutant Solid TumorsCarcinoma, Non-Small-Cell LungCarcinoma, Colorectal+7 more
Novartis Pharmaceuticals 344
Testing effectiveness (Phase 2)Ended earlyNCT06024174
What this trial is testing

BMS-986466 With Adagrasib With or Without Cetuximab in Participants With Kirsten Rat Sarcoma Virus Glycine 12 to Cysteine (KRAS G12C)-Mutant Solid Tumors

Who this might be right for
Advanced Solid Tumors
Bristol-Myers Squibb 5
Large-scale testing (Phase 3)Looking for participantsNCT06345729
What this trial is testing

Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 600
Large-scale testing (Phase 3)Looking for participantsNCT07554339
What this trial is testing

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 310
Early research (Phase 1)Study completedNCT03415126
What this trial is testing

ASN007 in Patients With Advanced Solid Tumors

Who this might be right for
CancerMalignancyNeoplasia+16 more
Asana BioSciences 49
Early research (Phase 1)Active Not RecruitingNCT05462717
What this trial is testing

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Who this might be right for
Non-Small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)Pancreatic Ductal Adenocarcinoma+1 more
Revolution Medicines, Inc. 222
Testing effectiveness (Phase 2)WithdrawnNCT05180422
What this trial is testing

A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis

Who this might be right for
Non Small Cell Lung Cancer
Criterium, Inc.
Early research (Phase 1)Ended earlyNCT01912625
What this trial is testing

Trametinib, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Who this might be right for
Recurrent Lung Non-Small Cell CarcinomaStage III Lung Non-Small Cell Cancer AJCC v7Stage IIIA Lung Non-Small Cell Cancer AJCC v7+1 more
National Cancer Institute (NCI) 16
Early research (Phase 1)Study completedNCT03299088
What this trial is testing

Pembrolizumab and Trametinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer and KRAS Gene Mutations

Who this might be right for
KRAS Gene MutationMetastatic Non-Squamous Non-Small Cell Lung CarcinomaRecurrent Non-Squamous Non-Small Cell Lung Carcinoma+1 more
Jonathan Riess 15
Testing effectiveness (Phase 2)Study completedNCT03704688
What this trial is testing

Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer

Who this might be right for
Non Small Cell Lung CancerKRAS Gene Mutation
Memorial Sloan Kettering Cancer Center 12
Testing effectiveness (Phase 2)Study completedNCT04735068
What this trial is testing

Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS Mutant Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung CancerKRAS Mutation-Related Tumors
Abramson Cancer Center at Penn Medicine 9
Early research (Phase 1)Ended earlyNCT05374538
What this trial is testing

VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
Vitrac Therapeutics, LLC 3
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