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Results for “KRAS-mutated”

331 trials

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Showing 20 of 331 results

Not applicableLooking for participantsNCT06645236
What this trial is testing

DHF-20-1839-2: Clinical Performance Study Protocol for Therascreen® KRAS RGQ PCR Kit

Who this might be right for
Metastatic Colorectal Cancer (mCRC)
QIAGEN Gaithersburg, Inc 600
Testing effectiveness (Phase 2)Temporarily pausedNCT05200442
What this trial is testing

VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer

Who this might be right for
Colorectal CancerColorectal AdenocarcinomaColorectal Cancer Metastatic+2 more
University of Chicago 53
Testing effectiveness (Phase 2)Ended earlyNCT04933695
What this trial is testing

Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment

Who this might be right for
Non-small Cell Lung Cancer
Amgen 42
Early research (Phase 1)Looking for participantsNCT07594067
What this trial is testing

TCR1188-ABC Cells in KRAS-mutated Cancers

Who this might be right for
CholangiocarcinomaColorectal CancerNon-Small Cell Lung Cancer+1 more
University of Pennsylvania 30
Not applicableActive Not RecruitingNCT05370469
What this trial is testing

Real-Time Monitoring of Symptoms in Lung Cancer Patients Receiving Oral Targeted Therapies

Who this might be right for
Lung CancerEGFR Gene MutationEGFR+6 more
University of Virginia 30
Not applicableStudy completedNCT03698253
What this trial is testing

Metastatic Colorectal Cancer Treated With Regorafenib and FOLFIRI

Who this might be right for
Colorectal Cancer
Kaohsiung Medical University Chung-Ho Memorial Hospital 41
Early research (Phase 1)Looking for participantsNCT06797336
What this trial is testing

PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

Who this might be right for
Solid Tumor
PAQ Therapeutics, Inc. 240
Early research (Phase 1)Study completedNCT02259114
What this trial is testing

A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)

Who this might be right for
NUT Midline CarcinomaTriple Negative Breast CancerNon-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation+3 more
Oncoethix GmbH, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 47
Early research (Phase 1)Ended earlyNCT05480865
What this trial is testing

SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation

Who this might be right for
Solid Tumor, AdultMetastatic Solid TumorMetastatic NSCLC+1 more
Navire Pharma Inc., a BridgeBio company 28
Early research (Phase 1)Looking for participantsNCT06720987
What this trial is testing

Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

Who this might be right for
KRAS G12C MutationKRAS G12S MutationSolid Tumor Malignancies+1 more
Kumquat Biosciences Inc. 140
Early research (Phase 1)Ended earlyNCT05497336
What this trial is testing

IBI351 in Combination With Cetuximab in Subjects With KRAS G12C Mutated Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Innovent Biologics (Suzhou) Co. Ltd. 8
Not applicableStudy completedNCT02352207
What this trial is testing

Risk Factors of Neonatal Respiratory Distress for Newborns With Prenatally Diagnosed Congenital Lung Malformations

Who this might be right for
Foetus With Congenital Pulmonary Malformation
Assistance Publique - Hôpitaux de Paris 436
Early research (Phase 1)Active Not RecruitingNCT04973163
What this trial is testing

Test Different Doses of BI 1823911 Alone and Combined With Other Medicines in People With Different Types of Advanced Cancer With KRAS Mutation

Who this might be right for
Solid Tumors, KRAS Mutation
Boehringer Ingelheim 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06456138
What this trial is testing

Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC

Who this might be right for
KRAS Mutation-Related TumorsAdvanced Lung CancerRefractory Tumor
Shanghai Chest Hospital 60
Not applicableLooking for participantsNCT05630989
What this trial is testing

A Registry to Capture Patient Outcomes With KRAS G12R Altered Advanced Pancreatic Ductal Adenocarcinoma Treated With MEK Inhibitor-based Combination Therapy

Who this might be right for
Pancreatic Ductal Adenocarcinoma
Mandana Kamgar, MD 80
Early research (Phase 1)Looking for participantsNCT06179160
What this trial is testing

Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

Who this might be right for
Solid Tumors
Incyte Corporation 710
Testing effectiveness (Phase 2)Study completedNCT05054725
What this trial is testing

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Who this might be right for
Non-Small Cell Lung Cancer
Revolution Medicines, Inc. 47
Not applicableApproved For MarketingNCT05162443
What this trial is testing

Expanded Access of Adagrasib (MRTX849) in Patients With Advanced Solid Tumors Who Have a KRAS G12C Mutation

Who this might be right for
Advanced CancerMetastatic CancerMalignant Neoplasm
Bristol-Myers Squibb
Not applicableLooking for participantsNCT06449989
What this trial is testing

Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticBrain Metastases, AdultRas (KRAS or NRAS) Gene Mutation+3 more
Blokhin's Russian Cancer Research Center 30
Not applicableActive Not RecruitingNCT07638878
What this trial is testing

The Efficacy of Tislelizumab Combined With Albumin-bound Paclitaxel and Platinum-based Chemotherapy in Patients With KRAS-mutated Lung Cancer

Who this might be right for
Lung Cancer (Locally Advanced or Metastatic)
Guangzhou Medical University 30
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