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Results for “LEPR Deficiency Obesity”

9 trials

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Showing 9 of 9 results

Large-scale testing (Phase 3)Study completedNCT04966741
What this trial is testing

Setmelanotide in Pediatric Participants With Rare Genetic Diseases of Obesity

Who this might be right for
Bardet-Biedl SyndromePOMC Deficiency ObesityPCSK1 Deficiency Obesity+1 more
Rhythm Pharmaceuticals, Inc. 12
Large-scale testing (Phase 3)Looking for participantsNCT07220772
What this trial is testing

A Study Evaluating Mibavademab Treatment of Obesity Due to Leptin (LEP) Gene Mutations in Children, Adolescents and Adults

Who this might be right for
Monogenic Obesity
Regeneron Pharmaceuticals 4
Large-scale testing (Phase 3)Active Not RecruitingNCT06548100
What this trial is testing

The Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)

Who this might be right for
Generalized Lipodystrophy
Regeneron Pharmaceuticals 9
Testing effectiveness (Phase 2)UnknownNCT06041841
What this trial is testing

Assess Efficacy and Safety of LB54640 in Patients With Genetic Obesity

Who this might be right for
POMC Deficiency ObesityPCSK1 Deficiency ObesityLEPR Deficiency Obesity
LG Chem 4
Not applicableAvailableNCT04710056
What this trial is testing

Expanded Access to REGN4461 for Patients With Diseases Associated With Deficient Leptin Signaling

Who this might be right for
LipodystrophyGeneralized Lipodystrophy (GLD)Monogenic Obesity (MOB)
Regeneron Pharmaceuticals
Testing effectiveness (Phase 2)Study completedNCT03013543
What this trial is testing

Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity

Who this might be right for
Genetic ObesityObesityObesity Due to Melanocortin 4 Receptor Deficiency
Rhythm Pharmaceuticals, Inc. 213
Large-scale testing (Phase 3)Study completedNCT03287960
What this trial is testing

Setmelanotide for the Treatment of Leptin Receptor (LEPR) Deficiency Obesity

Who this might be right for
Leptin Receptor Deficiency Obesity
Rhythm Pharmaceuticals, Inc. 15
Not applicableActive Not RecruitingNCT06239064
What this trial is testing

Early Genetic Identification of Obesity

Who this might be right for
Obesity, ChildhoodHyperphagiaRetinopathy+5 more
Rolfs Consulting und Verwaltungs-GmbH (RCV) 1,000
Not applicableStudy completedNCT03621007
What this trial is testing

An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes

Who this might be right for
POMC Deficiency ObesityPCSK1 Deficiency ObesityLEPR Deficiency Obesity
Rhythm Pharmaceuticals, Inc. 8