Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Leptomeningeal Metastases”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Not applicableNot Yet RecruitingNCT07659652
What this trial is testing

Quality of Life for Patients With Breast Cancer Brain Metastases and Leptomeningeal Disease

Who this might be right for
Breast Cancer, Quality of LifeBreast Cancer, MetastaticBreast Cancer, Metastatic Breast Cancer+2 more
University of California, San Francisco 200
Testing effectiveness (Phase 2)Study completedNCT02654106
What this trial is testing

Stereotactic Radiotherapy Plus Temozolomide for Refractory Brain Metastases

Who this might be right for
Brain Metastases
Chinese Academy of Medical Sciences 65
Early research (Phase 1)Active Not RecruitingNCT03423628
What this trial is testing

Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Who this might be right for
Recurrent Glioblastoma MultiformePrimary Glioblastoma MultiformeBrain Neoplasms, Malignant+1 more
AstraZeneca 159
Testing effectiveness (Phase 2)Looking for participantsNCT06809517
What this trial is testing

Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal MetastasisIntrathecal Drug Delivery
Guangzhou Medical University 34
Not applicableEnded earlyNCT05414123
What this trial is testing

A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide

Who this might be right for
Leptomeningeal MetastasisLeptomeningeal DiseaseLeptomeningeal Neoplasms+2 more
Biocept, Inc. 40
Early research (Phase 1)Ended earlyNCT00089245
What this trial is testing

Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer

Who this might be right for
Brain and Central Nervous System TumorsNeuroblastomaSarcoma
Y-mAbs Therapeutics 177
Not applicableUnknownNCT06410040
What this trial is testing

A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis

Who this might be right for
ALK-positive Non-small Cell Lung CancerBrain MetastasesMeningeal Metastasis
Sichuan Cancer Hospital and Research Institute 28
Testing effectiveness (Phase 2)Looking for participantsNCT06440954
What this trial is testing

Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases

Who this might be right for
Non-Small Cell Lung Cancer
Hunan Province Tumor Hospital 220
Early research (Phase 1)Not Yet RecruitingNCT07674693
What this trial is testing

Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastases
NYU Langone Health 29
Post-approval studies (Phase 4)UnknownNCT04356222
What this trial is testing

Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal MetastasisDurvalumab
Hui Bu 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07789912
What this trial is testing

BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies

Who this might be right for
Leptomeningeal MetastasisBreast CancerLung Cancer (NSCLC)
University of Miami 40
Testing effectiveness (Phase 2)Study completedNCT05146219
What this trial is testing

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

Who this might be right for
NSCLCEGFR Activating MutationBrain Metastases+1 more
TYK Medicines, Inc 29
Early research (Phase 1)Study completedNCT03101579
What this trial is testing

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

Who this might be right for
Leptomeningeal Metastases
The First Hospital of Jilin University 13
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07751744
What this trial is testing

Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma

Who this might be right for
Brain Metastases From Solid TumorsLeptomeningeal DiseaseHigh Grade Glioma (HGG)+1 more
Jubilant Therapeutics Inc. 113
Not applicableLooking for participantsNCT06638294
What this trial is testing

Study in Patients With Breast Cancer Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis of Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 30
Not applicableLooking for participantsNCT06643000
What this trial is testing

Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis

Who this might be right for
Non-small Cell Lung CancerLeptomeningeal MetastasisEGFR Gene Mutation
Henan Cancer Hospital 60
Testing effectiveness (Phase 2)Active Not RecruitingNCT04588545
What this trial is testing

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

Who this might be right for
HER2-positive Breast CancerLeptomeningeal MetastasisLeptomeningeal Disease
H. Lee Moffitt Cancer Center and Research Institute 33
Testing effectiveness (Phase 2)Study completedNCT02336451
What this trial is testing

A Phase II Study to Evaluate the Efficacy and Safety of Oral Ceritinib in Patients With ALK-positive NSCLC Metastatic to the Brain and/or to Leptomeninges

Who this might be right for
ALK-positive Non-small Cell Lung Cancer
Novartis Pharmaceuticals 156
Not applicableActive Not RecruitingNCT06984523
What this trial is testing

Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis
NYU Langone Health 20
Testing effectiveness (Phase 2)Ended earlyNCT00005812
What this trial is testing

Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

Who this might be right for
Brain TumorsCentral Nervous System TumorsLeptomeningeal Metastases
Dartmouth-Hitchcock Medical Center 12
Next Page