Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Leptomeningeal Neoplasms”

185 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 185 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT06537297
What this trial is testing

Intrathecal Pemetrexed Combined With High-dose Furmonertinib and Beva for EGFR-m NSCLC With Leptomeningeal Metastases

Who this might be right for
Non-small Cell Lung Cancer
Hunan Province Tumor Hospital 30
Early research (Phase 1)Not Yet RecruitingNCT07702305
What this trial is testing

Safety and Efficacy of Intrathecal Sacituzumab Tirumotecan for Leptomeningeal Metastasis in EGFR-TKI-Resistant Non-Small Cell Lung Cancer

Who this might be right for
EGFR-TKI-resistant Non-small Cell Lung Cancer With Leptomeningeal Metastasis
Henan Cancer Hospital 15
Not applicableLooking for participantsNCT04988009
What this trial is testing

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

Who this might be right for
Central Nervous System NeoplasmLeptomeningeal NeoplasmMetastatic Malignant Neoplasm in the Brain+1 more
M.D. Anderson Cancer Center 200
Early research (Phase 1)Study completedNCT00854867
What this trial is testing

Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis.

Who this might be right for
Solid Tumour Neoplastic MeningitisBrain Metastases
Mundipharma Research Limited 18
Not applicableLooking for participantsNCT06933199
What this trial is testing

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis

Who this might be right for
Brain Metastases
University Hospital Ostrava 260
Testing effectiveness (Phase 2)Study completedNCT06376292
What this trial is testing

A Prospective Single Arm Phase II Exploratory Study on the Combination of Whole Brain Radiotherapy, Thiotepa Intrathecal Injection and Systemic Treatment of Primary Diseases in the Treatment of Solid Tumor Leptomeningeal Metastasis

Who this might be right for
Solid Tumor Leptomeningeal Metastasis
Second Affiliated Hospital, Zhejiang University, School of Medicine 58
Early research (Phase 1)Study completedNCT00031928
What this trial is testing

Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors

Who this might be right for
Brain and Central Nervous System Tumors
National Cancer Institute (NCI) 3,000
Testing effectiveness (Phase 2)WithdrawnNCT04315246
What this trial is testing

177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma)

Who this might be right for
Leptomeningeal MetastasisSolid Tumor, Adult
Y-mAbs Therapeutics
Testing effectiveness (Phase 2)Looking for participantsNCT06901817
What this trial is testing

The Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Shanghai Cancer Hospital, China 97
Not applicableLooking for participantsNCT06417710
What this trial is testing

Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal MetastasisLeptomeningeal DiseaseLeptomeningeal Neoplasms+1 more
University of Zurich 200
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06861218
What this trial is testing

Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastases
Zhejiang Cancer Hospital 42
Early research (Phase 1)Active Not RecruitingNCT03696030
What this trial is testing

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Who this might be right for
Malignant NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges+2 more
City of Hope Medical Center 24
Not applicableLooking for participantsNCT05746754
What this trial is testing

Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis
University of Aarhus 50
Early research (Phase 1)Ended earlyNCT00515788
What this trial is testing

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Who this might be right for
Neoplastic Meningitis
M.D. Anderson Cancer Center 11
Testing effectiveness (Phase 2)UnknownNCT06339242
What this trial is testing

Furmonertinib Combined With Chemotherapy in the Treatment of NSCLC With Leptomeningeal Metastasis

Who this might be right for
NSCLC
Jiangsu Province Nanjing Brain Hospital 30
Post-approval studies (Phase 4)Study completedNCT00029523
What this trial is testing

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Who this might be right for
Meningeal Neoplasms
Pacira Pharmaceuticals, Inc 100
Early research (Phase 1)Study completedNCT00416923
What this trial is testing

Intrathecal Rituximab in Treating Patients With Recurrent CNS Lymphoma

Who this might be right for
Brain and Central Nervous System TumorsLymphoma
University of California, San Francisco 10
Not applicableLooking for participantsNCT06638294
What this trial is testing

Study in Patients With Breast Cancer Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis of Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 30
Not applicableNot Yet RecruitingNCT07659652
What this trial is testing

Quality of Life for Patients With Breast Cancer Brain Metastases and Leptomeningeal Disease

Who this might be right for
Breast Cancer, Quality of LifeBreast Cancer, MetastaticBreast Cancer, Metastatic Breast Cancer+2 more
University of California, San Francisco 200
Not applicableWithdrawnNCT01438021
What this trial is testing

Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease

Who this might be right for
Leptomeningeal Metastases
City of Hope Medical Center
Next Page