Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Local Advanced Rectal Cancer”

48 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 48 results

Large-scale testing (Phase 3)Looking for participantsNCT05201430
What this trial is testing

Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Fudan University 300
Testing effectiveness (Phase 2)Active Not RecruitingNCT07090031
What this trial is testing

Perioperative Treatment With TAS-102 in Combination With Oxaliplatin for Locally Advanced Rectal Cancer

Who this might be right for
EFSpCR Rate
Qingdao Central Hospital 49
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05969847
What this trial is testing

Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal Cancer

Who this might be right for
Rectal Cancer
池畔 72
Testing effectiveness (Phase 2)UnknownNCT06239870
What this trial is testing

Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer

Who this might be right for
Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Yunnan Cancer Hospital 35
Not applicableLooking for participantsNCT06761287
What this trial is testing

Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Centre Hospitalier Universitaire Saint Pierre 20
Early research (Phase 1)Study completedNCT00020579
What this trial is testing

MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma

Who this might be right for
Cancer
National Institutes of Health Clinical Center (CC) 75
Large-scale testing (Phase 3)UnknownNCT03177382
What this trial is testing

Total Neoadjuvant Treatment vs. Chemoradiotherapy in Local Advanced Rectal Cancer With High Risk Factors

Who this might be right for
Total Neoadjuvant TreatmentChemoradiotherapyLocal Advanced Rectal Cancer+1 more
West China Hospital 458
Post-approval studies (Phase 4)UnknownNCT00274885
What this trial is testing

Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer

Who this might be right for
Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group 58
Large-scale testing (Phase 3)Looking for participantsNCT04495088
What this trial is testing

Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Ralf Hofheinz 550
Testing effectiveness (Phase 2)Looking for participantsNCT06002789
What this trial is testing

Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC

Who this might be right for
Multiple CancerColorectal Cancer
Sixth Affiliated Hospital, Sun Yat-sen University 17
Testing effectiveness (Phase 2)Active Not RecruitingNCT03391843
What this trial is testing

Neoadjuvant Chemotherapy Combined With Cetuximab for EGFR Wild Type Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer Stage III
RenJi Hospital 100
Not applicableStudy completedNCT00084773
What this trial is testing

Neoadjuvant Cetuximab, Fluorouracil, and Pelvic Irradiation in Treating Patients With Locally Advanced or Locally Recurrent Rectal Cancer

Who this might be right for
Colorectal Cancer
Memorial Sloan Kettering Cancer Center 28
Testing effectiveness (Phase 2)UnknownNCT05371197
What this trial is testing

Envafolimab as Neoadjuvant Immuntherapy in Resectable Local Advanced dMMR/MSI-H Colorectal Cancer

Who this might be right for
Colorectal CancerMismatch Repair-deficient (dMMR)Microsatellite Instability-high (MSI-H)+1 more
Third Affiliated Hospital, Sun Yat-Sen University 26
Testing effectiveness (Phase 2)Looking for participantsNCT06307548
What this trial is testing

Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer

Who this might be right for
Locally Advanced Colorectal CarcinomaRecurrent Colorectal CarcinomaStage III Colorectal Cancer
Roswell Park Cancer Institute 21
Large-scale testing (Phase 3)UnknownNCT01064999
What this trial is testing

A Trial of High Intensity Versus Low Intensity Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Fudan University 240
Testing effectiveness (Phase 2)Looking for participantsNCT06856187
What this trial is testing

Second-line Standard Treatment Sequential TAS-102 and Bevacizumab Combined With Local Treatment in Advanced Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer (CRC)
Fudan University 119
Large-scale testing (Phase 3)Study completedNCT00538850
What this trial is testing

Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain

Who this might be right for
Cancer
INSYS Therapeutics Inc 130
Not applicableStudy completedNCT04239365
What this trial is testing

Follow-up Protocol of Colorectal Endoscopic Mucosal Resection Scars

Who this might be right for
Colorectal CancerRecurrence, Local Neoplasm
Portuguese Oncology Institute, Coimbra 210
Not applicableUnknownNCT04406974
What this trial is testing

Locally Advanced Colorectal Cancer and Local Recurrences in Västra Götaland

Who this might be right for
Colorectal Neoplasms
Sahlgrenska University Hospital 4,000
Not applicableLooking for participantsNCT05772923
What this trial is testing

Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision

Who this might be right for
Organ PreservationRectal CancerQuality of Life+1 more
The Netherlands Cancer Institute 168
Next Page