Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Locally Advanced Colorectal Carcinoma”

334 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 334 results

Testing effectiveness (Phase 2)Ended earlyNCT00959946
What this trial is testing

Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer

Who this might be right for
Advanced Breast Cancer (Parts 1 and 2)Advanced Pancreatic Cancer (Part 1)Advanced Colorectal Cancer (Part 1)+2 more
Pfizer 32
Testing effectiveness (Phase 2)Study completedNCT01802320
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery

Who this might be right for
Colon Mucinous AdenocarcinomaColon Signet Ring Cell AdenocarcinomaRectal Mucinous Adenocarcinoma+13 more
National Cancer Institute (NCI) 18
Testing effectiveness (Phase 2)Looking for participantsNCT07410494
What this trial is testing

Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors

Who this might be right for
CancerBreast CancerNon-Small Cell Lung Cancer (NSCLC)+10 more
Essen Biotech 85
Testing effectiveness (Phase 2)Ended earlyNCT00006001
What this trial is testing

SU5416 in Treating Patients With Metastatic or Locally Recurrent Colorectal Cancer

Who this might be right for
Colorectal Cancer
National Cancer Institute (NCI) 37
Testing effectiveness (Phase 2)Study completedNCT03854799
What this trial is testing

Immunotherapy In Locally Advanced Rectal Cancer

Who this might be right for
Colon Rectal Cancer
Gruppo Oncologico del Nord-Ovest 101
Not applicableStudy completedNCT01822444
What this trial is testing

ANGIOPREDICT. ICORG 12-16, V3

Who this might be right for
Advanced Colorectal Cancer
Cancer Trials Ireland 76
Testing effectiveness (Phase 2)Active Not RecruitingNCT07523763
What this trial is testing

Neoadjuvant Low-dose Immunotherapy in Locally Advanced MMR-deficient Colorectal Cancer

Who this might be right for
Colorectal Cancer (MSI-H)Colorectal Cancer (CRC)
Blokhin's Russian Cancer Research Center 30
Not applicableStudy completedNCT00462501
What this trial is testing

Combination Chemotherapy and Bevacizumab With or Without Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer

Who this might be right for
Colorectal Cancer
Memorial Sloan Kettering Cancer Center 35
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05794750
What this trial is testing

Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13）

Who this might be right for
Locally Advanced Rectal Cancer
JIN JING 50
Early research (Phase 1)Active Not RecruitingNCT05907304
What this trial is testing

Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations

Who this might be right for
Advanced or Metastatic Solid Tumors
Erasca, Inc. 86
Testing effectiveness (Phase 2)UnknownNCT03944252
What this trial is testing

Cetuximab + Avelumab or Avelumab Alone for Unresectable, Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (SCCAC) Progressed After at Least One Line of Systemic Treatment (CARACAS)

Who this might be right for
Squamous Cell Anal Carcinoma
Gruppo Oncologico del Nord-Ovest 54
Early research (Phase 1)Study completedNCT04468607
What this trial is testing

BLYG8824A in Participants With Locally Advanced or Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Genentech, Inc. 46
Testing effectiveness (Phase 2)Study completedNCT04744831
What this trial is testing

Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancer

Who this might be right for
Advanced Colorectal Cancer
Daiichi Sankyo 122
Testing effectiveness (Phase 2)Looking for participantsNCT07448142
What this trial is testing

Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer

Who this might be right for
Colorectal Cancer (CRC)
Sun Yat-sen University 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT04833387
What this trial is testing

PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer

Who this might be right for
Colorectal Carcinoma
Sun Yat-sen University 30
Testing effectiveness (Phase 2)Study completedNCT00094809
What this trial is testing

Chemotherapy Administered Every 2 Weeks With or Without Pegfilgrastim in Subjects With Advanced or Metastatic Colon Cancer

Who this might be right for
Colon CancerColorectal CancerRectal Cancer
Amgen 252
Early research (Phase 1)Ended earlyNCT02933944
What this trial is testing

Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab to Assess Safety and Immune Activation in Patients With Locally Advanced Primary and Recurrent Oncogenic RAS Exon 2 Mutant Colorectal Cancer

Who this might be right for
Rectal Cancer
Targovax ASA 6
Not applicableNot Yet RecruitingNCT06879899
What this trial is testing

MRD-Guided Surveillance in Locally Advanced Mid-Low Rectal Cancer (SURVEILLANCE-III)

Who this might be right for
Colorectal Cancer (CRC)
Fudan University 139
Testing effectiveness (Phase 2)Active Not RecruitingNCT04579380
What this trial is testing

Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

Who this might be right for
Uterine NeoplasmsUterine Cervical NeoplasmsBiliary Tract Neoplasms+3 more
Seagen, a wholly owned subsidiary of Pfizer 217
Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Load More Results