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Results for “Locally Advanced Rectal Cancer (LARC)”

51 trials

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Showing 20 of 51 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT06933251
What this trial is testing

PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Guangdong Provincial People's Hospital 30
Not applicableLooking for participantsNCT06653452
What this trial is testing

Application of PET/MRI in the Evaluation of the Efficacy of Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Peking Union Medical College Hospital 30
Testing effectiveness (Phase 2)UnknownNCT05307198
What this trial is testing

Rectal Artery Infusion Chemotherapy Combined With Anti-PD1 Antibody for MSS LARC

Who this might be right for
Rectal Neoplasms
Second Affiliated Hospital, School of Medicine, Zhejiang University 38
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07381777
What this trial is testing

XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Gruppo Oncologico Italiano di Ricerca Clinica 270
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07314528
What this trial is testing

Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer

Who this might be right for
Rectal Cancer PatientsObesity &Amp; OverweightLocally Advanced Rectal Cancer (LARC)+2 more
St. James's Hospital, Ireland 42
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07243938
What this trial is testing

Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)

Who this might be right for
Locally Advanced Rectal Cancer (LARC)Locally Advanced Gastric/Gastroesophageal Junction AdenocarcinomaMetastatic Colorectal Cancer (mCRC)+1 more
Tao Zhang 70
Testing effectiveness (Phase 2)Looking for participantsNCT06911684
What this trial is testing

Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.

Who this might be right for
Rectal Cancer Patients
Sun Yat-sen University 88
Not applicableLooking for participantsNCT07393048
What this trial is testing

Application and Exploration of Personalized ctDNA-MRD Detection Technology in Predicting the Efficacy of Neoadjuvant Therapy for Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Beijing Friendship Hospital 60
Testing effectiveness (Phase 2)Study completedNCT04009876
What this trial is testing

Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Fundación de investigación HM 30
Testing effectiveness (Phase 2)Looking for participantsNCT06940388
What this trial is testing

Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer.

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
brenner baruch 134
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07580339
What this trial is testing

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 30
Testing effectiveness (Phase 2)Looking for participantsNCT06923345
What this trial is testing

Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)

Who this might be right for
Rectal CancerNeoadjuvant TherapiesImmune Checkpoint Therapy+1 more
Sixth Affiliated Hospital, Sun Yat-sen University 80
Testing effectiveness (Phase 2)Looking for participantsNCT06516445
What this trial is testing

SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC

Who this might be right for
Colorectal Cancer
Huazhong University of Science and Technology 33
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06599827
What this trial is testing

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC

Who this might be right for
Rectal Cancer
Shanghai Zhongshan Hospital 54
Not applicableUnknownNCT05070832
What this trial is testing

Hyperthermia Combined With Neoadjuvant Radiochemotherapy for LARC

Who this might be right for
HyperthermiaRadiotherapy
Peking University Third Hospital 142
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07581626
What this trial is testing

Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Chinese PLA General Hospital 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07448077
What this trial is testing

Short-course Radiotherapy in TNT Combined With Enlonstobart for pMMR LARC

Who this might be right for
Efficacy and Safety of Short-course Radiotherapy in Total Neoadjuvant Therapy Combined With Enlonstobart for pMMR Locally Advanced Rectal Cancer
Hebei Medical University Fourth Hospital 128
Large-scale testing (Phase 3)Not Yet RecruitingNCT06832917
What this trial is testing

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

Who this might be right for
Rectal Cancer
Wan He 238
Early research (Phase 1)Study completedNCT01589419
What this trial is testing

A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Capecitabine and Radiation in Patients With Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer
AbbVie (prior sponsor, Abbott) 32
Not applicableLooking for participantsNCT07474103
What this trial is testing

SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC

Who this might be right for
Rectal Cancer, Adenocarcinoma
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 49
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