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Results for “Locally Advanced Rectal Cancer (LARC)”

47 trials

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Showing 20 of 47 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT07243938
What this trial is testing

Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET)

Who this might be right for
Locally Advanced Rectal Cancer (LARC)Locally Advanced Gastric/Gastroesophageal Junction AdenocarcinomaMetastatic Colorectal Cancer (mCRC)+1 more
Tao Zhang 70
Not applicableStudy completedNCT05893667
What this trial is testing

Evaluation of Inflammatory Markers in LARC Patients

Who this might be right for
Locally Advanced Rectal Cancer
Hospital Pedro Hispano 245
Testing effectiveness (Phase 2)Looking for participantsNCT07284992
What this trial is testing

SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC

Who this might be right for
Rectal CancerAdvanced Stage Colorectal CancerRadiotherapy
Shandong Provincial Hospital 208
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07176182
What this trial is testing

Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression

Who this might be right for
Rectal Cancer PatientsRectal Cancer Stage IIRectal Cancer Stage III
Sixth Affiliated Hospital, Sun Yat-sen University 236
Not applicableStudy completedNCT07351708
What this trial is testing

Development and Validation of a Post-operative Risk Of Local Recurrence Model Integrating Serology and Evalution (PROMISE) in Local Advanced Rectal Cancer Receiving Neoadjuvant Therapy: a Multicenter Study

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Cai Zerong 2,315
Not applicableUnknownNCT05070832
What this trial is testing

Hyperthermia Combined With Neoadjuvant Radiochemotherapy for LARC

Who this might be right for
HyperthermiaRadiotherapy
Peking University Third Hospital 142
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07314528
What this trial is testing

Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer

Who this might be right for
Rectal Cancer PatientsObesity &Amp; OverweightLocally Advanced Rectal Cancer (LARC)+2 more
St. James's Hospital, Ireland 42
Testing effectiveness (Phase 2)UnknownNCT05307198
What this trial is testing

Rectal Artery Infusion Chemotherapy Combined With Anti-PD1 Antibody for MSS LARC

Who this might be right for
Rectal Neoplasms
Second Affiliated Hospital, School of Medicine, Zhejiang University 38
Testing effectiveness (Phase 2)Study completedNCT04009876
What this trial is testing

Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Fundación de investigación HM 30
Testing effectiveness (Phase 2)Looking for participantsNCT06911684
What this trial is testing

Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.

Who this might be right for
Rectal Cancer Patients
Sun Yat-sen University 88
Testing effectiveness (Phase 2)Active Not RecruitingNCT06933251
What this trial is testing

PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Guangdong Provincial People's Hospital 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07381777
What this trial is testing

XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Gruppo Oncologico Italiano di Ricerca Clinica 270
Not applicableLooking for participantsNCT06761287
What this trial is testing

Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Centre Hospitalier Universitaire Saint Pierre 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06599827
What this trial is testing

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC

Who this might be right for
Rectal Cancer
Shanghai Zhongshan Hospital 54
Testing effectiveness (Phase 2)UnknownNCT05575635
What this trial is testing

Neoadjuvant Treatment of Fruquintinib Combined With Concurrent Chemoradiotherapy for LARC

Who this might be right for
Rectal Cancer
Henan Provincial People's Hospital 40
Large-scale testing (Phase 3)Not Yet RecruitingNCT06832917
What this trial is testing

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

Who this might be right for
Rectal Cancer
Wan He 238
Testing effectiveness (Phase 2)Looking for participantsNCT06923345
What this trial is testing

Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)

Who this might be right for
Rectal CancerNeoadjuvant TherapiesImmune Checkpoint Therapy+1 more
Sixth Affiliated Hospital, Sun Yat-sen University 80
Not applicableStudy completedNCT07049627
What this trial is testing

AI-Based Prediction of Pathological Response in Rectal Cancer Patients Receiving Total Neoadjuvant Therapy

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Ankara Etlik City Hospital 93
Testing effectiveness (Phase 2)Looking for participantsNCT06802666
What this trial is testing

Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal CancerNeoadjuvant Therapy
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 45
Testing effectiveness (Phase 2)Looking for participantsNCT05245474
What this trial is testing

Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer
Beijing Friendship Hospital 186
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