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Results for “Locally Advanced Rectal Cancer (LARC)”

57 trials

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Showing 20 of 57 results

Not applicableLooking for participantsNCT06761287
What this trial is testing

Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Centre Hospitalier Universitaire Saint Pierre 20
Not applicableLooking for participantsNCT06653452
What this trial is testing

Application of PET/MRI in the Evaluation of the Efficacy of Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Peking Union Medical College Hospital 30
Large-scale testing (Phase 3)Not Yet RecruitingNCT07596290
What this trial is testing

Yang et al. Anti-PD-1/CTLA-4 Dual Immunotherapy for LARC

Who this might be right for
Locally Advanced Rectal AdenocarcinomaNeoadjuvant ChemoradiationNeoadjuvant Immunotherapy
Beijing Friendship Hospital 342
Testing effectiveness (Phase 2)Looking for participantsNCT07284992
What this trial is testing

SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC

Who this might be right for
Rectal CancerAdvanced Stage Colorectal CancerRadiotherapy
Shandong Provincial Hospital 208
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07381777
What this trial is testing

XELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) Patients

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Gruppo Oncologico Italiano di Ricerca Clinica 270
Testing effectiveness (Phase 2)Looking for participantsNCT07347951
What this trial is testing

A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
First Affiliated Hospital of Wenzhou Medical University 30
Testing effectiveness (Phase 2)Looking for participantsNCT06923345
What this trial is testing

Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)

Who this might be right for
Rectal CancerNeoadjuvant TherapiesImmune Checkpoint Therapy+1 more
Sixth Affiliated Hospital, Sun Yat-sen University 80
Testing effectiveness (Phase 2)Looking for participantsNCT07646639
What this trial is testing

Different-Dose SCRT Plus CAPOX, PD-1 Blockade and IL-2 in LARC

Who this might be right for
Rectal CancerRadiotherapy
The First Affiliated Hospital with Nanjing Medical University 122
Testing effectiveness (Phase 2)Looking for participantsNCT06802666
What this trial is testing

Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal CancerNeoadjuvant Therapy
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 45
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07765667
What this trial is testing

NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC

Who this might be right for
Rectal AdenocarcinomaHigh-Risk CancerMSS
Sixth Affiliated Hospital, Sun Yat-sen University 100
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07314528
What this trial is testing

Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer

Who this might be right for
Rectal Cancer PatientsObesity &Amp; OverweightLocally Advanced Rectal Cancer (LARC)+2 more
St. James's Hospital, Ireland 42
Not applicableNot Yet RecruitingNCT07738042
What this trial is testing

To Explore a Single-arm Phase II Study on Intestinal Microbiota Transplantation Combined With Neoadjuvant Immunotherapy and Chemoradiotherapy for Locally Advanced Rectal Cancer Under MSS/pMMR

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Tianjin Medical University Cancer Institute and Hospital 46
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07175636
What this trial is testing

QL1706 With Short-Course Radiotherapy and Chemotherapy for MSS Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)Mismatch Repair-Proficient (pMMR) Rectal CancerNon-metastatic Rectal Cancer
Sun Yat-sen University 66
Testing effectiveness (Phase 2)Looking for participantsNCT07040098
What this trial is testing

Optimizing Immunotherapy Combined With Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 228
Large-scale testing (Phase 3)Not Yet RecruitingNCT07740720
What this trial is testing

The Duration of Dostarlimab in Untreated Mismatch Repair Deficient (dMMR)/ Microsatellite Instability-high (MSI-H) Locally Advanced Rectal Cancer

Who this might be right for
Neoplasms, Rectal
GlaxoSmithKline 90
Testing effectiveness (Phase 2)Looking for participantsNCT07176182
What this trial is testing

Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression

Who this might be right for
Rectal Cancer PatientsRectal Cancer Stage IIRectal Cancer Stage III
Sixth Affiliated Hospital, Sun Yat-sen University 236
Testing effectiveness (Phase 2)Study completedNCT04009876
What this trial is testing

Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Fundación de investigación HM 30
Testing effectiveness (Phase 2)Looking for participantsNCT06940388
What this trial is testing

Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer.

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
brenner baruch 134
Testing effectiveness (Phase 2)Looking for participantsNCT06911684
What this trial is testing

Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.

Who this might be right for
Rectal Cancer Patients
Sun Yat-sen University 88
Not applicableActive Not RecruitingNCT06843655
What this trial is testing

Radiological Markers in Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Carcinoma
IRCCS San Raffaele 179
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