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Results for “MLL Rearrangement”

19 trials

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Showing 19 of 19 results

Early research (Phase 1)Not Yet RecruitingNCT07355335
What this trial is testing

Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML

Who this might be right for
KMT2A-rearrangedNPM1-mutant Refractory or Relapsed AML
Massachusetts General Hospital 24
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple Myeloma+1 more
Sumitomo Pharma America, Inc. 606
Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
Testing effectiveness (Phase 2)Ended earlyNCT03724084
What this trial is testing

Pinometostat With Standard Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and MLL Gene Rearrangement

Who this might be right for
Acute Myeloid Leukemia
National Cancer Institute (NCI) 6
Early research (Phase 1)Looking for participantsNCT06222580
What this trial is testing

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia With FLT3/ITD MutationAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+2 more
Uma Borate 30
Early research (Phase 1)Looking for participantsNCT05886049
What this trial is testing

A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+1 more
National Cancer Institute (NCI) 38
Testing effectiveness (Phase 2)Study completedNCT02828358
What this trial is testing

Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

Who this might be right for
Acute Leukemia of Ambiguous LineageB Acute Lymphoblastic LeukemiaMixed Phenotype Acute Leukemia
National Cancer Institute (NCI) 78
Early research (Phase 1)Study completedNCT05326516
What this trial is testing

Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia

Who this might be right for
Relapsed/Refractory LeukemiasAcute Lymphoblastic LeukemiaAcute Lymphocytic Leukemia+3 more
Syndax Pharmaceuticals 30
Not applicableLooking for participantsNCT07559695
What this trial is testing

A Real-world Study on the Efficacy and Safety of Menin Inhibitors as Maintenance After Allo-HSCT

Who this might be right for
Menin InhibitorsAcute LeukemiaPost Hematopoietic Stem Cell Transplantation+4 more
The First Affiliated Hospital of Soochow University 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT06052813
What this trial is testing

BN104 in the Treatment of Acute Leukemia

Who this might be right for
ALL, AdultAML, AdultAcute Leukaemia+4 more
Institut de Recherches Internationales Servier (I.R.I.S.) 66
Testing effectiveness (Phase 2)Looking for participantsNCT07101497
What this trial is testing

Phase 2 Trial of BN104 as Post-HSCT Maintenance in Acute Leukemia

Who this might be right for
Menin InhibitorsPost Hematopoietic Stem Cell TransplantationMaintenance Therapy+4 more
The First Affiliated Hospital of Soochow University 60
Early research (Phase 1)Study completedNCT02141828
What this trial is testing

Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patients With Relapsed/Refractory Leukemias Bearing a Rearrangement of the MLL Gene

Who this might be right for
LeukemiaAcute Myeloid LeukemiaAcute Lymphocytic Leukemia+1 more
Epizyme, Inc. 18
Testing effectiveness (Phase 2)Looking for participantsNCT07155226
What this trial is testing

Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

Who this might be right for
Acute Lymphoblastic LeukaemiaAcute Myeloid LeukaemiaHigher-risk Myelodysplastic Syndromes
AstraZeneca 84
Early research (Phase 1)Looking for participantsNCT06440135
What this trial is testing

Ziftomenib Maintenance Post Allo-HCT

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia in RemissionNPM1 Mutation+1 more
Massachusetts General Hospital 22
Testing effectiveness (Phase 2)Study completedNCT03701295
What this trial is testing

Pinometostat and Azacitidine in Treating Patients With Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia With 11q23 Rearrangement

Who this might be right for
Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-MLLLeukemia CutisRecurrent Acute Myeloid Leukemia+1 more
National Cancer Institute (NCI) 1
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07563010
What this trial is testing

Menin-Inhibitor Targeted Maintenance in AML

Who this might be right for
Relapsed Adult AMLStem Cell Transplant ComplicationsAcute Myeloid Leukemia+1 more
Center for International Blood and Marrow Transplant Research 146
Not applicableLooking for participantsNCT07537738
What this trial is testing

Leukemia Stem Cell-based Assay to Predict Relapse and Survival in Patients With Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia (AML)MLL Rearrangement
Peking University People's Hospital 210
Early research (Phase 1)Looking for participantsNCT06001788
What this trial is testing

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Who this might be right for
AMLAML With Mutated NPM1Hematologic Malignancy+9 more
Kura Oncology, Inc. 171
Testing effectiveness (Phase 2)Looking for participantsNCT04065399
What this trial is testing

Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMixed Lineage Acute Leukemia+2 more
Syndax Pharmaceuticals 447