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Results for “MSI-H Tumors”

212 trials

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Showing 20 of 212 results

Testing effectiveness (Phase 2)UnknownNCT03491345
What this trial is testing

K-Basket, Avelumab, Biomarker-driven, Advanced Solid Tumor

Who this might be right for
PD-L1 Positive Mutation TumorEBV Positive Mutation TumorMSI-H Mutation Tumor+1 more
Yonsei University 60
Testing effectiveness (Phase 2)Active Not RecruitingNCT05199272
What this trial is testing

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

Who this might be right for
Solid TumorClear Cell Renal Cell CarcinomaEpithelial Ovarian Cancer+6 more
23andMe, Inc. 141
Not applicableEnrolling By InvitationNCT07646574
What this trial is testing

Non-surgical Management After NIT for dMMR/MSI-H GC

Who this might be right for
Non-surgical Management;dMMR/MSI-H Gastric Cancer;Neoadjuvant Immunotherapy
Yong Zhou 12
Testing effectiveness (Phase 2)Looking for participantsNCT02332668
What this trial is testing

Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

Who this might be right for
MelanomaLymphomaSolid Tumor+2 more
Merck Sharp & Dohme LLC 370
Very early researchEnded earlyNCT03454243
What this trial is testing

Oral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced or Metastatic Solid Tumors
Hoffmann-La Roche 1
Large-scale testing (Phase 3)Looking for participantsNCT06346197
What this trial is testing

Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas

Who this might be right for
Gastric CancerMSI-HMetastatic Cancer+1 more
Centre Leon Berard 132
Testing effectiveness (Phase 2)Active Not RecruitingNCT03836352
What this trial is testing

Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors

Who this might be right for
Ovarian CancerHepatocellular CarcinomaNon-small Cell Lung Cancer+2 more
ImmunoVaccine Technologies, Inc. (IMV Inc.) 184
Early research (Phase 1)Ended earlyNCT04116320
What this trial is testing

Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors

Who this might be right for
MelanomaBreast CancerMerkel Cell Carcinoma+10 more
Craig L Slingluff, Jr 5
Not applicableLooking for participantsNCT06477991
What this trial is testing

The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial.

Who this might be right for
Clinical Complete Response Rate With Negative MRD
Yunnan Cancer Hospital 22
Not applicableStudy completedNCT03495674
What this trial is testing

Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome

Who this might be right for
High-Frequency Microsatellite InstabilityMismatch Repair Gene MutationMutation-Negative Lynch Syndrome+1 more
M.D. Anderson Cancer Center 21
Testing effectiveness (Phase 2)Ended earlyNCT04800627
What this trial is testing

Pevonedistat and Pembrolizumab for the Treatment of dMMR/MSI-H Metastatic or Locally Advanced Unresectable Solid Tumor

Who this might be right for
Locally Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
M.D. Anderson Cancer Center 2
Testing effectiveness (Phase 2)UnknownNCT03941574
What this trial is testing

A Clinical Study to Evaluate HLX10 Monotherapy for the Treatment of MSI-H or dMMR Solid Tumors That Failed to Respond to Standard Therapy

Who this might be right for
MSI-H Solid Malignant Tumor
Shanghai Henlius Biotech 108
Large-scale testing (Phase 3)Looking for participantsNCT07412613
What this trial is testing

Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer

Who this might be right for
Resectable Colon CancerMSI-H/dMMR Colorectal Cancer
Akeso 386
Testing effectiveness (Phase 2)Study completedNCT03241173
What this trial is testing

A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies

Who this might be right for
Advanced Malignancies
Incyte Biosciences International Sàrl 52
Testing effectiveness (Phase 2)Looking for participantsNCT04774419
What this trial is testing

Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery

Who this might be right for
Endometrial Cancer
Memorial Sloan Kettering Cancer Center 62
Testing effectiveness (Phase 2)Ended earlyNCT03277352
What this trial is testing

INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies

Who this might be right for
Advanced MalignanciesMetastatic Cancer
Incyte Biosciences International Sàrl 10
Testing effectiveness (Phase 2)Study completedNCT03126110
What this trial is testing

Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies

Who this might be right for
Advanced MalignanciesMetastatic Cancer
Incyte Biosciences International Sàrl 145
Testing effectiveness (Phase 2)Active Not RecruitingNCT03607890
What this trial is testing

Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor

Who this might be right for
Refractory MSI - H Solid Tumors Prior of PD-(L) 1 TherapyMSI-H Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 38
Not applicableLooking for participantsNCT07327489
What this trial is testing

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

Who this might be right for
CancerImmunotherapyAdvanced Solid Tumors Cancer+12 more
Elephas 2,000
Testing effectiveness (Phase 2)Active Not RecruitingNCT05118724
What this trial is testing

Atezolizumab in Patients With MSI-h/MMR-D Stage II High Risk and Stage III Colorectal Cancer Ineligible for Oxaliplatin

Who this might be right for
Colorectal Cancer
AIO-Studien-gGmbH 80
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