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Results for “MTAP Negative”

21 trials

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Showing 20 of 21 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT05335941
What this trial is testing

Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma

Who this might be right for
Urothelial CarcinomaMetastatic Cancer
M.D. Anderson Cancer Center 10
Early research (Phase 1)Ended earlyNCT03435250
What this trial is testing

Study of AG-270 in Participants With Advanced Solid Tumors or Lymphoma With MTAP Loss

Who this might be right for
Advanced Solid TumorsLymphoma
Institut de Recherches Internationales Servier 123
Early research (Phase 1)Looking for participantsNCT07382544
What this trial is testing

Phase 1b Trial of BMS-986504 in Combination With Olaparib in Patients With MTAP Loss

Who this might be right for
Advanced CancerSolid Tumor
M.D. Anderson Cancer Center 36
Testing effectiveness (Phase 2)Looking for participantsNCT06810544
What this trial is testing

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Who this might be right for
Non Small Cell Lung CancerGlioma Glioblastoma MultiformeGlioma, Malignant+4 more
Tango Therapeutics, Inc. 191
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07602946
What this trial is testing

SELECTmeso A Trial for Patients With Relapsed Malignant Mesothelioma SELECTmeso1 A Trial of BMS-986504 in Patients With MTAP-deficient Relapsed Mesothelioma

Who this might be right for
Mesothelioma
University of Southampton 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07579221
What this trial is testing

Ph1/2 Trial Of Navlimetostat With Pumitamig In MTAP-Deficient Advanced Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
M.D. Anderson Cancer Center 17
Early research (Phase 1)Looking for participantsNCT06589596
What this trial is testing

An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumor
BeOne Medicines 525
Testing effectiveness (Phase 2)Looking for participantsNCT06630416
What this trial is testing

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

Who this might be right for
Metastatic Bladder Urothelial CarcinomaMetastatic Malignant Solid NeoplasmStage IV Bladder Cancer AJCC v8+1 more
Northwestern University 64
Testing effectiveness (Phase 2)Looking for participantsNCT06922357
What this trial is testing

A Phase I/II of HRS-6719 in Patients With Advanced/Metastatic Solid Tumors

Who this might be right for
Advanced/Metastatic Solid Tumors
Shandong Suncadia Medicine Co., Ltd. 120
Testing effectiveness (Phase 2)Looking for participantsNCT06922591
What this trial is testing

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

Who this might be right for
PDACPDAC - Pancreatic Ductal AdenocarcinomaNSCLC+5 more
Tango Therapeutics, Inc. 183
Very early researchLooking for participantsNCT06883747
What this trial is testing

Clinical Trial of BMS-986504 in Recurrent GBM Patients

Who this might be right for
Glioblastoma WHO Grade IV
Nader Sanai 12
Testing effectiveness (Phase 2)Looking for participantsNCT06130553
What this trial is testing

AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors

Who this might be right for
Advanced Solid Tumors That Are MTAP Deficient
AstraZeneca 334
Not applicableStudy completedNCT03361358
What this trial is testing

Pre-Screening Study to Identify MTAP Loss in Advanced Solid Tumors or Lymphoma

Who this might be right for
Advanced Solid TumorsLymphoma
Agios Pharmaceuticals, Inc. 44
Testing effectiveness (Phase 2)Looking for participantsNCT06855771
What this trial is testing

Navlimetostat (BMS-986504) Alone or in Combination With Izalontamab Brengitecan in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion or MTAP Loss (MountainTAP-9)

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Bristol-Myers Squibb 182
Testing effectiveness (Phase 2)Looking for participantsNCT06137144
What this trial is testing

AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.

Who this might be right for
LymphomaNon-Hodgkin LymphomaHodgkin Lymphoma+4 more
AstraZeneca 161
Early research (Phase 1)Looking for participantsNCT07288957
What this trial is testing

A Early Study of ABSK131 in Patients With Advanced/Metastatic Solid Tumors

Who this might be right for
Solid Tumors (Phase 1)
Abbisko Therapeutics Co, Ltd 266
Early research (Phase 1)Study completedNCT00075894
What this trial is testing

Alanosine in Treating Patients With Progressive or Recurrent Malignant Gliomas

Who this might be right for
Brain and Central Nervous System Tumors
National Cancer Institute (NCI) 18
Testing effectiveness (Phase 2)Study completedNCT00062283
What this trial is testing

Alanosine in Treating Patients With Cancer

Who this might be right for
Lung CancerMalignant MesotheliomaPancreatic Cancer+1 more
Memorial Sloan Kettering Cancer Center
Testing effectiveness (Phase 2)Active Not RecruitingNCT03744793
What this trial is testing

Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer

Who this might be right for
Infiltrating Bladder Urothelial Carcinoma Sarcomatoid VariantInfiltrating Bladder Urothelial Carcinoma With Glandular DifferentiationInfiltrating Bladder Urothelial Carcinoma With Squamous Differentiation+4 more
M.D. Anderson Cancer Center
Testing effectiveness (Phase 2)Looking for participantsNCT06971523
What this trial is testing

A Phase I/II Clinical Study of CTS3497 in Patients With MTAP Deficient Malignacies

Who this might be right for
Solid TumorLymphoma
CytosinLab Therapeutics Co., Ltd. 224
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