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Results for “MTAP-deleted NSCLC”

15 trials

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Showing 15 of 15 results

Early research (Phase 1)Active Not RecruitingNCT04794699
What this trial is testing

Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion

Who this might be right for
Solid Tumor
IDEAYA Biosciences 169
Early research (Phase 1)Not Yet RecruitingNCT07583771
What this trial is testing

A Phase Ⅰ Study of CS08399 in Participants With MTAP-deleted Solid Tumors and Lymphoma

Who this might be right for
Pancreatic AdenocarcinomaNon Small Cell Lung CancerAdvanced Solid Tumors+2 more
Chipscreen Biosciences, Ltd. 186
Early research (Phase 1)Looking for participantsNCT05245500
What this trial is testing

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Who this might be right for
MesotheliomaNon Small Cell Lung CancerMalignant Peripheral Nerve Sheath Tumors+3 more
Bristol-Myers Squibb 336
Testing effectiveness (Phase 2)Active Not RecruitingNCT06593522
What this trial is testing

Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)

Who this might be right for
MTAP-deleted NSCLC
Amgen 61
Testing effectiveness (Phase 2)Active Not RecruitingNCT06188702
What this trial is testing

S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP

Who this might be right for
MTAP-deleted Solid Tumors
Servier Bio-Innovation LLC 60
Early research (Phase 1)Not Yet RecruitingNCT07699757
What this trial is testing

HSK41959 With Standard Therapy in Solid Tumors With MTAP Deletion

Who this might be right for
Non-Small Cell Lung CancerPancreatic Ductal Adenocarcinoma (mPDAC)Advanced Solid Tumors
Haisco Pharmaceutical Group Co., Ltd. 258
Testing effectiveness (Phase 2)Looking for participantsNCT07492680
What this trial is testing

BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

Who this might be right for
Solid Tumors
Bristol-Myers Squibb 260
Testing effectiveness (Phase 2)Looking for participantsNCT06855771
What this trial is testing

Navlimetostat (BMS-986504) Alone or in Combination With Izalontamab Brengitecan in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion or MTAP Loss (MountainTAP-9)

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Bristol-Myers Squibb 182
Testing effectiveness (Phase 2)Looking for participantsNCT06922591
What this trial is testing

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

Who this might be right for
PDACPDAC - Pancreatic Ductal AdenocarcinomaNSCLC+5 more
Tango Therapeutics, Inc. 183
Testing effectiveness (Phase 2)Ended earlyNCT05275478
What this trial is testing

Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

Who this might be right for
Locally Advanced Solid Tumor
Tango Therapeutics, Inc. 110
Large-scale testing (Phase 3)Looking for participantsNCT07063745
What this trial is testing

Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

Who this might be right for
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Bristol-Myers Squibb 590
Early research (Phase 1)Looking for participantsNCT07277413
What this trial is testing

IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

Who this might be right for
NSCLC AdenocarcinomaGastroesophageal Cancer (GC)Gastric Adenocarcinoma+10 more
IDEAYA Biosciences 260
Early research (Phase 1)Active Not RecruitingNCT06333951
What this trial is testing

Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

Who this might be right for
Thoracic TumorsNon-small Cell Lung Cancer
Amgen 49
Testing effectiveness (Phase 2)Looking for participantsNCT05732831
What this trial is testing

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

Who this might be right for
Locally Advanced Solid Tumor
Tango Therapeutics, Inc. 225
Testing effectiveness (Phase 2)Looking for participantsNCT06914128
What this trial is testing

PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

Who this might be right for
MTAP-deleted Solid Tumors
Bayer 450