Testing effectiveness (Phase 2)Not Yet RecruitingNCT06942390What this trial is testingTopical Metformin Versus Topical Ketotifen in Melasma TreatmentWho this might be right forMelasma Assiut University 60
Not applicableUnknownNCT06268496What this trial is testingEfficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 OriginsWho this might be right forHyperpigmentation Cosmetique Active International 60
Not applicableStudy completedNCT07644871What this trial is testingA 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face HyperpigmentationWho this might be right forHyperpigmentationMelasmaDark Spots Revision Skincare 18
Not applicableLooking for participantsNCT07202156What this trial is testingUltrasound-Enhanced Delivery of Compound TXA Solution in MelasmaWho this might be right forMelasma (Facial Melasma) The First Affiliated Hospital with Nanjing Medical University 35
Not applicableUnknownNCT06253468What this trial is testingEfficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 OriginsWho this might be right forHyperpigmentation Cosmetique Active International 72
Not applicableUnknownNCT04765930What this trial is testingCombined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in MelasmaWho this might be right forHyperpigmentationMelasmaPRP+1 more Cairo University 30
Not applicableStudy completedNCT05864417What this trial is testingAssess Effect of Two Facial Sunscreens in Improving Wrinkles, Fine Lines and Melasma in Adult ParticipantsWho this might be right forHealthy Johnson & Johnson Consumer Inc. (J&JCI) 40
Post-approval studies (Phase 4)UnknownNCT03923062What this trial is testingDifferent Dermatological Approaches the Treatment of MelasmaWho this might be right forMelasma Assiut University 40
Not applicableLooking for participantsNCT07071363What this trial is testingCOMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYSWho this might be right forHealthyMelasma (Facial Melasma)Epidermal Melasma Laboratoire Dermatologique ACM 40
Very early researchWithdrawnNCT02812719What this trial is testingTreatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid PeelWho this might be right forMelasma Boston Medical Center
Not applicableLooking for participantsNCT07540702What this trial is testingInjectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for MelasmaWho this might be right forMelasmaFacial Melasma Kasr El Aini Hospital 21
Not applicableStudy completedNCT05013801What this trial is testingA Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate MelasmaWho this might be right forMelasma Unilever R&D 96
Not applicableStudy completedNCT04359719What this trial is testingComparison Between Free Thyroxine and Thyroid Stimulating Hormone Levels on Melasma SeverityWho this might be right forMelasma Universitas Indonesia 48
Large-scale testing (Phase 3)Temporarily pausedNCT00717652What this trial is testingEfficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of MelasmaWho this might be right forMelasma Azidus Brasil 110
Post-approval studies (Phase 4)UnknownNCT03153852What this trial is testingModified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic AcidWho this might be right forMelasma Assiut University 30
Testing effectiveness (Phase 2)Study completedNCT01085279What this trial is testingFractional Laser as Treatment Option for Various Pigment Disorders (Fractional-3)Who this might be right forPigmentation Disorder Netherlands Institute for Pigment Disorders 29
Testing effectiveness (Phase 2)Study completedNCT06957834What this trial is testingEfficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled StudyWho this might be right forMelasma National Skin Centre 20
Not applicableStudy completedNCT06313307What this trial is testingThe Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R AntagonistWho this might be right forMelasma Second Affiliated Hospital of Xi'an Jiaotong University 16
Post-approval studies (Phase 4)Not Yet RecruitingNCT07732192What this trial is testingOral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in MelasmaWho this might be right forMelasmaMelasma (Facial Melasma) Combined Military Hospital Abbottabad 128
Not applicableUnknownNCT06491771What this trial is testingA Cryotherapy With Tranexamic Acid Versus Normal Saline in the Treatment of MelasmaWho this might be right forCryotherapy Effect Mahidol University 18