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Results for “Mesothelin (Msln)”

121 trials

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Showing 20 of 121 results

Early research (Phase 1)Ended earlyNCT06523803
What this trial is testing

ZW171 in Participants With Advanced or Metastatic Mesothelin-expressing Cancers

Who this might be right for
Mesothelin-expressing Advanced Cancers
Zymeworks BC Inc. 32
Testing effectiveness (Phase 2)Looking for participantsNCT07480928
What this trial is testing

Dual-Targeting CAR-NK Cells Targeting Mesothelin (MSLN) and MUC1 in Advanced Pancreatic Ductal Adenocarcinoma

Who this might be right for
Pancreatic Ductal Adenocarcinoma (PDAC)Unresectable Locally Advanced or Metastatic Disease
Beijing Biotech 42
Early research (Phase 1)Ended earlyNCT00585845
What this trial is testing

Study of Safety and Tolerability of Intravenous CRS-207 in Adults With Selected Advanced Solid Tumors Who Have Failed or Who Are Not Candidates for Standard Treatment

Who this might be right for
Malignant Epithelial MesotheliomaAdenocarcinoma of the PancreasCarcinoma, Non-Small-Cell Lung+1 more
Anza Therapeutics, Inc. 17
Testing effectiveness (Phase 2)Ended earlyNCT03644550
What this trial is testing

Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant Mesothelioma

Who this might be right for
Mesothelioma
National Cancer Institute (NCI) 18
Early research (Phase 1)Study completedNCT01521325
What this trial is testing

A Single-Dose Pilot Study of Radiolabeled Amatuximab (MORAb-009) in Mesothelin Over Expressing Cancers

Who this might be right for
MesotheliomaPancreatic CancerOvarian Cancer+1 more
Morphotek 6
Not applicableUnknownNCT04203459
What this trial is testing

The Mechanism of Enhancing the Anti-tumor Effects of CAR-T on PC by Gut Microbiota Regulation

Who this might be right for
Pancreatic CancerGut MicrobiotaCAR-T
First Affiliated Hospital of Harbin Medical University 80
Early research (Phase 1)UnknownNCT02580747
What this trial is testing

Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso

Who this might be right for
Malignant MesotheliomaPancreatic CancerOvarian Tumor+3 more
Chinese PLA General Hospital 20
Early research (Phase 1)WithdrawnNCT05531708
What this trial is testing

Exploratory Study of Novel MSLN CAR-T Cell Therapy in Patients With MSLN-positive Advanced Refractory Solid Tumors

Who this might be right for
Mesothelin-positive Advanced Refractory Solid Tumors
Shanghai Pudong Hospital
Early research (Phase 1)Study completedNCT02751918
What this trial is testing

Phase Ib Study of Anetumab Ravtansine in Combination With Pegylated Liposomal Doxorubicin in Patients With Recurrent Mesothelin-expressing Platinum-resistant Cancer

Who this might be right for
Ovarian Neoplasms
Bayer 65
Testing effectiveness (Phase 2)Ended earlyNCT02341625
What this trial is testing

BMS-986148 in Patients With Select Advanced Solid Tumors

Who this might be right for
Advanced Cancer
Bristol-Myers Squibb 126
Testing effectiveness (Phase 2)Looking for participantsNCT07467863
What this trial is testing

Dual-Target CAR-NK Cells Directed Against MSLN, EGFR, or HER2 in Advanced NSCLC

Who this might be right for
Non-Small Cell Lung CancerAdvanced/Metastatic NSCLC
Beijing Biotech 48
Early research (Phase 1)Ended earlyNCT05164666
What this trial is testing

TAK-103 in Adult With Solid Tumors

Who this might be right for
Solid Tumors
Takeda 2
Testing effectiveness (Phase 2)Looking for participantsNCT07598955
What this trial is testing

Target-Selected CAR-NK Cells (CD30, CD5, or Mesothelin) for Relapsed/Refractory B2 Thymoma or Thymic Carcinoma

Who this might be right for
B2 ThymomaThymic Carcinoma
Beijing Biotech 36
Early research (Phase 1)Looking for participantsNCT05779917
What this trial is testing

Mesothelin/GPC3/GUCY2C-CAR-T Cells Against Cancers

Who this might be right for
Pancreas CancerCAR-T Cell TherapyMesothelin+1 more
Second Affiliated Hospital of Guangzhou Medical University 30
Testing effectiveness (Phase 2)Looking for participantsNCT07641023
What this trial is testing

Dual-Target CAR-NK Cells Targeting MSLN, EGFR, or HER2 in Advanced NSCLC

Who this might be right for
Non-Small Cell Lung CancerAdvanced/Metastatic
Beijing Biotech 60
Early research (Phase 1)Ended earlyNCT03608618
What this trial is testing

Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma

Who this might be right for
Peritoneal MesotheliomaFallopian Tube AdenocarcinomaAdenocarcinoma of the Ovary+1 more
MaxCyte, Inc. 14
Testing effectiveness (Phase 2)UnknownNCT03182803
What this trial is testing

CTLA-4 and PD-1 Antibodies Expressing Mesothelin-CAR-T Cells for Mesothelin Positive Advanced Solid Tumor

Who this might be right for
Advanced Solid Tumor
Shanghai Cell Therapy Research Institute 40
Early research (Phase 1)UnknownNCT02706782
What this trial is testing

Mesothelin Redirected Autologous T Cells for Advanced Pancreatic Carcinoma

Who this might be right for
Pancreatic Cancer
Shanghai GeneChem Co., Ltd. 30
Testing effectiveness (Phase 2)Looking for participantsNCT07066995
What this trial is testing

Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer

Who this might be right for
Pancreatic CancerPancreatic CarcinomaPancreatic Cancer Non-resectable+1 more
Essen Biotech 60
Early research (Phase 1)Ended earlyNCT04809766
What this trial is testing

Mesothelin-Specific T-Cells (FH-TCR-Tᴍsʟɴ) for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma

Who this might be right for
Metastatic Pancreatic Ductal AdenocarcinomaStage IV Pancreatic Cancer AJCC v8
Fred Hutchinson Cancer Center 9
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