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Results for “Metastatic HER2-positive Breast Cancer With Brain Metastasis”

50 trials

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Showing 20 of 50 results

Testing effectiveness (Phase 2)Looking for participantsNCT04923542
What this trial is testing

SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases

Who this might be right for
Brain MetastasesHR+ Metastatic Breast Cancer
H. Lee Moffitt Cancer Center and Research Institute 31
Testing effectiveness (Phase 2)Active Not RecruitingNCT04538742
What this trial is testing

A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
AstraZeneca 245
Testing effectiveness (Phase 2)Looking for participantsNCT04348747
What this trial is testing

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Who this might be right for
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Malignant Neoplasm in the BrainMetastatic Triple-Negative Breast Carcinoma+1 more
Roswell Park Cancer Institute 23
Testing effectiveness (Phase 2)WithdrawnNCT03203616
What this trial is testing

Kadcyla In pAtients With bRAin Metastasis

Who this might be right for
Metastatic HER2-positive Breast Cancer With Brain Metastasis
Jules Bordet Institute
Testing effectiveness (Phase 2)Study completedNCT01622868
What this trial is testing

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

Who this might be right for
HER2-Positive Breast CarcinomaInvasive Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+2 more
National Cancer Institute (NCI) 143
Large-scale testing (Phase 3)Looking for participantsNCT03418961
What this trial is testing

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

Who this might be right for
CardiotoxicityHER2/Neu PositiveMetastatic Malignant Neoplasm in the Brain+2 more
SWOG Cancer Research Network 491
Early research (Phase 1)Active Not RecruitingNCT03696030
What this trial is testing

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Who this might be right for
Malignant NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges+2 more
City of Hope Medical Center 24
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06975462
What this trial is testing

A Phase II Study of SHR-A1811 Combined With Radiotherapy in HER2-positive and HER2-low Breast Cancer Brain Metastases

Who this might be right for
Breast Cancer Metastatic
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 30
Testing effectiveness (Phase 2)Study completedNCT01441596
What this trial is testing

Lux-Breast 3; Afatinib Alone or in Combination With Vinorelbine in Patients With Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer Suffering From Brain Metastases

Who this might be right for
Breast NeoplasmsNeoplasm Metastasis
Boehringer Ingelheim 121
Not applicableUnknownNCT06015100
What this trial is testing

Efficacy and Safety of Inetetamab Plus Pyrotiniband and Capecitabine in HER2-positive Metastatic Breast Cancer Patients With or Without Brain Metastasis

Who this might be right for
Breast Cancer
Yan Xue 40
Testing effectiveness (Phase 2)Study completedNCT00967031
What this trial is testing

Lapatinib Ditosylate and Capecitabine in Treating Patients With Stage IV Breast Cancer and Brain Metastases

Who this might be right for
Breast CancerMetastatic Cancer
UNICANCER 45
Testing effectiveness (Phase 2)Study completedNCT02260531
What this trial is testing

Cabozantinib +/- Trastuzumab In Breast Cancer Patients w/ Brain Metastases

Who this might be right for
Breast CancerBrain Tumor - Metastatic
Dana-Farber Cancer Institute 36
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07177950
What this trial is testing

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

Who this might be right for
Breast CancerBrain MetastasesLeptomeningeal Metastasis
Peking University Cancer Hospital & Institute 51
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07152782
What this trial is testing

T-DXd With or Without Neratinib for HER2 Positive Breast Cancer With Brain Metastasis

Who this might be right for
Breast Cancer With Brain MetastasisHER2-positive Breast Cancer
Fudan University 202
Testing effectiveness (Phase 2)Active Not RecruitingNCT05323955
What this trial is testing

Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib

Who this might be right for
Brain MetastasesHuman Epidermal Growth Factor 2 Positive Carcinoma of BreastAdvanced Breast Cancer
Carey Anders, M.D. 48
Testing effectiveness (Phase 2)Study completedNCT02614794
What this trial is testing

Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer

Who this might be right for
HER2 Positive Breast Cancer
Seagen Inc. 612
Testing effectiveness (Phase 2)Study completedNCT04420598
What this trial is testing

DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease

Who this might be right for
Advanced Breast CancerHER2-positive Breast CancerBrain Metastases+1 more
MedSIR 41
Testing effectiveness (Phase 2)Study completedNCT00098605
What this trial is testing

Lapatinib in Treating Brain Metastases in Patients With Stage IV Breast Cancer and Brain Metastases

Who this might be right for
Central Nervous System MetastasesHER2-positive Breast CancerMale Breast Cancer+3 more
National Cancer Institute (NCI) 37
Not applicableActive Not RecruitingNCT04030507
What this trial is testing

Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer

Who this might be right for
Breast CancerHER2-positive Breast CancerTriple Negative Breast Cancer+3 more
Brigham and Women's Hospital 214
Testing effectiveness (Phase 2)Ended earlyNCT01132664
What this trial is testing

Phase 1b/2 Study of BKM120 Plus Trastuzumab in Patients With HER2-positive Breast Cancer

Who this might be right for
Metastatic Breast CancerHER2+ Breast Cancer
Novartis Pharmaceuticals 72
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