Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Metastatic Malignant Neoplasm in the Leptomeninges”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Not applicableStudy completedNCT06592092
What this trial is testing

Clinical Study of QH104 Cell Injection for the Treatment of Meningeal Metastases of B7H3+ Solid Tumors

Who this might be right for
Solid TumorMeningeal Metastasis
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 3
Not applicableStudy completedNCT04178343
What this trial is testing

Tomotherapy for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Chinese Academy of Medical Sciences 103
Early research (Phase 1)Study completedNCT00674674
What this trial is testing

Phase 1 Intrathecal Topotecan for Neoplastic Meningitis

Who this might be right for
Neoplastic Meningitis
Baylor College of Medicine 22
Not applicableLooking for participantsNCT05746325
What this trial is testing

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Who this might be right for
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Leptomeninges+2 more
Mayo Clinic 5
Testing effectiveness (Phase 2)Study completedNCT00005811
What this trial is testing

Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment

Who this might be right for
AIDS-related Diffuse Large Cell LymphomaAIDS-related Diffuse Mixed Cell LymphomaAIDS-related Diffuse Small Cleaved Cell Lymphoma+17 more
National Cancer Institute (NCI) 77
Early research (Phase 1)Active Not RecruitingNCT04192981
What this trial is testing

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

Who this might be right for
Brain MetastasesLeptomeningeal Metastasis
Memorial Sloan Kettering Cancer Center 21
Not applicableLooking for participantsNCT06399926
What this trial is testing

Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir

Who this might be right for
Leptomeningeal MetastasisLung Cancer
Xiangya Hospital of Central South University 64
Early research (Phase 1)Study completedNCT02228369
What this trial is testing

Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, AZD3759 or AZD9291, in Patients Who Have Advanced Non-Small Cell Lung Cancer

Who this might be right for
EGFR Mutation Positive Advanced Non Small Cell Lung Cancer
AstraZeneca 108
Early research (Phase 1)Ended earlyNCT00515788
What this trial is testing

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Who this might be right for
Neoplastic Meningitis
M.D. Anderson Cancer Center 11
Post-approval studies (Phase 4)Study completedNCT00029523
What this trial is testing

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Who this might be right for
Meningeal Neoplasms
Pacira Pharmaceuticals, Inc 100
Testing effectiveness (Phase 2)UnknownNCT05813522
What this trial is testing

Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC

Who this might be right for
Non Small Cell Lung Cancer
First Affiliated Hospital of Zhejiang University 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07833657
What this trial is testing

Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal MetastasesSolid Tumors
Jiuda Zhao 28
Not applicableStudy completedNCT07386886
What this trial is testing

Development of a Novel Graded Prognostic Assessment (BC-LGPA) Model for Breast Cancer Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal Metastasis in Breast Cancer
Jian Zhang,MD 403
Not applicableNot Yet RecruitingNCT07659652
What this trial is testing

Quality of Life for Patients With Breast Cancer Brain Metastases and Leptomeningeal Disease

Who this might be right for
Breast Cancer, Quality of LifeBreast Cancer, MetastaticBreast Cancer, Metastatic Breast Cancer+2 more
University of California, San Francisco 200
Testing effectiveness (Phase 2)Study completedNCT02654106
What this trial is testing

Stereotactic Radiotherapy Plus Temozolomide for Refractory Brain Metastases

Who this might be right for
Brain Metastases
Chinese Academy of Medical Sciences 65
Testing effectiveness (Phase 2)Looking for participantsNCT06809517
What this trial is testing

Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis

Who this might be right for
Leptomeningeal MetastasisIntrathecal Drug Delivery
Guangzhou Medical University 34
Not applicableEnded earlyNCT05414123
What this trial is testing

A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide

Who this might be right for
Leptomeningeal MetastasisLeptomeningeal DiseaseLeptomeningeal Neoplasms+2 more
Biocept, Inc. 40
Early research (Phase 1)Ended earlyNCT00089245
What this trial is testing

Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer

Who this might be right for
Brain and Central Nervous System TumorsNeuroblastomaSarcoma
Y-mAbs Therapeutics 177
Not applicableUnknownNCT06410040
What this trial is testing

A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis

Who this might be right for
ALK-positive Non-small Cell Lung CancerBrain MetastasesMeningeal Metastasis
Sichuan Cancer Hospital and Research Institute 28
Testing effectiveness (Phase 2)Looking for participantsNCT06440954
What this trial is testing

Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases

Who this might be right for
Non-Small Cell Lung Cancer
Hunan Province Tumor Hospital 220
Next Page