Early research (Phase 1)Study completedNCT00674674What this trial is testingPhase 1 Intrathecal Topotecan for Neoplastic MeningitisWho this might be right forNeoplastic Meningitis Baylor College of Medicine 22
Not applicableLooking for participantsNCT05746325What this trial is testingTumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung CancerWho this might be right forAnatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Leptomeninges+2 more Mayo Clinic 5
Testing effectiveness (Phase 2)Study completedNCT00005811What this trial is testingTopotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous TreatmentWho this might be right forAIDS-related Diffuse Large Cell LymphomaAIDS-related Diffuse Mixed Cell LymphomaAIDS-related Diffuse Small Cleaved Cell Lymphoma+17 more National Cancer Institute (NCI) 77
Early research (Phase 1)Active Not RecruitingNCT04192981What this trial is testingGDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal MetastasesWho this might be right forBrain MetastasesLeptomeningeal Metastasis Memorial Sloan Kettering Cancer Center 21
Not applicableLooking for participantsNCT06399926What this trial is testingEfficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya ReservoirWho this might be right forLeptomeningeal MetastasisLung Cancer Xiangya Hospital of Central South University 64
Early research (Phase 1)Study completedNCT02228369What this trial is testingOral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, AZD3759 or AZD9291, in Patients Who Have Advanced Non-Small Cell Lung CancerWho this might be right forEGFR Mutation Positive Advanced Non Small Cell Lung Cancer AstraZeneca 108
Early research (Phase 1)Ended earlyNCT00515788What this trial is testingDepoCyt Plus Temozolomide in Patients With Neoplastic MeningitisWho this might be right forNeoplastic Meningitis M.D. Anderson Cancer Center 11
Post-approval studies (Phase 4)Study completedNCT00029523What this trial is testingDepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid TumorWho this might be right forMeningeal Neoplasms Pacira Pharmaceuticals, Inc 100
Testing effectiveness (Phase 2)UnknownNCT05813522What this trial is testingFurmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLCWho this might be right forNon Small Cell Lung Cancer First Affiliated Hospital of Zhejiang University 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07833657What this trial is testingCombined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal MetastasesWho this might be right forLeptomeningeal MetastasesSolid Tumors Jiuda Zhao 28
Not applicableStudy completedNCT07386886What this trial is testingDevelopment of a Novel Graded Prognostic Assessment (BC-LGPA) Model for Breast Cancer Leptomeningeal MetastasisWho this might be right forLeptomeningeal Metastasis in Breast Cancer Jian Zhang,MD 403
Not applicableNot Yet RecruitingNCT07659652What this trial is testingQuality of Life for Patients With Breast Cancer Brain Metastases and Leptomeningeal DiseaseWho this might be right forBreast Cancer, Quality of LifeBreast Cancer, MetastaticBreast Cancer, Metastatic Breast Cancer+2 more University of California, San Francisco 200
Testing effectiveness (Phase 2)Study completedNCT02654106What this trial is testingStereotactic Radiotherapy Plus Temozolomide for Refractory Brain MetastasesWho this might be right forBrain Metastases Chinese Academy of Medical Sciences 65
Testing effectiveness (Phase 2)Looking for participantsNCT06809517What this trial is testingIntrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal MetastasisWho this might be right forLeptomeningeal MetastasisIntrathecal Drug Delivery Guangzhou Medical University 34
Not applicableEnded earlyNCT05414123What this trial is testingA Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSideWho this might be right forLeptomeningeal MetastasisLeptomeningeal DiseaseLeptomeningeal Neoplasms+2 more Biocept, Inc. 40
Early research (Phase 1)Ended earlyNCT00089245What this trial is testingRadiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal CancerWho this might be right forBrain and Central Nervous System TumorsNeuroblastomaSarcoma Y-mAbs Therapeutics 177
Not applicableUnknownNCT06410040What this trial is testingA Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal MetastasisWho this might be right forALK-positive Non-small Cell Lung CancerBrain MetastasesMeningeal Metastasis Sichuan Cancer Hospital and Research Institute 28
Testing effectiveness (Phase 2)Looking for participantsNCT06440954What this trial is testingEfficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal MetastasesWho this might be right forNon-Small Cell Lung Cancer Hunan Province Tumor Hospital 220
Early research (Phase 1)Not Yet RecruitingNCT07674693What this trial is testingPhase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal MetastasesWho this might be right forLeptomeningeal Metastases NYU Langone Health 29
Post-approval studies (Phase 4)UnknownNCT04356222What this trial is testingEfficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal MetastasisWho this might be right forLeptomeningeal MetastasisDurvalumab Hui Bu 30