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Results for “Metastatic or Locally Advanced Malignancies”

2,647 trials

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Showing 20 of 2,647 results

Early research (Phase 1)Looking for participantsNCT07080242
What this trial is testing

Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors

Who this might be right for
Small Cell Lung Cancer Metastatic or Locally AdvancedNeuroendocrine CancerMetastatic or Locally Advanced Neuroendocrine Prostate Cancer+5 more
SystImmune Inc. 120
Testing effectiveness (Phase 2)Active Not RecruitingNCT04171622
What this trial is testing

Lenvatinib and Pembrolizumab for the Treatment of Stage IVB Locally Advanced and Unresectable or Stage IVC Metastatic Anaplastic Thyroid Cancer

Who this might be right for
Metastatic Thyroid Gland CarcinomaPoorly Differentiated Thyroid Gland CarcinomaStage IVB Thyroid Gland Anaplastic Carcinoma AJCC v8+3 more
M.D. Anderson Cancer Center 25
Large-scale testing (Phase 3)Study completedNCT00190762
What this trial is testing

A Study Comparing Pemetrexed Plus Best Supportive Care Versus Best Supportive Care Alone in the Treatment of Mesothelioma

Who this might be right for
Mesothelioma
Eli Lilly and Company 240
Testing effectiveness (Phase 2)Looking for participantsNCT07244705
What this trial is testing

ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC

Who this might be right for
Colorectal Cancer (Diagnosis)Colorectal Cancer MetastaticColorectal Cancer (CRC)+1 more
Anbogen Therapeutics, Inc. 66
Testing effectiveness (Phase 2)Looking for participantsNCT05101070
What this trial is testing

S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors

Who this might be right for
Solid Tumors
Shionogi 282
Early research (Phase 1)Study completedNCT00217373
What this trial is testing

Vaccine Therapy, GM-CSF, and Interferon Alfa-2b in Treating Patients With Locally Advanced or Metastatic Cancer That Expresses Carcinoembryonic Antigen (CEA)

Who this might be right for
Adult Solid Neoplasm
National Cancer Institute (NCI) 33
Testing effectiveness (Phase 2)Ended earlyNCT01272141
What this trial is testing

Lapatinib in Combination With Everolimus in Patients With Advanced, Triple Negative Breast Cancer

Who this might be right for
Breast NeoplasmsBreast CancerCancer of the Breast
Emory University 5
Testing effectiveness (Phase 2)Study completedNCT02448420
What this trial is testing

Study of Palbociclib and Trastuzumab With Endocrine Therapy in HER2-positive Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
SOLTI Breast Cancer Research Group 73
Testing effectiveness (Phase 2)Study completedNCT01561456
What this trial is testing

Study of AXL1717 Compared to Docetaxel to Treat Squamous Cell Carcinoma or Adenocarcinoma of the Lung

Who this might be right for
Non-small-cell Lung CancerSquamous Cell CarcinomaAdenocarcinoma of the Lung
Axelar AB 100
Large-scale testing (Phase 3)UnknownNCT02404051
What this trial is testing

Fulvestrant and EVerolimus Plus EXemestane in Metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerBreast CancerHormone Receptor Positive Tumor+2 more
Consorzio Oncotech 745
Early research (Phase 1)WithdrawnNCT05039931
What this trial is testing

GNC-035, a Tetra-specific Antibody, in Participants With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Breast CancerSolid Tumor
Sichuan Baili Pharmaceutical Co., Ltd.
Testing effectiveness (Phase 2)Study completedNCT01514188
What this trial is testing

Preliminary Efficacy and Safety of INNO-206 Compared to Doxorubicin in Advanced Soft Tissue Sarcoma

Who this might be right for
Metastatic Soft Tissue SarcomaLocally Advanced Soft Tissue SarcomaUnresectable Soft Tissue Sarcoma
ImmunityBio, Inc. 126
Testing effectiveness (Phase 2)Not Yet RecruitingNCT04910386
What this trial is testing

Multicenter Phase 2 Study of Envafolimab in Biliary Tract Cancers

Who this might be right for
Biliary Tract Neoplasms
3D Medicines (Sichuan) Co., Ltd. 126
Early research (Phase 1)Study completedNCT01986166
What this trial is testing

MEHD7945A and Cobimetinib in Patients With Locally Advanced or Metastatic Cancers With Mutant KRAS

Who this might be right for
Neoplasms
Genentech, Inc. 23
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06308939
What this trial is testing

Eribulin Combined With Sintilimab as First-line Treatment for Unresectable Locally Advanced or Metastatic HER2-negative Breast Cancer:A Multicenter, Single-arm,Phase II Clinical Trial

Who this might be right for
Metastatic Breast Cancer
Zhejiang Cancer Hospital 81
Testing effectiveness (Phase 2)Ended earlyNCT00470249
What this trial is testing

Carboplatin and Gemcitabine in Treating Patients With Locally Advanced or Metastatic Breast Cancer

Who this might be right for
Breast Cancer
University of Southampton 5
Testing effectiveness (Phase 2)Looking for participantsNCT07038343
What this trial is testing

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

Who this might be right for
Solid Tumor CancerLocally AdvancedMetastatic Solid Tumors+2 more
Avenzo Therapeutics, Inc. 430
Testing effectiveness (Phase 2)Looking for participantsNCT05716516
What this trial is testing

STUDY02001740;22SCH740: Estradiol For ER+ Advanced Breast Cancer (ESTHER)

Who this might be right for
Metastatic Breast Cancer
Dartmouth-Hitchcock Medical Center 36
Not applicableStudy completedNCT02730104
What this trial is testing

Community-based Neuroendocrine Tumor (NET) Research Study

Who this might be right for
Gastroenteropancreatic Neuroendocrine Tumors
Ipsen 100
Testing effectiveness (Phase 2)Looking for participantsNCT03521830
What this trial is testing

Nivolumab Alone or Plus Relatlimab or Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma

Who this might be right for
Basal Cell Carcinoma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 57
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