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Results for “Microsatellite High Cancers”

118 trials

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Showing 20 of 118 results

Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Not applicableUnknownNCT04640103
What this trial is testing

An Observational Study of Perioperative Immunotherapy in MSI-H Gastrointestinal Tumors

Who this might be right for
To Evaluate the Safety and Effectiveness of Immunotherapy During the Perioperative Treatment Stage in MSI-H Gastrointestinal Cancer
Shen Lin 100
Testing effectiveness (Phase 2)UnknownNCT04521075
What this trial is testing

A Phase Ib Trial to Evaluate the Safety and Efficacy of FMT and Nivolumab in Subjects With Metastatic or Inoperable Melanoma, MSI-H, dMMR or NSCLC

Who this might be right for
Melanoma Stage IVUnresectable MelanomaNSCLC Stage IV
Ella Therapeutics Ltd 42
Not applicableNot Yet RecruitingNCT07689812
What this trial is testing

Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors.

Who this might be right for
NSCLC (Advanced Non-small Cell Lung Cancer)NSCLC (Non-small Cell Lung Cancer)NSCLC (Non-small Cell Lung Carcinoma)+12 more
Natera, Inc. 920
Testing effectiveness (Phase 2)Looking for participantsNCT07262619
What this trial is testing

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Who this might be right for
Advanced Solid TumorsMSI-H or dMMR Advanced Solid TumorsMSI-H/dMMR Gastric Cancer+4 more
Eikon Therapeutics 160
Not applicableStudy completedNCT04482608
What this trial is testing

The mCRC Patients With pMMR/MSS or dMMR/MSI-H Status Received Palliative Chemotherapy Efficacy and Survival

Who this might be right for
Colorectal Cancer MetastaticMismatch Repair DeficiencyMicrosatellite Instability High
Sun Yat-sen University 671
Early research (Phase 1)Looking for participantsNCT07208136
What this trial is testing

JMKX005425 in Patients With MSI-H/dMMR Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Jemincare 102
Testing effectiveness (Phase 2)Active Not RecruitingNCT03767348
What this trial is testing

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)

Who this might be right for
Non-Small Cell Lung Cancer (NSCLC)Microsatellite Instability-High (MSI-H)Non-melanoma Skin Cancer (NMSC)+1 more
Replimune, Inc. 340
Testing effectiveness (Phase 2)Ended earlyNCT05572684
What this trial is testing

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants With Advanced Unresectable or Metastatic Solid Tumors

Who this might be right for
Advanced or Metastatic Solid TumorsMicrosatellite Instability LowMicrosatellite Instability High+9 more
NextCure, Inc. 97
Not applicableStudy completedNCT05162248
What this trial is testing

Microsatellite Instability in Colorectal Cancers

Who this might be right for
Colorectal CancerColorectal CarcinomaMicrosatellite Instability High+2 more
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey 231
Early research (Phase 1)Ended earlyNCT04116320
What this trial is testing

Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors

Who this might be right for
MelanomaBreast CancerMerkel Cell Carcinoma+10 more
Craig L Slingluff, Jr 5
Early research (Phase 1)Study completedNCT02791334
What this trial is testing

Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors

Who this might be right for
Solid TumorMicrosatellite Instability-High (MSI-H) Solid TumorsCutaneous Melanoma+2 more
Eli Lilly and Company 164
Large-scale testing (Phase 3)Active Not RecruitingNCT04008030
What this trial is testing

Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)

Who this might be right for
Metastatic Colorectal Cancer
Bristol-Myers Squibb 839
Testing effectiveness (Phase 2)UnknownNCT04695470
What this trial is testing

Phase II Trial of Fruquintinib With Sintilimab in Treating Selected Refractory Metastatic Colorectal Cancer Patients

Who this might be right for
Colorectal Cancer
Aiping Zhou 70
Large-scale testing (Phase 3)Study completedNCT02563002
What this trial is testing

Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177)

Who this might be right for
Colorectal Carcinoma
Merck Sharp & Dohme LLC 307
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06873854
What this trial is testing

LM-108 in Combination With Toripalimab in Subjects With Advanced Solid Tumours

Who this might be right for
Advanced Solid Tumor
LaNova Medicines Limited 84
Large-scale testing (Phase 3)Active Not RecruitingNCT05239741
What this trial is testing

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)

Who this might be right for
Colorectal Neoplasms
Merck Sharp & Dohme LLC 100
Large-scale testing (Phase 3)Looking for participantsNCT05770102
What this trial is testing

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition

Who this might be right for
MalignancyMalignant NeoplasmLymphoproliferative Disorders+7 more
Cancer Research UK 30
Testing effectiveness (Phase 2)Study completedNCT03241745
What this trial is testing

Nivolumab in Selected Uterine Cancer Patients

Who this might be right for
Uterine CancerEndometrial CarcinomaCarcinosarcoma+4 more
Memorial Sloan Kettering Cancer Center 35
Testing effectiveness (Phase 2)Looking for participantsNCT07244705
What this trial is testing

ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC

Who this might be right for
Colorectal Cancer (Diagnosis)Colorectal Cancer MetastaticColorectal Cancer (CRC)+1 more
Anbogen Therapeutics, Inc. 66
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