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Results for “Microsatellite High Cancers”

109 trials

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Showing 20 of 109 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT07266025
What this trial is testing

Adebrelimab Combined With Induction Chemotherapy or SHR-8068 for Mismatch Repair-Deficient/Microsatellite Instability-High (dMMR/MSI-H) Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma：A Randomized, Non-comparative Phase 2 Study

Who this might be right for
Gastric AdenocarcinomaGastroesophageal AdenocarcinomaMismatch Repair Deficient or MSI-High Solid Tumors+1 more
Shanghai Zhongshan Hospital 30
Testing effectiveness (Phase 2)Looking for participantsNCT07213609
What this trial is testing

Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

Who this might be right for
Neoplasms, ColorectalNeoplasms
GlaxoSmithKline 47
Testing effectiveness (Phase 2)Active Not RecruitingNCT03104439
What this trial is testing

Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer

Who this might be right for
Microsatellite Stable Colorectal CancerPancreatic CancerMSI High Colorectal Cancer
Massachusetts General Hospital 84
Testing effectiveness (Phase 2)WithdrawnNCT06331598
What this trial is testing

Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors with Resectable Disease with Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H)

Who this might be right for
Solid Tumors
Hoffmann-La Roche
Early research (Phase 1)Active Not RecruitingNCT05544929
What this trial is testing

Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

Who this might be right for
Carcinoma, Non-Small-Cell LungCutaneous MelanomaCarcinoma, Renal Cell+9 more
Novartis Pharmaceuticals 126
Testing effectiveness (Phase 2)Active Not RecruitingNCT04715633
What this trial is testing

PD-1 Inhibitors Combined With VEGF Inhibitors for Locally Advanced dMMR/MSI-H Colorectal Cancer

Who this might be right for
Colorectal CancerMicrosatellite Instability High
Sun Yat-sen University 53
Testing effectiveness (Phase 2)Active Not RecruitingNCT04817826
What this trial is testing

TremelImumab aNd Durvalumab For the Non-operatIve Management (NOM) of MSI-high Resectable GC/GEJC.

Who this might be right for
Gastric CancerMicrosatellite Instability
Gruppo Oncologico del Nord-Ovest 31
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06873854
What this trial is testing

LM-108 in Combination With Toripalimab in Subjects With Advanced Solid Tumours

Who this might be right for
Advanced Solid Tumor
LaNova Medicines Limited 84
Early research (Phase 1)Not Yet RecruitingNCT07403721
What this trial is testing

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

Who this might be right for
Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)
Amgen 464
Testing effectiveness (Phase 2)Looking for participantsNCT04114136
What this trial is testing

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Who this might be right for
MelanomaNSCLCHepatocellular Carcinoma+5 more
Dan Zandberg 72
Testing effectiveness (Phase 2)Ended earlyNCT04258111
What this trial is testing

IBI310 in Combination with Sintilimab in Patients with DNA Mismatch Repair Deficient (dMMR)/microsatellite Instability High (MSI-H) Locally-advanced or Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Innovent Biologics (Suzhou) Co. Ltd. 4
Testing effectiveness (Phase 2)Active Not RecruitingNCT04895722
What this trial is testing

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)

Who this might be right for
Colorectal Cancer
Merck Sharp & Dohme LLC 302
Early research (Phase 1)Active Not RecruitingNCT03236935
What this trial is testing

Phase Ib of L-NMMA and Pembrolizumab

Who this might be right for
Non-Small Cell Lung CancerMalignant MelanomaHead and Neck Squamous Cell Carcinoma+3 more
The Methodist Hospital Research Institute 12
Large-scale testing (Phase 3)Looking for participantsNCT06520683
What this trial is testing

Adjuvant PD-1 Blockade for High-risk Stage-II DMMR/MSI-H Colorectal Cancer

Who this might be right for
Colorectal CancerMicrosatellite Instability High
Sun Yat-sen University 180
Very early researchEnded earlyNCT03454243
What this trial is testing

Oral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Advanced or Metastatic Solid Tumors
Hoffmann-La Roche 1
Large-scale testing (Phase 3)Not Yet RecruitingNCT07132008
What this trial is testing

Neoadjuvant CAPOX Plus Tislelizumab vs CAPOX in MSS High-Risk Locally Advanced Colon Cancer

Who this might be right for
Colonic NeoplasmsNeoadjuvant TherapyImmune Checkpoint Inhibitors
First Affiliated Hospital of Guangxi Medical University 94
Testing effectiveness (Phase 2)Looking for participantsNCT06002789
What this trial is testing

Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC

Who this might be right for
Multiple CancerColorectal Cancer
Sixth Affiliated Hospital, Sun Yat-sen University 17
Testing effectiveness (Phase 2)WithdrawnNCT04145193
What this trial is testing

Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC

Who this might be right for
Microsatellite-stable Colorectal Cancer
MedImmune LLC
Testing effectiveness (Phase 2)Looking for participantsNCT05200559
What this trial is testing

T-regulatory Cell Depletion with E7777 Combined with Pembrolizumab in Recurrent or Metastatic Solid Tumors

Who this might be right for
Epithelial Ovarian Cancer
Alexander B Olawaiye, MD 70
Early research (Phase 1)Study completedNCT02635672
What this trial is testing

Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer

Who this might be right for
Neoplasms
Vincerx Pharma, Inc. 110
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