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Results for “Microsatellite-instability (MSI) High Colorectal Cancer (CRC)”

53 trials

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Showing 20 of 53 results

Testing effectiveness (Phase 2)Looking for participantsNCT06698757
What this trial is testing

Different Cycles of Preoperative Neoadjuvant Sintilimab in Mismatch-repair Deficient/microsatellite Instability-high, Locally Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer
Yugui Lian 96
Testing effectiveness (Phase 2)Active Not RecruitingNCT04715633
What this trial is testing

PD-1 Inhibitors Combined With VEGF Inhibitors for Locally Advanced dMMR/MSI-H Colorectal Cancer

Who this might be right for
Colorectal CancerMicrosatellite Instability High
Sun Yat-sen University 53
Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Early research (Phase 1)Ended earlyNCT05909995
What this trial is testing

Interventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid Tumors

Who this might be right for
MelanomaHepatocellular Carcinoma (HCC)Renal Cell Carcinoma (RCC)+3 more
Incyte Corporation 8
Early research (Phase 1)Study completedNCT03538028
What this trial is testing

A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies

Who this might be right for
Cervical CancerMicrosatellite Instability (MSI)-High Endometrial CancerGastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ])+14 more
Incyte Biosciences International Sàrl 22
Testing effectiveness (Phase 2)Active Not RecruitingNCT03228667
What this trial is testing

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

Who this might be right for
Non-Small Cell Lung CancerSmall Cell Lung CancerUrothelial Carcinoma+10 more
ImmunityBio, Inc. 40
Testing effectiveness (Phase 2)Study completedNCT03436563
What this trial is testing

M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

Who this might be right for
Colon AdenocarcinomaHigh-Frequency Microsatellite InstabilityMetastatic Malignant Solid Neoplasm+8 more
M.D. Anderson Cancer Center 4
Large-scale testing (Phase 3)Looking for participantsNCT05239741
What this trial is testing

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)

Who this might be right for
Colorectal Neoplasms
Merck Sharp & Dohme LLC 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT03104439
What this trial is testing

Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer

Who this might be right for
Microsatellite Stable Colorectal CancerPancreatic CancerMSI High Colorectal Cancer
Massachusetts General Hospital 84
Testing effectiveness (Phase 2)Active Not RecruitingNCT06710847
What this trial is testing

Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

Who this might be right for
Neoplasms, ColorectalSolid TumorColon Cancer+2 more
GlaxoSmithKline 14
Not applicableStudy completedNCT03495674
What this trial is testing

Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome

Who this might be right for
High-Frequency Microsatellite InstabilityMismatch Repair Gene MutationMutation-Negative Lynch Syndrome+1 more
M.D. Anderson Cancer Center 21
Large-scale testing (Phase 3)Study completedNCT02563002
What this trial is testing

Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177)

Who this might be right for
Colorectal Carcinoma
Merck Sharp & Dohme LLC 307
Testing effectiveness (Phase 2)Study completedNCT02060188
What this trial is testing

Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread

Who this might be right for
Microsatellite Unstable Colorectal CancerMicrosatellite Stable Colorectal CancerMismatch Repair Proficient Colorectal Cancer+1 more
Bristol-Myers Squibb 385
Testing effectiveness (Phase 2)UnknownNCT04695470
What this trial is testing

Phase II Trial of Fruquintinib With Sintilimab in Treating Selected Refractory Metastatic Colorectal Cancer Patients

Who this might be right for
Colorectal Cancer
Aiping Zhou 70
Testing effectiveness (Phase 2)Study completedNCT02460198
What this trial is testing

Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Previously-Treated Locally Advanced Unresectable or Metastatic Colorectal Cancer (MK-3475-164/KEYNOTE-164)

Who this might be right for
Colorectal Carcinoma
Merck Sharp & Dohme LLC 124
Testing effectiveness (Phase 2)Looking for participantsNCT05919264
What this trial is testing

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Who this might be right for
CancerColorectal CancerSolid Tumor+12 more
Parabilis Medicines, Inc. 595
Testing effectiveness (Phase 2)Looking for participantsNCT03667170
What this trial is testing

KN035 for dMMR/MSI-H Advanced Solid Tumors

Who this might be right for
Solid Tumor
3D Medicines (Sichuan) Co., Ltd. 200
Large-scale testing (Phase 3)Looking for participantsNCT05236972
What this trial is testing

PACE: PD-1 Antibody For dMMR/MSI-H Stage III Colorectal Cancer

Who this might be right for
Colorectal Carcinoma
Sun Yat-sen University 323
Testing effectiveness (Phase 2)Ended earlyNCT04258111
What this trial is testing

IBI310 in Combination with Sintilimab in Patients with DNA Mismatch Repair Deficient (dMMR)/microsatellite Instability High (MSI-H) Locally-advanced or Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Innovent Biologics (Suzhou) Co. Ltd. 4
Testing effectiveness (Phase 2)UnknownNCT04118933
What this trial is testing

PD-1 Antibody JS001 in MSI-H Advanced or Recurrent Colorectal Cancer

Who this might be right for
Colorectal Cancer
Xu jianmin 40
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