Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Midline Diffuse Glioma”

65 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 65 results

Early research (Phase 1)Study completedNCT04264143
What this trial is testing

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Pontine and Thalamic GliomasDiffuse Midline Glioma
Luca Szalontay 9
Early research (Phase 1)Looking for participantsNCT06305910
What this trial is testing

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Who this might be right for
Diffuse Midline Glioma, H3 K27M-MutantRecurrent High Grade Glioma
OX2 Therapeutics 24
Not applicableNot Yet RecruitingNCT07020052
What this trial is testing

Phase II Exploratory Study of Sequential Triple Therapy (Temozolomide/Anlotinib/Bemarituzumab) in Combination With Concurrent Radiotherapy With Temozolomide and Anlotinib for the Maintenance Treatment of Diffuse Midline Gliomas in Children

Who this might be right for
Maintenance Treatment of Diffuse Midline Gliomas in Children
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 33
Early research (Phase 1)Looking for participantsNCT06860594
What this trial is testing

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

Who this might be right for
Astrocytoma, IDH-Mutant, Grade 2Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-MutantRecurrent Adult Diffuse Midline Glioma, H3 K27-Mutant+4 more
National Cancer Institute (NCI) 30
Early research (Phase 1)Ended earlyNCT04771897
What this trial is testing

BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG)

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Bexion Pharmaceuticals, Inc. 10
Early research (Phase 1)Looking for participantsNCT06894979
What this trial is testing

Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma

Who this might be right for
Childhood AstrocytomaChildhood Diffuse Intrinsic Pontine GliomaChildhood Diffuse Midline Glioma+2 more
Children's Oncology Group 54
Early research (Phase 1)Active Not RecruitingNCT04808245
What this trial is testing

Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas

Who this might be right for
Newly Diagnosed H3-mutated Glioma
German Cancer Research Center 15
Large-scale testing (Phase 3)UnknownNCT03243461
What this trial is testing

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)

Who this might be right for
Glioblastoma WHO Grade IVDiffuse Midline Glioma Histone 3 K27M WHO Grade IVAnaplastic Astrocytoma WHO Grade III+2 more
University of Göttingen 167
Not applicableLooking for participantsNCT03101813
What this trial is testing

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-MutantDiffuse Midline Glioma
Children's Hospital Medical Center, Cincinnati 1,500
Testing effectiveness (Phase 2)Looking for participantsNCT04870944
What this trial is testing

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Who this might be right for
Diffuse Midline Glioma, H3 K27-AlteredMetastatic Malignant Neoplasm in the Central Nervous SystemRecurrent Diffuse Intrinsic Pontine Glioma+7 more
Children's Oncology Group 63
Early research (Phase 1)Looking for participantsNCT05835687
What this trial is testing

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

Who this might be right for
Central Nervous System NeoplasmsAtypical Teratoid/Rhabdoid TumorDiffuse Midline Glioma, H3 K27M-Mutant+4 more
St. Jude Children's Research Hospital 48
Early research (Phase 1)Study completedNCT01922076
What this trial is testing

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Who this might be right for
Anaplastic AstrocytomaAnaplastic OligoastrocytomaDiffuse Intrinsic Pontine Glioma+3 more
National Cancer Institute (NCI) 46
Early research (Phase 1)Looking for participantsNCT05762419
What this trial is testing

FUS Etoposide for DMG

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Columbia University 10
Early research (Phase 1)Looking for participantsNCT04943848
What this trial is testing

RHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3 K27M-Mutant
Ann & Robert H Lurie Children's Hospital of Chicago 36
Not applicableLooking for participantsNCT05839379
What this trial is testing

Targeted Pediatric High-Grade Glioma Therapy

Who this might be right for
High Grade GliomaDiffuse Intrinsic Pontine GliomaAnaplastic Astrocytoma+6 more
Nationwide Children's Hospital 350
Early research (Phase 1)Looking for participantsNCT05544526
What this trial is testing

CAR T Cells to Target GD2 for DMG

Who this might be right for
Diffuse Midline Glioma, H3 K27M-Mutant
University College, London 12
Very early researchWithdrawnNCT04051047
What this trial is testing

Gemcitabine in Newly-Diagnosed Diffuse Midline Glioma

Who this might be right for
Glial Tumor of BrainDiffuse Intrinsic Pontine GliomaGlioma
University of Michigan Rogel Cancer Center
Not applicableLooking for participantsNCT06140719
What this trial is testing

XPedite: A Study to Expedite DIPG and DMG Research

Who this might be right for
OncologyDIPGDMG
xCures 400
Testing effectiveness (Phase 2)Study completedNCT02960230
What this trial is testing

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

Who this might be right for
Diffuse Intrinsic Pontine GliomaGliomaDiffuse Midline Glioma, H3 K27M-Mutant
Sabine Mueller, MD, PhD 50
Testing effectiveness (Phase 2)Temporarily pausedNCT05123534
What this trial is testing

Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG

Who this might be right for
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma
SonALAsense, Inc. 15
Load More Results