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Results for “Mismatch Repair Proficient Colorectal Cancer”

35 trials

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Showing 20 of 35 results

Large-scale testing (Phase 3)Not Yet RecruitingNCT06832917
What this trial is testing

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

Who this might be right for
Rectal Cancer
Wan He 238
Testing effectiveness (Phase 2)Looking for participantsNCT06792695
What this trial is testing

Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
AstraZeneca 120
Testing effectiveness (Phase 2)Active Not RecruitingNCT03851614
What this trial is testing

Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors

Who this might be right for
Mismatch Repair Proficient Colorectal CancerPancreatic AdenocarcinomaLeiomyosarcoma
University Health Network, Toronto 90
Early research (Phase 1)Ended earlyNCT04108481
What this trial is testing

Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticColon CancerMetastatic Colorectal Cancer+7 more
University of Iowa 5
Testing effectiveness (Phase 2)Looking for participantsNCT06356597
What this trial is testing

Tislelizumab With Fruquintinib, Metronidazole, in Mismatch Repair-proficient or Microsatellite Stability, Advanced Colorectal Cancer: a Multicenter, Single Arm, Clinical Trial

Who this might be right for
Colorectal Cancer
Jing-yuan Fang, MD, Ph. D 25
Testing effectiveness (Phase 2)WithdrawnNCT05582031
What this trial is testing

Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers

Who this might be right for
Anal Squamous Cell CarcinomaColorectal NeoplasmsSoft Tissue Sarcoma+5 more
Translational Research in Oncology
Testing effectiveness (Phase 2)Looking for participantsNCT07079631
What this trial is testing

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
BioNTech SE 482
Testing effectiveness (Phase 2)Looking for participantsNCT05870800
What this trial is testing

Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER

Who this might be right for
Stage I Colon CancerStage II Colon CancerStage III Colon Cancer
Baylor College of Medicine 28
Testing effectiveness (Phase 2)WithdrawnNCT04119830
What this trial is testing

Rintatolimod and Pembrolizumab for the Treatment of Refractory Metastatic or Unresectable Colorectal Cancer

Who this might be right for
Metastatic Colorectal AdenocarcinomaMicrosatellite StableMismatch Repair Proficient+10 more
Roswell Park Cancer Institute
Testing effectiveness (Phase 2)UnknownNCT03519412
What this trial is testing

Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status

Who this might be right for
Colorectal NeoplasmsMicrosatellite Instability
IFOM ETS - The AIRC Institute of Molecular Oncology 102
Testing effectiveness (Phase 2)Study completedNCT04126733
What this trial is testing

Study on the Effectiveness and Safety of the Combination of the Two Drugs Regorafenib and Nivolumab in Patients With Colorectal Cancer (Cancer of the Colon or Rectum Classified as Proficient Mismatch Repair and Microsatellite Stable)

Who this might be right for
Colorectal Cancer
Bayer 70
Testing effectiveness (Phase 2)Study completedNCT02437136
What this trial is testing

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)

Who this might be right for
Non-Small Cell Lung CancerMelanomaMismatch Repair-Proficient Colorectal Cancer
Syndax Pharmaceuticals 191
Testing effectiveness (Phase 2)Looking for participantsNCT07244705
What this trial is testing

ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC

Who this might be right for
Colorectal Cancer (Diagnosis)Colorectal Cancer MetastaticColorectal Cancer (CRC)+1 more
Anbogen Therapeutics, Inc. 66
Testing effectiveness (Phase 2)Looking for participantsNCT06522919
What this trial is testing

Sequential Immunochemotherapy Treatment with Pembrolizumab Plus Dendritic Cell (DC) Vaccine Followed by Trifluridine/Tipiracil Plus Bevacizumab in Refractory Mismatch-repair-proficient (pMMR) or Microsatellite-stable (MSS) Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer MetastaticMicrosatellite Stable Colorectal CarcinomaRefractory Mismatch-repair-proficient (pMMR) Metastatic Colorectal Cancer
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Early research (Phase 1)Study completedNCT03712943
What this trial is testing

Regorafenib and Nivolumab in Mismatch Repair (MMR) Refractory Colorectal Cancer

Who this might be right for
Colorectal CancerMetastatic Colorectal CancerColon Cancer
H. Lee Moffitt Cancer Center and Research Institute 52
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07359456
What this trial is testing

Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases

Who this might be right for
Metastatic Colorectal Cancer
UNICANCER 130
Testing effectiveness (Phase 2)UnknownNCT05160727
What this trial is testing

Radiotherapy Combined With Tislelizumab and Irinotecan in MSS/pMMR Recurrence and Metastatic Colorectal Cancer

Who this might be right for
Mismatch Repair-proficientColorectal Cancer MetastaticMicrosatellite Stable
Zhejiang Cancer Hospital 44
Testing effectiveness (Phase 2)Looking for participantsNCT06856837
What this trial is testing

- IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases

Who this might be right for
Metastatic Colorectal Cancer
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest 140
Testing effectiveness (Phase 2)Study completedNCT02981524
What this trial is testing

Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 17
Testing effectiveness (Phase 2)Active Not RecruitingNCT05609370
What this trial is testing

A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer

Who this might be right for
Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer
BeiGene 113
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