Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Mismatch Repair-Proficient”

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 0 results

Not applicableStudy completedNCT04482608
What this trial is testing

The mCRC Patients With pMMR/MSS or dMMR/MSI-H Status Received Palliative Chemotherapy Efficacy and Survival

Who this might be right for
Colorectal Cancer MetastaticMismatch Repair DeficiencyMicrosatellite Instability High
Sun Yat-sen University 671
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07175636
What this trial is testing

QL1706 With Short-Course Radiotherapy and Chemotherapy for MSS Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)Mismatch Repair-Proficient (pMMR) Rectal CancerNon-metastatic Rectal Cancer
Sun Yat-sen University 66
Testing effectiveness (Phase 2)Active Not RecruitingNCT05609370
What this trial is testing

A Study Investigating the Efficacy and Safety of Alcestobart (LBL-007) Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer

Who this might be right for
Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer
BeiGene 113
Testing effectiveness (Phase 2)Study completedNCT03152565
What this trial is testing

Avelumab Plus Autologous Dendritic Cell Vaccine in Pre-treated Metastatic Colorectal Cancer Patients

Who this might be right for
Colorectal Carcinoma
Grupo Espanol Multidisciplinario del Cancer Digestivo 28
Early research (Phase 1)Looking for participantsNCT05603910
What this trial is testing

Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation Therapy for pMMR Recurrent/Unresectable Endometrial Carcinoma

Who this might be right for
Recurrent Endometrial CarcinomaUnresectable Endometrial Carcinoma
Aaron Wolfson 18
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07591597
What this trial is testing

A Multicenter, Phase Ib/II Clinical Trial to Evaluate the Efficacy and Safety of Concurrent Combination Therapy of S-531011 Plus Fruquintinib or S-531011 Plus Fruquintinib Plus Pembrolizumab in Patients With MSS/pMMR Colorectal Cancer

Who this might be right for
Metastatic Colorectal NeoplasmsMicrosatellite Stable / Proficient Mismatch Repair Colorectal Cancer
National Cancer Center Hospital East 68
Testing effectiveness (Phase 2)Study completedNCT03711058
What this trial is testing

Study of PI3Kinase Inhibition (Copanlisib) and Anti-PD-1 Antibody Nivolumab in Relapsed/Refractory Solid Tumors With Expansions in Mismatch-repair Proficient (MSS) Colorectal Cancer

Who this might be right for
Unresectable or Metastatic Microsatellite Stable (MSS) Solid TumorMicrosatellite Stable (MSS) Colon Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 48
Large-scale testing (Phase 3)Not Yet RecruitingNCT06832917
What this trial is testing

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

Who this might be right for
Rectal Cancer
Wan He 238
Early research (Phase 1)Ended earlyNCT02991196
What this trial is testing

Antibody DS-8273a Administered in Combination With Nivolumab in Subjects With Advanced Colorectal Cancer

Who this might be right for
Colorectal Neoplasm
Daiichi Sankyo 4
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07621562
What this trial is testing

Tafolecimab Combined With Sintilimab and SOX in the Treatment of pMMR/MSS Gastric Cancer

Who this might be right for
Gastric AdenocarcinomaEsophagogastric Juction CancerProficient Mismatch Repair
First Affiliated Hospital of Zhejiang University 30
Testing effectiveness (Phase 2)Looking for participantsNCT07594015
What this trial is testing

Pembrolizumab and Lenvatinib in Mismatch Repair Proficient Recurrent Endometrial Cancer After Failure of First-Line Therapy With Platinum-based Doublet and Immunotherapy

Who this might be right for
Recurrent Endometrial Cancer
University of Miami 46
Testing effectiveness (Phase 2)Active Not RecruitingNCT05205330
What this trial is testing

Vorbipiprant (CR6086) / Balstilimab (AGEN2034) Combination in Stage IV Refractory pMMR - MSS CRC, and Other Metastatic GI Cancers

Who this might be right for
Refractory Metastatic Colorectal CancerSolid TumorMetastatic Microsatellite-stable Colorectal Cancer+3 more
Rottapharm Biotech 107
Testing effectiveness (Phase 2)Study completedNCT02437136
What this trial is testing

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)

Who this might be right for
Non-Small Cell Lung CancerMelanomaMismatch Repair-Proficient Colorectal Cancer
Syndax Pharmaceuticals 191
Testing effectiveness (Phase 2)Study completedNCT03519412
What this trial is testing

Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status

Who this might be right for
Colorectal NeoplasmsMicrosatellite Instability
IFOM ETS - The AIRC Institute of Molecular Oncology 107
Testing effectiveness (Phase 2)Study completedNCT02834052
What this trial is testing

Pembrolizumab + Poly-ICLC in MRP Colon Cancer

Who this might be right for
Metastatic Colon CancerSolid Tumor
Asha Nayak 42
Testing effectiveness (Phase 2)Looking for participantsNCT07735624
What this trial is testing

RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cancer

Who this might be right for
Early Rectal CancerStage I Rectal CancerMicrosatellite Stable Rectal Carcinoma
Dana-Farber Cancer Institute 16
Testing effectiveness (Phase 2)Active Not RecruitingNCT06356597
What this trial is testing

Tislelizumab With Fruquintinib, Metronidazole, in Mismatch Repair-proficient or Microsatellite Stability, Advanced Colorectal Cancer: a Multicenter, Single Arm, Clinical Trial

Who this might be right for
Colorectal Cancer
Jing-yuan Fang, MD, Ph. D 33
Testing effectiveness (Phase 2)Looking for participantsNCT07244705
What this trial is testing

ABT-301 Plus Tislelizumab With Bevacizumab in pMMR/Non-MSI-H Locally Advanced or mCRC

Who this might be right for
Colorectal Cancer (Diagnosis)Colorectal Cancer MetastaticColorectal Cancer (CRC)+1 more
Anbogen Therapeutics, Inc. 66
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07808151
What this trial is testing

Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer

Who this might be right for
Colon CancerMicrosatellite Stable (MSS) Colon CancerProficient Mismatch Repair (pMMR) Colon Cancer
Solstice Oncology, Inc. 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT04166721
What this trial is testing

WaKING: Wnt and checKpoint INhibition in Gastric Cancer

Who this might be right for
Metastatic Esophageal CancerMetastatic Gastric Cancer
Royal Marsden NHS Foundation Trust 52
Next Page