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Results for “Mismatch Repair-proficient”

57 trials

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Showing 20 of 57 results

Testing effectiveness (Phase 2)UnknownNCT05160727
What this trial is testing

Radiotherapy Combined With Tislelizumab and Irinotecan in MSS/pMMR Recurrence and Metastatic Colorectal Cancer

Who this might be right for
Mismatch Repair-proficientColorectal Cancer MetastaticMicrosatellite Stable
Zhejiang Cancer Hospital 44
Testing effectiveness (Phase 2)Looking for participantsNCT06864013
What this trial is testing

SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
First Affiliated Hospital of Zhejiang University 116
Testing effectiveness (Phase 2)Looking for participantsNCT05872685
What this trial is testing

Perioperative Chemotherapy Combined With Serplulimab or Placebo for pMMR Locally Advanced Gastric Adenocarcinoma (FOCUS-05)

Who this might be right for
Adenocarcinoma of the StomachAdenocarcinoma of Esophagogastric JunctionProficient Mismatch Repair
Yu jiren 314
Testing effectiveness (Phase 2)Looking for participantsNCT06856837
What this trial is testing

- IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases

Who this might be right for
Metastatic Colorectal Cancer
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest 140
Testing effectiveness (Phase 2)Ended earlyNCT05263492
What this trial is testing

Study of Lenvatinib w/ Pembro in Black Participants w/Mismatch Repair-Prof Recurrent Endometrial Cancer

Who this might be right for
Endometrial CancerMismatch Repair-ProficientRecurrent Endometrial Cancer
Virginia Commonwealth University 4
Testing effectiveness (Phase 2)Study completedNCT02981524
What this trial is testing

Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 17
Large-scale testing (Phase 3)Looking for participantsNCT06952504
What this trial is testing

Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Who this might be right for
Endometrial Cancer
Merck Sharp & Dohme LLC 1,123
Testing effectiveness (Phase 2)UnknownNCT04483219
What this trial is testing

Tyrosine Kinase Inhibitor (TKI) + Anti-PD-1 Antibody in TKI-responded Microsatellite Stability/Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Adenocarcinoma.

Who this might be right for
MSSpMMRMetastatic Colorectal Adenocarcinoma
China Medical University, China 53
Large-scale testing (Phase 3)Not Yet RecruitingNCT07578649
What this trial is testing

Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer

Who this might be right for
Endometrial NeoplasmsEndometrial Cancer
Pfizer 600
Testing effectiveness (Phase 2)Study completedNCT03396926
What this trial is testing

Pembrolizumab, Capecitabine, and Bevacizumab for Treating Colorectal Cancer

Who this might be right for
Microsatellite StableMismatch Repair Protein ProficientStage III Colorectal Cancer AJCC v7+5 more
University of California, San Francisco 44
Testing effectiveness (Phase 2)Study completedNCT04126733
What this trial is testing

Study on the Effectiveness and Safety of the Combination of the Two Drugs Regorafenib and Nivolumab in Patients With Colorectal Cancer (Cancer of the Colon or Rectum Classified as Proficient Mismatch Repair and Microsatellite Stable)

Who this might be right for
Colorectal Cancer
Bayer 70
Testing effectiveness (Phase 2)WithdrawnNCT06730100
What this trial is testing

CBX-12 for the Treatment of Metastatic Chemotherapy-Refractory Microsatellite Stable Colorectal Cancer

Who this might be right for
Metastatic Mismatch Repair Proficient Colorectal CarcinomaRefractory Mismatch Repair Proficient Colorectal CarcinomaStage IV Colorectal Cancer AJCC v8
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)WithdrawnNCT04119830
What this trial is testing

Rintatolimod and Pembrolizumab for the Treatment of Refractory Metastatic or Unresectable Colorectal Cancer

Who this might be right for
Metastatic Colorectal AdenocarcinomaMicrosatellite StableMismatch Repair Proficient+10 more
Roswell Park Cancer Institute
Testing effectiveness (Phase 2)Looking for participantsNCT06792695
What this trial is testing

Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
AstraZeneca 80
Testing effectiveness (Phase 2)Looking for participantsNCT05870800
What this trial is testing

Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER

Who this might be right for
Stage I Colon CancerStage II Colon CancerStage III Colon Cancer
Baylor College of Medicine 28
Testing effectiveness (Phase 2)Looking for participantsNCT06366347
What this trial is testing

ALPINE: Maintenance Letrozole/Abemaciclib

Who this might be right for
Endometrial CancerRecurrent Endometrial CancerTP53
Dana-Farber Cancer Institute 32
Testing effectiveness (Phase 2)Study completedNCT02060188
What this trial is testing

Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread

Who this might be right for
Microsatellite Unstable Colorectal CancerMicrosatellite Stable Colorectal CancerMismatch Repair Proficient Colorectal Cancer+1 more
Bristol-Myers Squibb 385
Large-scale testing (Phase 3)Looking for participantsNCT06989112
What this trial is testing

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Who this might be right for
Endometrial Cancer
AstraZeneca 600
Testing effectiveness (Phase 2)Looking for participantsNCT06843434
What this trial is testing

Botensilimab and Balstilimab for Rectal Adenocarcinoma

Who this might be right for
Microsatellite Stable Rectal CarcinomaLocally Advanced Rectal Adenocarcinoma
Memorial Sloan Kettering Cancer Center 40
Testing effectiveness (Phase 2)Looking for participantsNCT07079631
What this trial is testing

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
BioNTech SE 482
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