Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Moderate to Severe Alzheimer's Disease”

36 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 36 results

Post-approval studies (Phase 4)Study completedNCT00800709
What this trial is testing

Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Shanghai Mental Health Center 26
Testing effectiveness (Phase 2)Ended earlyNCT01766336
What this trial is testing

A 36-Week Safety Extension Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
OPKO Health, Inc. 296
Large-scale testing (Phase 3)Study completedNCT00322153
What this trial is testing

The Safety and Efficacy of Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Dementia of the Alzheimer's Type
Forest Laboratories 677
Post-approval studies (Phase 4)WithdrawnNCT00375557
What this trial is testing

Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients

Who this might be right for
Alzheimer's DiseaseDementiaBehavioral Symptoms
University of Cincinnati
Not applicableNot Yet RecruitingNCT06978946
What this trial is testing

Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients

Who this might be right for
Alzheimer DiseaseLewy Body Dementia (LBD)Frontotemporal Dementia (FTD)+2 more
RenJi Hospital 85
Not applicableEnded earlyNCT01001637
What this trial is testing

Efficacy and Safety of Curcumin Formulation in Alzheimer's Disease

Who this might be right for
Alzheimer Disease
Jaslok Hospital and Research Centre 26
Testing effectiveness (Phase 2)Study completedNCT00325728
What this trial is testing

Efficacy and Safety of Ramelteon in Subjects With Mild to Moderate Alzheimer's Disease

Who this might be right for
Chronic Insomnia
Takeda 74
Large-scale testing (Phase 3)Study completedNCT00478205
What this trial is testing

Comparison of 23 mg Donepezil Sustained Release (SR) to 10 mg Donepezil Immediate Release (IR) in Patients With Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Eisai Inc. 1,467
Post-approval studies (Phase 4)Study completedNCT00234637
What this trial is testing

Rivastigmine Monotherapy and Combination Therapy With Memantine in Patients With Moderately Severe Alzheimer's Disease Who Failed to Benefit From Previous Cholinesterase Inhibitor Treatment

Who this might be right for
Alzheimer's Disease
Novartis 204
Large-scale testing (Phase 3)UnknownNCT04229927
What this trial is testing

BPDO-1603 Intervention Trial in Patients With Moderate-to-severe Alzheimer's Disease

Who this might be right for
Moderate-to-severe Alzheimer's Disease
Hyundai Pharmaceutical Co., LTD. 712
Large-scale testing (Phase 3)WithdrawnNCT04187547
What this trial is testing

A Phase III Multi Regional Clinical Trial (MRCT) of Tricaprilin in Mild to Moderately Severe Probable Alzheimer's Disease With Optional Open Label Extension

Who this might be right for
Alzheimer's Disease
Cerecin
Large-scale testing (Phase 3)Ended earlyNCT00912288
What this trial is testing

Efficacy Study Of Dimebon In Patients With Moderate To Severe Alzheimer's Disease

Who this might be right for
Alzheimer Disease
Pfizer 86
Post-approval studies (Phase 4)UnknownNCT00866060
What this trial is testing

Donepezil and Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Moderate to Severe Alzheimer's Disease
King's College London 800
Large-scale testing (Phase 3)Ended earlyNCT00857233
What this trial is testing

Safety and Tolerability of Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
H. Lundbeck A/S 297
Testing effectiveness (Phase 2)Study completedNCT01735630
What this trial is testing

Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
OPKO Health, Inc. 350
Testing effectiveness (Phase 2)Looking for participantsNCT06745583
What this trial is testing

Assess the Safety of EI-1071 and the Effects of EI-1071 on Neuroinflammation in Alzheimer's Disease Patients

Who this might be right for
Mild, Moderate, or Severe Alzheimer's Disease
Elixiron Immunotherapeutics (Hong Kong) Ltd. 15
Post-approval studies (Phase 4)UnknownNCT05430867
What this trial is testing

Efficacy and Safety of Memantine and Sodium Oligomannate in Patients With Moderate to Severe Alzheimer's Disease

Who this might be right for
TreatmentEfficacySafety+1 more
First Affiliated Hospital Xi'an Jiaotong University 150
Large-scale testing (Phase 3)Study completedNCT00566501
What this trial is testing

Open-Label Extension Study of 23 mg Donepezil SR in Participants With Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Eisai Inc. 915
Large-scale testing (Phase 3)Ended earlyNCT00857649
What this trial is testing

Efficacy and Safety of Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
H. Lundbeck A/S 369
Large-scale testing (Phase 3)Study completedNCT00097916
What this trial is testing

An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients With Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Forest Laboratories 34
Load More Results